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Helicobacter pylori infection and chronic atrophic gastritis among Japanese blood donors: a cross-sectional study

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To evaluate an association between Helicobacter pylori (H. pylori) infection and chronic atrophic gastritis (CAG), an established precursor of gastric cancer, we performed a cross-sectional study using IgG antibody against H. pylori and pepsinogens of blood donors in four prefectures in Japan. Although a geographic correlation between the age-adjusted prevalence rates for H. pylori infection and those for CAG was not seen, the age-adjusted odds ratios (OR) of H. pylori infection for CAG were high in each area (around five for men and from four to 12.6 for women). The association between them weakened with advancing age; the ORs in the youngest age group (16–29 yrs) and in the oldest age group (50–64 yrs) were 12.5 and 2.8 for men, and 11.5 and 5.2 for women, respectively. These findings suggest that H. pylori infection is strongly associated with CAG, while there are some other factors interacting in the development of CAG. A prospective cohort study in which CAG and H. pylori infection are taken into account will be necessary to assess the risks of gastric cancer.

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Authors and Affiliations

  1. Department of Public Health, Tohoku University School of Medicine, Japan

    Akira Fukao, Shouko Komatsu, Yoshitaka Tsubono & Shigeru Hisamichi

  2. Sendai Municipal Institute of Public Health, Japan

    Hitoshi Ohori & Takeshi Kizawa

  3. Akita Blood Center, Japan

    Noriko Ohsato

  4. Iwate Blood Center, Japan

    Norio Fujino

  5. Miyagi Blood Center, Japan

    Nobuyoshi Endo

  6. Okinawa Blood Center, Japan

    Masaharu Iha

Authors
  1. Akira Fukao
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  2. Shouko Komatsu
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  3. Yoshitaka Tsubono
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  4. Shigeru Hisamichi
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  5. Hitoshi Ohori
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  6. Takeshi Kizawa
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  7. Noriko Ohsato
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  8. Norio Fujino
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  9. Nobuyoshi Endo
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  10. Masaharu Iha
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Additional information

This work was supported in part by a Grant-in-Aid for Cancer Research from The Ministry of Education, Science and Culture of Japan.

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Fukao, A., Komatsu, S., Tsubono, Y. et al. Helicobacter pylori infection and chronic atrophic gastritis among Japanese blood donors: a cross-sectional study. Cancer Causes Control 4, 307–312 (1993). https://doi.org/10.1007/BF00051332

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  • DOI: https://doi.org/10.1007/BF00051332

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