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Hydrogen Sulfide and the Immune System

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Advances in Hydrogen Sulfide Biology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1315))

Abstract

Hydrogen sulfide (H2S) is the “third gasotransmitter” recognized alongside nitric oxide (NO) and carbon monoxide (CO). H2S exhibits an array of biological effects in mammalian cells as revealed by studies showing important roles in the cardiovascular system, in cell signalling processes, post-translational modifications and in the immune system. Regarding the latter, using pharmacological and genetic approaches scientists have shown this molecule to have both pro- and anti-inflammatory effects in mammalian systems. The anti-inflammatory effects of H2S appeared to be due to its inhibitory action on the nuclear factor kappa beta signalling pathway; NF-kB representing a transcription factor involved in the regulation pro-inflammatory mediators like nitric oxide, prostaglandins, and cytokines. In contrast, results from several animal model describe a more complicated picture and report on pro-inflammatory effects linked to exposure to this molecule; linked to dosage used and point of administration of this molecule. Overall, roles for H2S in several inflammatory diseases spanning arthritis, atherosclerosis, sepsis, and asthma have been described by researchers. In light this work fascinating research, this chapter will cover H2S biology and its many roles in the immune system.

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Authors and Affiliations

  1. School of Biosciences, University of Nottingham, Loughborough, Leicestershire, UK

    Peter Rose

  2. State Key Laboratory of Quality Research in Chinese Medicine and School of Pharmacy, Macau University of Science and Technology, Macau, China

    Peter Rose & Yi-Zhun Zhu

  3. Life Science Institute and Department of Pharmacology, National University of Singapore, Singapore, Singapore

    Philip K. Moore

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  2. Yi-Zhun Zhu
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  3. Philip K. Moore
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Correspondence to Peter Rose .

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  1. Department of Physiology and Pathophysiology, Fudan University Shanghai Medical College, Shanghai Key Laboratory of Bioactive Small Molecules, School of Basic Medical Sciences, Shanghai, China

    Yi-Chun Zhu

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Rose, P., Zhu, YZ., Moore, P.K. (2021). Hydrogen Sulfide and the Immune System. In: Zhu, YC. (eds) Advances in Hydrogen Sulfide Biology. Advances in Experimental Medicine and Biology, vol 1315. Springer, Singapore. https://doi.org/10.1007/978-981-16-0991-6_5

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