Abstract
Alcohol dependence is a puzzling brain disorder causing enormous suffering and financial costs world-wide. One of the few common denominators of all addictive drugs is activation of the mesolimbic dopamine system resulting in increased dopamine levels in the nucleus accumbens. In order to understand the development of addiction and find new efficient treatment strategies we need to understand how addictive drugs increase dopamine following acute and chronic administration of drugs. In the search for mechanisms underlying ethanol’s ability to increase dopamine in the nucleus accumbens we have found taurine to be of major importance, although the complete picture remains to be disclosed. The aim of the present study was to explore whether chronic voluntary ethanol intake influences the ethanol-induced elevation of taurine. By means of in vivo micro-dialysis we found that voluntary intake of large amounts of ethanol for 12 weeks only had a modest influence on ethanol-induced elevations of taurine in the rat.
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- nAc :
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Nucleus accumbens
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Acknowledgements
The authors are thankful for the technical assistance from Mrs. Rosita Stomberg and Mahmod Panahi. This work was supported by Swedish Medical Research Council (Diary numbers 2014–3888, 2014–3887, and 2015-02894) and the Alcohol Research Council of the Swedish Alcohol Retailing Monopoly.
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Ericson, M., Ulenius, L., Adermark, L., Söderpalm, B. (2017). Minor Adaptations of Ethanol-Induced Release of Taurine Following Chronic Ethanol Intake in the Rat. In: Lee, DH., Schaffer, S.W., Park, E., Kim, H.W. (eds) Taurine 10. Advances in Experimental Medicine and Biology, vol 975. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-1079-2_19
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DOI: https://doi.org/10.1007/978-94-024-1079-2_19
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