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Mechanosensory Calcium Signaling

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Calcium Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 740))

Abstract

Mechanotransduction describes the cellular process by which mechanical stimuli are translated into intracellular adaptive responses through biochemical signals. Current research has begun to focus on the once-forgotten organelle, the primary cilia, in this mechanotransduction process. Primary cilia are found on almost every cell type, with a functional role in transducing mechanical and extracellular signals towards intracellular responses through the ciliary extension into the extracellular space. In this regard, the modulation of intracellular calcium signaling by various mechanical stimuli has generated an assortment of attractive models to understand this mechanotransduction process.

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Acknowledgments

Due to restricted space, we apologize to those whose work is not described in this review. Works from our laboratory that are cited in this review have been supported by grants from the National Institutes of Health (DK080640), and the NIH Recovery Act Funds. Authors are grateful to Charisse Montgomery for her editorial support.

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Authors and Affiliations

  1. Department of Pharmacology, The University of Toledo, Health Science Campus; HEB 274, 3000 Arlington Ave.; MS 1015, Toledo, OH, 43614, USA

    Thomas J. Jones & Surya M. Nauli Ph.D.

  2. Departments of Pharmaceutical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH, 44272, USA

    Thomas J. Jones & Surya M. Nauli Ph.D.

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  1. Thomas J. Jones
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  2. Surya M. Nauli Ph.D.
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Correspondence to Surya M. Nauli Ph.D. .

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  1. , Department of Clinical Sciences and Educ, Karolinska Institutet, Tulegatan 26, Stockholm, SE-118 83, Sweden

    Md. Shahidul Islam

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© 2012 Springer Science+Business Media B.V.

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Jones, T.J., Nauli, S.M. (2012). Mechanosensory Calcium Signaling. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 740. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2888-2_46

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