Skip to main content
SpringerLink
Log in

Potential of the scid mouse as a host for human tumors

  • Published:
Cancer and Metastasis Reviews Aims and scope Submit manuscript

Summary

Animal models of human tumors and their metastases that effectively mimic clinical disease are in considerable demand. While it is certainly true that athymic nude mice provide us with useful models to study a large number of human tumors in vivo, it is also well known that nude mice usually do not develop spontaneous metastases and are not suitable for all types of tumors. Therefore, the scid mouse that allows disseminated growths for a number of human tumors, particularly hematologic disorders and malignant melanoma, can be used preferentially for the investigation of such malignancies. The potential to study the interaction of human immune cells and human tumor in an in vivo model is another unique feature of scid mice that will add to their usefulness in experimental cancer research.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bosma GC, Custer RP, Bosma MJ: A severe combined immunodeficiency mutation in the mouse. Nature 301: 527–530, 1983

    Google Scholar 

  2. Schuler M, Weiler IJ, Schuler A, Phillips RA, Rosenberg N, Mak TW, Kearney JF, Perry RP, Bosma MJ: Rearrangement of antigen receptor genes is defective in mice with severe combined immune deficiency. Cell 46: 963–972, 1986

    Google Scholar 

  3. Custer RP, Bosma GC, Bosma MJ: Severe combined immunodeficiency (SCID) in the mouse. Pathology, reconstitution, neoplasms. Am J Pathol 120: 464–477, 1985

    Google Scholar 

  4. Fulop GM, Phillips RA: Full reconstitution of the immune deficiency in scid mice with normal stem cells requires low-dose irradiation of the recipients. J Immunol 136: 4438–4443, 1986

    Google Scholar 

  5. McCune JM, Namikawa R, Kaneshima H, Shultz LD, Lieberman M, Weissman IL: The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function. Science 241: 1632–1639, 1988

    Google Scholar 

  6. Mosier DE, Gulizia RJ, Baird SM, Wilson DB: Transfer of a functional humane immune system to mice with severe combined immunodeficiency. Nature 335: 256–259, 1988

    Google Scholar 

  7. Krowka JF, Sarin S, Namikawa R, McCune JM, Kaneshima H: Human T cells in the scid-hu mouse are phenotypically normal and functionally competent. J Immunol 146: 3751–3756, 1991

    Google Scholar 

  8. Barry TS, Jones DM, Richter CB, Haynes BF: Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: differential engraftment of thymic components with irradiation versus antiasialo GM-1 immunosuppressive regimens. J Exp Med 173: 167–180, 1991

    Google Scholar 

  9. McCune JM, Namikawa H, Shih CC, Rabin L, Kaneshima H: Suppression of HIV-infection in AZT-treated SCID-hu mice. Science 247: 564–566, 1990

    Google Scholar 

  10. Mosier DE, Gulizia RJ, Baird SM, Wilson DB, Spector DH, Spector SA: Human immunodeficiency virus infection of human-PBL-SCID mice. Science 251: 791–794, 1991

    Google Scholar 

  11. Sharkey FE, Fogh J: Considerations in the use of nude mice for cancer research. Cancer Met Rev 3: 341–360, 1984

    Google Scholar 

  12. Fidler IJ: Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis. Cancer Met Rev 5: 29–49, 1986

    Google Scholar 

  13. Cannon MJ, Pisa P, Fox RI, Cooper NR: Epstein-Barr Virus induces aggressive lymphoproliferative disorders of human B cell origin in SCID/hu chimeric mice. J Clin Invest 85: 1333–1337, 1990

    Google Scholar 

  14. Rowe M, Young LS, Crocker J, Stokes H, Henderson S, Rickinson AB: Epstein-Barr Virus (EBV)-associated lymphoproliferative disease in the SCID mouse model: Implications for the pathogenesis of EBV-positive lymphomas in man. J Exp Med 173: 147–158, 1991

    Google Scholar 

  15. Ghetie MA, Richardson J, Tucker T, Jones D, Uhr JW, Vitetta ES: Disseminated or localized growth of a human B-cell tumor (DAUDI) in SCID mice. Int J Cancer 45: 481–485, 1990

    Google Scholar 

  16. Kamel-Reid S, Letarte M, Sirard C, Doedens M, Grunberger T, Fulop G, Freedman MH, Phillips RA, Dick JE: A model of acute lymphoblastic leukemia in immune-deficient SCID mice. Science 246: 1597–1600, 1989

    Google Scholar 

  17. Charley MR, Tharp M, Locker J, Deng JS, Goslen JB, Mauro T, McCoy P, Abell E, Jegasothy B: Establishment of a human cutaneous T-cell lymphoma in C.B-17 SCID mice. J Invest Dermatol 94: 381–384, 1990

    Google Scholar 

  18. Reddy S, Piccione D, Takita H, Bankert RB: Human lung tumor growth established in the lung and subcutaneous tissue of mice with severe combined immunodeficiency. Cancer Res 47: 2456–2460, 1987

    Google Scholar 

  19. Phillips RA, Jewett MAS, Gallie BL: Growth of human tumors in immune deficient scid mice and nude mice. Curr. Topics Microbiol Immunol 152: 259–263, 1989

    Google Scholar 

  20. Nomura T, Takahama Y, Hongyo T, Inohara H, Takatera H, Fukushima H, Ishii Y, Hamaoka T: SCID (severe combined immunodeficiency) mice as a new system to investigate metastasis of human tumors. J Radiat Res 31: 288–292, 1990

    Google Scholar 

  21. Cornil I, Man S, Fernandez B, Kerbel RS: Enhanced tumorigenicity, melanogenesis, and metastases of a human malignant melanoma after subdermal implantation in nude mice. J Natl Cancer Inst 81: 938–944, 1989

    Google Scholar 

  22. Iliopoulos D, Ernst C, Steplewski Z, Jambrosic JA, Rodeck U, Herlyn M, Clark WH, Koprowski H, Herlyn D: Inhibition of metastases of a human melanoma xenograft by monoclonal antibody to the GD2/GD3 gangliosides. J Natl Cancer Inst 81: 440–444, 1989

    Google Scholar 

  23. Welch DR, Bisi JE, Miller BE, Conaway D, Seftor EA, Yohem KH, Gilmore LB, Seftor REB, Nakajima M, Hendrix MJC: Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line. Int J Cancer 47: 227–237, 1991

    Google Scholar 

  24. Mueller BM, Romerdahl CA, Trent JM, Reisfeld RA: Suppression of spontaneous melanoma metastasis in scid mice with an antibody to the epidermal growth factor receptor. Cancer Res 51: 2193–2198, 1991

    Google Scholar 

  25. Mulé JJ, Jicha DL, Aebersold PM, Travis WD, Rosenberg SA: Disseminated human malignant melanoma in congenitally immune deficient (bg/nu/xid) mice. J Natl Cancer Inst 83: 350–355, 1991

    Google Scholar 

  26. Hill LL, Berd D, McCue P, Korngold R: Immunological parameters influencing the primary and metastatic growth of human melanoma in scid mice. FASEB J 5: A965, 1991

  27. Taylor CW, Grogan T, Leong S, Hersh EM: Growth of human malignant melanoma cells in severe combined immune deficient mice. Proc AACR 32: 61, 1991

    Google Scholar 

  28. Garni-Wagner BA, Witte PL, Tutt MM, Kuziel WA, Tucker PW, Bennett M, Kumar V: Natural killer cells in the thymus. Studies in mice with severe combined immune deficiency. J Immunol 144: 796–803, 1990

    Google Scholar 

  29. Bankert RB, Umemoto T, Sugiyama Y, Chen FA, Repasky E, Yokota S: Human lung tumors, patients' peripheral blood lymphocytes and tumor infiltrating lymphocytes propagated in scid mice. Curr Topics Microbiol Immunol 152: 201–210, 1989

    Google Scholar 

  30. Mueller BM, Reisfeld RA: Establishment of human melanoma metastasis in scid/hu mice as a model for immunotherapy. Proc AACR 31: 299, 1990

    Google Scholar 

  31. Gillies SD, Wesolowski JS, Lo KM: Targeting human cytotoxic T lymphocytes to kill heterologous epidermal growth factor receptor-bearing tumor cells. J Immunol 146: 1067–1071, 1991

    Google Scholar 

  32. Gillies SD, Young D, Lo KM, Foley SF, Reisfeld RA: Expression of genetically engineered immunoconjugates of lymphotoxin and a chimeric anti-ganglioside GD2 antibody. Hybridoma 10: 347–356, 1991

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Scripps Research Institute, La Jolla, California, USA

    Barbara M. Mueller & Ralph A. Reisfeld

Authors
  1. Barbara M. Mueller
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ralph A. Reisfeld
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mueller, B.M., Reisfeld, R.A. Potential of the scid mouse as a host for human tumors. Cancer Metast Rev 10, 193–200 (1991). https://doi.org/10.1007/BF00050791

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00050791

Key words

Search

Navigation