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Emerging Roles of Epigenetic Regulators in Maintaining Hematopoietic Stem Cell Homeostasis

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Hematopoietic Stem Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1442))

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Abstract

Hematopoietic stem cells (HSCs) are adult stem cells with the ability of self-renewal and multilineage differentiation into functional blood cells, thus playing important roles in the homeostasis of hematopoiesis and the immune response. Continuous self-renewal of HSCs offers fresh supplies for the HSC pool, which differentiate into all kinds of mature blood cells, supporting the normal functioning of the entire blood system. Nevertheless, dysregulation of the homeostasis of hematopoiesis is often the cause of many blood diseases. Excessive self-renewal of HSCs leads to hematopoietic malignancies (e.g., leukemia), while deficiency in HSC regeneration results in pancytopenia (e.g., anemia). The regulation of hematopoietic homeostasis is finely tuned, and the rapid development of high-throughput sequencing technologies has greatly boosted research in this field. In this chapter, we will summarize the recent understanding of epigenetic regulators including DNA methylation, histone modification, chromosome remodeling, noncoding RNAs, and RNA modification that are involved in hematopoietic homeostasis, which provides fundamental basis for the development of therapeutic strategies against hematopoietic diseases.

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Acknowledgments

This work was supported by grants from the National Key Research and Development Program of China (2022YFA1103500), the National Natural Science Foundation of China (82222003, 92268117, 81870080, 91949115, 82161138028), the Zhejiang Provincial Natural Science Foundation of China (Z24H080001), and the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang (2020R01006).

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The authors declare no competing interests.

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Authors and Affiliations

  1. Center for Stem Cell and Regenerative Medicine and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

    Hui Wang, Yingli Han & Pengxu Qian

  2. Liangzhu Laboratory, Zhejiang University, Hangzhou, China

    Hui Wang, Yingli Han & Pengxu Qian

  3. Institute of Hematology, Zhejiang University & Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Hangzhou, China

    Hui Wang, Yingli Han & Pengxu Qian

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  1. Hui Wang
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  2. Yingli Han
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  3. Pengxu Qian
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Correspondence to Pengxu Qian .

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Editors and Affiliations

  1. Key Laboratory of Stem Cells and Tissue Engineering (Ministry of Education), Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China

    Meng Zhao

  2. Center for Stem Cell and Regenerative Medicine and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

    Pengxu Qian

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Wang, H., Han, Y., Qian, P. (2023). Emerging Roles of Epigenetic Regulators in Maintaining Hematopoietic Stem Cell Homeostasis. In: Zhao, M., Qian, P. (eds) Hematopoietic Stem Cells. Advances in Experimental Medicine and Biology, vol 1442. Springer, Singapore. https://doi.org/10.1007/978-981-99-7471-9_3

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