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Defective Regulatory Mechanisms in Teratogenesis

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Problems of Birth Defects

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Abstract

Our 16th century colleagues, the animalculists, believed that the germ(cell), the egg or the sperm, carried a small, complete embryo and that its further development merely involved growth of the preformed organism. We may today agree with their basic assumption: the fertilized egg does, in fact, contain all of the informative material for building an individual and no additional instructions are required from outside. Instead of pure growth, however, the development of the zygote involves the gradual expression of the genetic information stored in its DNA, which leads to the specialization of a variety of cell types and tissue complexes with specialized metabolism, form, and structure. As we shall soon see, this synchronous, well timed sequential differentiation is controlled by a great number of different built-in regulatory mechanisms responsible for the creation of a harmonious organism.

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Authors and Affiliations

  1. Third Department of Pathology, University of Helsinki, Helsinki, Finland

    Lauri Saxén M.D., PHil. LIC.

Authors
  1. Lauri Saxén M.D., PHil. LIC.
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Editor information

Editors and Affiliations

  1. Teratology Research Laboratory, University of Manitoba, Canada

    T. V. N. Persaud MD, PhD, DSc, MRCPath, FACOG (Professor of Anatomy and Director, Consultant in Teratology and Pathology) (Professor of Anatomy and Director, Consultant in Teratology and Pathology)

  2. Health Sciences Centre, Winnipeg, Canada

    T. V. N. Persaud MD, PhD, DSc, MRCPath, FACOG (Professor of Anatomy and Director, Consultant in Teratology and Pathology) (Professor of Anatomy and Director, Consultant in Teratology and Pathology)

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© 1970 Williams & Wilkins Co

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Saxén, L. (1970). Defective Regulatory Mechanisms in Teratogenesis. In: Persaud, T.V.N. (eds) Problems of Birth Defects. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-6621-8_8

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  • DOI: https://doi.org/10.1007/978-94-011-6621-8_8

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-011-6623-2

  • Online ISBN: 978-94-011-6621-8

  • eBook Packages: Springer Book Archive

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