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Portable Chemical Sensors pp 63–94Cite as

Molecular Imprinting for Selective Sensing of Explosives, Warfare Agents, and Toxins

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Abstract

The explosive, warfare agent, and toxin worldwide threats are important hazardous determinants for a safe living environment. The need for better methods of determinations of these compounds generates a strong demand for sensitive, selective, and fast sensing systems. Typically, biorecognition receptors, like enzymes or antibodies, are used to devise biosensors for selective determinations of these compounds. However, these biosensors suffer from several deficiencies. Therefore, synthetic receptors, and particularly those using the concept of molecular ­imprinting, are more and more often being devised as alternatives of the bioreceptors. Among them, the most popular now are molecularly imprinted materials. The present chapter critically evaluates achievements in the development of chemosensing using the imprinting idea for selective determination of biohazardous compounds. Different methods of preparation of synthetic imprinted recognition receptors are scrutinized and various platforms of analytical signal transduction are assessed.

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Abbreviations

AAm:

acrylamide

ACN:

acetonitrile

ACCN:

EGDMA/1,1´-azobis(cyclohexane carbonitrile)

AgNP:

silver nanoparticle

AIBN:

azobis isobutyronitrile

APBA:

3-aminophenylboronic acid

APh:

2-aminophenol

APTMS:

3-aminopropyl trimethoxysilane

2-AThPh:

2-aminothiophenol

4-AThPh:

4-aminothiophenol

ATRS:

attenuated total reflectance spectroscopy

AuNP:

gold nanoparticle

BTEB:

bis(trimethoxysilylethyl)benzene

BWA:

biological warfare agent

CP:

conducting polymer

CV:

cyclic voltammetry

DMF:

N,N-dimethylformamide

DPV:

differential pulse voltammetry

ECP:

electronically conducting polymer

EGDMA:

ethylene glycol dimethacrylate

ELISA:

enzyme-linked immunosorbent assay

GA:

glutaraldehyde

GCE:

glassy carbon electrode

HEPES:

4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid

HMPA:

hexamethylphosphoramide

IA:

itaconic acid

ITMS:

iodotrimethylsilane

ITO:

indium-tin oxide

IOW:

integrated optical waveguide

LBL:

layer-by-layer (transfer)

LOD:

limit of detection

LSV:

linear sweep voltammetry

MA:

methacrylic acid

MIECP:

molecularly imprinted electronically conducting polymer

MIP:

molecularly imprinted polymer

MIPAPBA:

molecularly imprinted poly(aminophenylboronic acid)

MIPEDOT:

molecularly imprinted poly ethylenedioxythiophene

MIPPy:

molecularly imprinted polypyrrole

NIP:

non-imprinted polymer

NOPE:

2-nitrophenyloctyl ether

OTS:

octadecylsiloxane

PANI:

polyaniline

PBS:

phosphate buffer saline

PM:

piezoelectric microgravimetry

PPV:

poly(4-phenylene vinylene)

PVC:

poly(vinyl chloride)

Py:

pyrrole

SAM:

self-assembled monolayer

SCE:

saturated calomel electrode

SDS:

sodium dodecyl sulfate

SERS:

surface enhanced Raman scattering

SPE:

solid phase extraction

SPME:

solid phase microextraction

SPR:

surface plasmon resonance

SWV:

square wave voltammetry

TEOS:

tetraethoxysilane

TMSEPyr:

2-(trimethoxysilylethyl)pyridine

G :

Gibbs free energy

H :

enthalpy

KMIP-A:

stability constant of a complex of the analyte A and the molecular cavity of MIP

S :

entropy

q :

resonance angle

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Acknowledgments

PSS and WK thank the European Regional Development Fund (Project ERDF, POIG.01.01.02-00-008/08 2007–2013, to WK). The work of WK was partially realized within the International PhD Projects Programme of the Foundation for Polish Science, co-financed from European Regional Development Fund within Innovative Economy Operational Program “Grants for innovation”. FD is thankful to the National Science Foundation for the financial support.

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Authors and Affiliations

  1. Department of Physical Chemistry of Supramolecular Complexes, Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224, Warsaw, Poland

    Piyush Sindhu Sharma & Wlodzimierz Kutner

  2. Faculty of Mathematics and Natural Sciences, School of Science, Cardinal Stefan Wyszynski University in Warsaw, Wóycickiego 1/3, 01-815, Warsaw, Poland

    Wlodzimierz Kutner

  3. Department of Chemistry, University of North Texas, 1155, Union Circle, #305070, Denton, TX, 76203-5017, USA

    Francis D’Souza

Authors
  1. Piyush Sindhu Sharma
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  2. Wlodzimierz Kutner
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  3. Francis D’Souza
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Corresponding authors

Correspondence to Wlodzimierz Kutner or Francis D’Souza .

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Editors and Affiliations

  1. , Department of Chemistry, University of Athens, Panepistimiopolis-Kouponia, Athens, 15771, Greece

    Dimitrios Nikolelis

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© 2012 Springer Science+Business Media B.V.

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Sharma, P.S., Kutner, W., D’Souza, F. (2012). Molecular Imprinting for Selective Sensing of Explosives, Warfare Agents, and Toxins. In: Nikolelis, D. (eds) Portable Chemical Sensors. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2872-1_4

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