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Ovulation Induction with Pulsatile LHRH

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Book cover LHRH and Its Analogs

Abstract

Shortly after LHRH was iso1ated, characterized and synthesized, clinical application to disorders of reproduction and sexual development was initiated. The early experiences with LHRH administered once or twice daily for induction of ovulation were largely unsuccessful.[1,2] The elucidation of the pulsatile release of LHRH by Knobil and colleagues [3] potentiated use of the agent in a physiologic manner and led to the development of successful ovulation induction regimens and pubertal maturation strategies.[4,5] The clinical efficacy of pulsatile LHRH therapy is currently well-documented and it has become an alternative therapy of choice for ovulation induction in patients with suspected hypothalamic suppression.[6–9] Pulsatile LHRH has been reported to be effective in widely variable circumstances including variations in means of administration,[6–9] routes of administration[6,9,10], dosages[6,7], and underlying disease states.[4,11] This paper will review the current experience of LHRH used for ovulation.

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  1. Mayo Medical School, Mayo Foundation, Rochester, MN, 55905, USA

    S. J. Ory

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B. H. Vickery J. J. Nestor Jr.

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Ory, S.J. (1987). Ovulation Induction with Pulsatile LHRH. In: Vickery, B.H., Nestor, J.J. (eds) LHRH and Its Analogs. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-3229-6_21

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  • DOI: https://doi.org/10.1007/978-94-009-3229-6_21

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7949-5

  • Online ISBN: 978-94-009-3229-6

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