Abstract
Daily exposure to extremely low frequency magnetic fields (ELF MF) in the environment has raised public concerns on human health. Epidemiological studies suggest that exposure to ELF MF might associate with an elevated risk of cancer and other diseases in humans. To explain and/or support epidemiological observations, many laboratory studies have been conducted to elucidate the biological effects of ELF MF exposure and the underlying mechanisms of action. In order to reveal the global effects of ELF MF on protein expression, the proteomics approaches has been employed in this research field. In 2005, WHO organized a Workshop on Application of Proteomics and Transcriptomics in electromagnetic fields (EMF) Research in Helsinki, Finland to discuss the related problems and solutions. Later the journal Proteomics published a special issue devoted to the application of proteomics to EMF research. This chapter aims to summarize the current research progress and discuss the applicability of proteomics approaches in studying on ELF MF induced biological effects and the underlying mechanisms.
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References
Feychting M, Ahlbom A, Kheifets L (2005) EMF and health. Annu Rev Public Health 26:165–189
Phillips JL, Haggren W, Thomas WJ, Ishida-Jones T, Adey WR (1992) Magnetic field-induced changes in specific gene transcription. Biochim Biophys Acta 1132(2):140–144
Wei LX, Goodman R, Henderson A (1990) Changes in levels of c-myc and histone H2B following exposure of cells to low-frequency sinusoidal electromagnetic fields: evidence for a window effect. Bioelectromagnetics 11(4):269–272
Leszczynski D, Joenvaara S, Reivinen J, Kuokka R (2002) Non-thermal activation of the hsp27/p38MAPK stress pathway by mobile phone radiation in human endothelial cells: molecular mechanism for cancer- and blood–brain barrier-related effects. Differentiation 70(2–3):120–129
Leszczynski D (2006) The need for a new approach in studies of the biological effects of electromagnetic fields. Proteomics 6(17):4671–4673
Leszczynski D, Meltz ML (2006) Questions and answers concerning applicability of proteomics and transcriptomics in EMF research. Proteomics 6(17):4674–4677
Nakasono S, Saiki H (2000) Effect of ELF magnetic fields on protein synthesis in Escherichia coli K12. Radiat Res 154(2):208–216
Nakasono S, Laramee C, Saiki H, McLeod KJ (2003) Effect of power-frequency magnetic fields on genome-scale gene expression in Saccharomyces cerevisiae. Radiat Res 160(1):25–37
Sinclair J, Weeks M, Butt A, Worthington JL, Akpan A, Jones N, Waterfield M, Allanand D, Timms JF (2006) Proteomic response of Schizosaccharomyces pombe to static and oscillating extremely low-frequency electromagnetic fields. Proteomics 6(17):4755–4764
Li H, Zeng Q, Weng Y, Lu D, Jiang H, Xu Z (2005) Effects of ELF magnetic fields on protein expression profile of human breast cancer cell MCF7. Sci China C Life Sci 48(5):506–514
Kanitz MH, Witzmann FA, Lotz WG, Conover D, Savage RE (2007) Investigation of protein expression in magnetic field-treated human glioma cells. Bioelectromagnetics 28(7):546–552
Sulpizio M, Falone S, Amicarelli F, Marchisio M, Di Giuseppe F, Eleuterio E, Di Ilio C, Angelucci S (2011) Molecular basis underlying the biological effects elicited by extremely low frequency magnetic field (ELF-MF) on neuroblastoma cells. J Cell Biochem 112(12):3797–3806
Goodman R, Blank M (2002) Insights into electromagnetic interaction mechanisms. J Cell Physiol 192(1):16–22
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Chen, G., Xu, Z. (2013). Global Protein Expression in Response to Extremely Low Frequency Magnetic Fields. In: Leszczynski, D. (eds) Radiation Proteomics. Advances in Experimental Medicine and Biology, vol 990. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5896-4_7
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DOI: https://doi.org/10.1007/978-94-007-5896-4_7
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