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Animal Models of Pancreas Development, Developmental Disorders, and Disease

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Animal Models of Human Birth Defects

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1236))

Abstract

The pancreas is a glandular organ responsible for diverse homeostatic functions, including hormone production from the endocrine islet cells to regulate blood sugar levels and enzyme secretion from the exocrine acinar cells to facilitate food digestion. These pancreatic functions are essential for life; therefore, preserving pancreatic function is of utmost importance. Pancreas dysfunction can arise either from developmental disorders or adult onset disease, both of which are caused by defects in shared molecular pathways. In this chapter, we discuss what is known about the molecular mechanisms controlling pancreas development, how disruption of these mechanisms can lead to developmental defects and disease, and how essential pancreas functions can be modeled using human pluripotent stem cells. At the core of understanding of these molecular processes are animal model studies that continue to be essential for elucidating the mechanisms underlying human pancreatic functions and diseases.

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Acknowledgement

Illustrations in this chapter were drawn by Jennifer Colquhoun.

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Authors and Affiliations

  1. Barbara Davis Center, University of Colorado Anschutz Medical Center, Aurora, CO, USA

    David S. Lorberbaum, Fiona M. Docherty & Lori Sussel

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  1. David S. Lorberbaum
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  2. Fiona M. Docherty
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  3. Lori Sussel
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Correspondence to Lori Sussel .

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  1. Department of Biology, Eberly College of Science and Huck Insitute of Life Sciences, The Pennsylvania State University, University Park, PA, USA

    Aimin Liu

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Lorberbaum, D.S., Docherty, F.M., Sussel, L. (2020). Animal Models of Pancreas Development, Developmental Disorders, and Disease. In: Liu, A. (eds) Animal Models of Human Birth Defects. Advances in Experimental Medicine and Biology, vol 1236. Springer, Singapore. https://doi.org/10.1007/978-981-15-2389-2_3

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