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Stem Cell Niche

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Regenerative Medicine

Abstract

The adult stem cells are essential for maintaining tissue homeostasis and commonly reside in specific local microenvironment named niche. The niche keeps stem cells in multipotent state, prevents them from precocious differentiation and positions them to undergo asymmetric division to produce differentiated ­progenies for tissue regeneration. The niches employ a variety of factors including cell adhesion molecules, extra cellular matrix, growth factors and cytokines in a tissue-specific manner to regulate the resident stem cells. Stem cells in turn may also contribute to niche integrity and function. Elucidation of stem cell niche regulation at the cellular and molecular level would help understand tissue homeostasis and disease mechanisms, and also provide useful strategies for therapeutic application of stem cells.

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  1. Zhongguancun Life Science Park, National Institute of Biological Sciences, 7 Science Park Road, Beijing, 102206, China

    Pei Wen, Pei Sun & Rongwen Xi

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  1. Pei Wen
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  2. Pei Sun
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Correspondence to Rongwen Xi .

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  1. Klinik und Poliklinik für Herzchirurgie, Universitätsklinikum Rostock, Schillingallee 35, Rostock, 18057, Germany

    Gustav Steinhoff

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Wen, P., Sun, P., Xi, R. (2011). Stem Cell Niche. In: Steinhoff, G. (eds) Regenerative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9075-1_3

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