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A Cross-Bridge Model Describing the Mechanoenergetics of Actomyosin Interaction

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Computer Models in Biomechanics

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Abstract

In order to study the mechanical contraction and energy consumption by the cardiomyocytes we further developed an actomyosin model of Vendelin et al. (Ann. Biomed. Eng. 28:629–640, 2000). The model is of a self-consistent Huxley-type and is based on Hill formalism linking the free energy profile of reactions and mechanical force. In several experimental studies it has been shown that the dependency between oxygen consumption and stress-strain area is linear and is the same for isometric and shortening contractions. We analyzed the free energy profiles of actomyosin interaction by changing free energies of intermediate states and activation of different reactions. The model is able to replicate the linear dependence between oxygen consumption and stress-strain area together with other important mechanical properties of a cardiac muscle.

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Acknowledgements

This research was supported by the European Union through the European Regional Development Fund and by the Estonian Science Foundation (Grant nr. 7344).

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Authors and Affiliations

  1. Laboratory of Systems Biology, Institute of Cybernetics, Tallinn University of Technology, Akadeemia 21, Tallinn, Estonia

    Mari Kalda, Pearu Peterson & Marko Vendelin

  2. Centre for Nonlinear Studies, Institute of Cybernetics, Tallinn University of Technology, Akadeemia 21, Tallinn, Estonia

    Jüri Engelbrecht

Authors
  1. Mari Kalda
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  2. Pearu Peterson
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  3. Jüri Engelbrecht
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  4. Marko Vendelin
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Corresponding author

Correspondence to Jüri Engelbrecht .

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Editors and Affiliations

  1. Institute of Biomechanics, Center of Biomedical Engineering, Graz University of Technology, Kronegasse 5-I, Graz, 8010, Austria

    Gerhard A. Holzapfel

  2. Dept. Mechanical Engineering, Dept. of Bioengineering (courtesy), Stanford University, Lomita Mall 496, Stanford, 94305-4040, California, USA

    Ellen Kuhl

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Kalda, M., Peterson, P., Engelbrecht, J., Vendelin, M. (2013). A Cross-Bridge Model Describing the Mechanoenergetics of Actomyosin Interaction. In: Holzapfel, G., Kuhl, E. (eds) Computer Models in Biomechanics. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5464-5_7

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  • DOI: https://doi.org/10.1007/978-94-007-5464-5_7

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-5463-8

  • Online ISBN: 978-94-007-5464-5

  • eBook Packages: EngineeringEngineering (R0)

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