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Mitochondria and Renal Fibrosis

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Renal Fibrosis: Mechanisms and Therapies

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1165))

Abstract

Mitochondria are important organelles in eukaryotic cells and perform a variety of biosynthetic and metabolic functions. Many human diseases are closely related to mitochondrial dysfunction. Kidney is an organ with high-energy requirements, which is distributed with a large number of mitochondria. Mitochondrial dysfunction plays a crucial role in the pathogenesis of kidney disease, and studies have shown that mitochondrial dysfunction is involved in the physiological process of renal fibrosis. This review introduced the biogenesis and pathophysiology of mitochondria, illustrated the involvement of mitochondrial dysfunction in renal fibrosis based on various kinds of cells, and finally summarized the latest mitochondria-targeted therapies.

Mohammed Mazheruddin Quadri and Syeda-Safoorah Fatima contributed equally to this work.

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Authors and Affiliations

  1. Department of Nephrology, Children’s Hospital of Nanjing Medical University, Nanjing, China

    Mohammed Mazheruddin Quadri, Syeda-Safoorah Fatima, Ruo-Chen Che & Ai-Hua Zhang

Authors
  1. Mohammed Mazheruddin Quadri
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  2. Syeda-Safoorah Fatima
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  3. Ruo-Chen Che
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  4. Ai-Hua Zhang
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Corresponding author

Correspondence to Ai-Hua Zhang .

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Editors and Affiliations

  1. Zhongda Hospital, Southeast University School of Medicine, Southeast University, Nanjing, Jiangsu, China

    Bi-Cheng Liu

  2. Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong, Hong Kong

    Hui-Yao Lan

  3. Zhongda Hospital, Southeast University School of Medicine, Southeast University, Nanjing, Jiangsu, China

    Lin-Li Lv

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Quadri, M.M., Fatima, SS., Che, RC., Zhang, AH. (2019). Mitochondria and Renal Fibrosis. In: Liu, BC., Lan, HY., Lv, LL. (eds) Renal Fibrosis: Mechanisms and Therapies. Advances in Experimental Medicine and Biology, vol 1165. Springer, Singapore. https://doi.org/10.1007/978-981-13-8871-2_25

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