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The Molecular Mechanisms and Prevention Principles of Muscle Atrophy in Aging

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Muscle Atrophy

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1088))

Abstract

Muscle atrophy in aging is characterized by progressive loss of muscle mass and function. Muscle mass is determined by the balance of synthesis and degradation of protein, which are regulated by several signaling pathways such as ubiquitin-proteasome system, autophagy-lysosome systems, oxidative stress, proinflammatory cytokines, hormones, and so on. Sufficient nutrition can enhance protein synthesis, while exercise can improve the quality of life in the elderly. This chapter will discuss the epidemiology, pathogenesis, as well as the current treatment for aging-induced muscular atrophy.

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Acknowledgments

This work was supported by a Jiangsu Province Key Scientific and Technological Project (BE2016669), a Suzhou Science and Technology Project (SS201665), Jiangsu Province Peak of Talent in Six Industries (BU24600117), Jiangsu Province Key Discipline/Laboratory of Medicine (XK201118), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD).

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The authors declare no conflict of interest.

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Authors and Affiliations

  1. Institute for Cardiovascular Science & Department of Cardiovascular Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China

    Yu Zhang & Yangxin Li

  2. Department of Cardiac Surgery, Fuwai Hospital, Beijing, People’s Republic of China

    Xiangbin Pan

  3. Fuwai Yunnan Cardiovascular Hospital, Kunming, Yunnan, People’s Republic of China

    Yi Sun

  4. University of Texas, Houston, TX, USA

    Yong-jian Geng

  5. Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China

    Xi-Yong Yu

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  1. Yu Zhang
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  1. Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China

    Junjie Xiao

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Zhang, Y., Pan, X., Sun, Y., Geng, Yj., Yu, XY., Li, Y. (2018). The Molecular Mechanisms and Prevention Principles of Muscle Atrophy in Aging. In: Xiao, J. (eds) Muscle Atrophy. Advances in Experimental Medicine and Biology, vol 1088. Springer, Singapore. https://doi.org/10.1007/978-981-13-1435-3_16

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