Skip to main content
Log in

A polymorphic variant of the lactate dehydrogenase B subunit in the rat

  • Published:
Genetica Aims and scope Submit manuscript

Abstract

A new electrophoretic variant of the lactate dehydrogenase B subunit was found in the erythrocytes of the COP strain of the rat. The location of the band after the electrophoresis suggested a product of the structural gene for the B subunit. Two alleles that regulated the high amount (Ldh-2 a)or the low amount (Ldh-2 b)of the B subunit were found and segregated in Mendelian fashion. The activity was regulated by the closely linked (<1 cM) regulatory gene Ldr-1.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Balinsky, D., Platz, C. E. & Lewis, J. W., 1983. Isozyme patterns of normal benign and malignant human breast tissues. Cancer Res. 43: 5895–5901.

    Google Scholar 

  • Bender, K., Adams, M., Baverstock, P. R., denBieman, M., Bissbort, S., Bidicka, R., Buteher, G. W., Cramer, D. V., vonDeimling, O., Festing, M. F. W., Gunther, E., Guttmann, R. D., Hedrich, H. J., Kendall, P. B., Kluge, R., Moutier, R., Simon, B., Womack, J. E., Yamada, J. & vanZutphen, B., 1984. Biochemical markers in inbred strains of the rat (Rattus norvegicus). Biochem. Genet. 19: 257–266.

    Google Scholar 

  • Blatt, J., Spiegel, R. J., Papadopoulos, N. M., Lazarou, S. A., Magrath, I. T. & Poplack, D. G., 1982. Lactate dehydrogenase iso-enzymes in normal and malignant human lymphoid cells. Blood 60: 491–494.

    Google Scholar 

  • Bonhomme, F. & Selander, R. K., 1978. Estimating total genic diversity in the house mouse. Biochem. Genet. 16: 287–298.

    Google Scholar 

  • Bosl, G. J., Geller, N. L., Cirrincione, C., Nisselbaum, J., Vugrin, D., Whitmore, W. F.Jr. & Golbey, R. B., 1983. Serum tumor markers in patients with metastatic germ cell tumors of the testis, a 10 year experience. Am. J. Med. 75: 29–35.

    Google Scholar 

  • Harris, H. & Hopkinson, D. A., 1976. Handbook of enzyme electrophoresis in human genetics. American Elsevier Publishing Company, New York.

    Google Scholar 

  • Markert, C. L., 1963. Lactate dehydrogenase isozymes: Dissociation and recombination of subunits. Science 140: 1329–1330.

    Google Scholar 

  • Paule, B., Francoual, J., Lindenbaum, A., Derrieux, C., Russo, C., Gerbet, D. & Leluc, R., 1984. Lactate dehydrogenase isoenzyme activity in malignant hematological diseases. Biomed. Pharmacother. 38: 62–65.

    Google Scholar 

  • Singh, R. S., Lewontin, R. C. & Felton, A. A., 1976. Genetic heterogeneity within electrophoretic alleles of xanthine dehydrogenase in Drosophila pseudoobscura. Genetics 84: 609–629.

    Google Scholar 

  • Stole, V., 1985. Polymorphism of lactate dehydrogenase B subunit in rat erythrocytes. Genet. Res. 45: 101–106.

    Google Scholar 

  • Stole, V. & Gill, T. J.III, 1983. Linkage and polymorphism of a gene controlling lactate dehydrogenase in the rat. Biochem. Genet. 21: 933–941.

    Google Scholar 

  • Suarez, C. B., Andreeff, M. & Miller, D. R., 1984. Serum lactate dehydrogenase values in childhood acute leukemias and non-Hodgkins lymphoma. Med. Ped. Oncol. 12: 89–92.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Stolc, V. A polymorphic variant of the lactate dehydrogenase B subunit in the rat. Genetica 72, 65–68 (1987). https://doi.org/10.1007/BF00126979

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00126979

Keywords

Navigation