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Aldehyde Dehydrogenases pp 107–120Cite as

Mitochondrial Aldehyde Dehydrogenase in Myocardial Ischemic and Ischemia-Reperfusion Injury

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1193))

Abstract

Myocardial ischemia-reperfusion (IR) injury during acute myocardial infarction or open-heart surgery would promote oxidative stress, leading to the accumulation of reactive aldehydes that cause cardiac damage. It has been well demonstrated that aldehyde dehydrogenase (ALDH)-2 is an important cardioprotective enzyme for its central role in the detoxification of reactive aldehydes. ALDH2 activation by small molecule activators is a promising approach for cardioprotection for myocardial IR injury.

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Author notes

  1. Authors Jie Ding and Zheng Yang have been equally contributed to this chapter.

Authors and Affiliations

  1. State Key Laboratory of Cardiovascular Disease, Anesthesia Department, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China

    Jie Ding

  2. Department of Physiology and Pathophysiology, Fourth Military Medical University, Xi’an, China

    Zheng Yang & Heng Ma

  3. Heart Center and Shanghai Institution of Pediatric Congenital Heart Disease, Shanghai Children’s Medical Center, National Children’s Medical Center, Shanghai Jiaotong University School of Medline, Shanghai, China

    Hao Zhang

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  1. Jie Ding
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  4. Hao Zhang
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Correspondence to Heng Ma .

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Editors and Affiliations

  1. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Jun Ren

  2. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Yingmei Zhang

  3. Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai, China

    Junbo Ge

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Ding, J., Yang, Z., Ma, H., Zhang, H. (2019). Mitochondrial Aldehyde Dehydrogenase in Myocardial Ischemic and Ischemia-Reperfusion Injury. In: Ren, J., Zhang, Y., Ge, J. (eds) Aldehyde Dehydrogenases. Advances in Experimental Medicine and Biology, vol 1193. Springer, Singapore. https://doi.org/10.1007/978-981-13-6260-6_6

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