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The calcitonin gene-related peptide family pp 151–171Cite as

CGRP and Adrenomedullin as Pain-Related Peptides

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Abstract

Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) belongs to the calcitonin gene-related peptide (CGRP) family, with a wide range of distribution and biological functions. CGRP is a well known pain transmitter and modulator highly expressed in primary sensory neurons. In this book chapter, we summarize current data on the role of CGRP in nociception and various types of pain conditions. We also discuss the effectiveness of peptide and non-peptide CGRP antagonists in treating these pathological pain states. Unlike CGRP, the role of AM in nociception and pathological pain conditions remains mostly unknown. However, recent anatomical and pharmacological findings suggest its role in nociception and some pain conditions. Future studies are proposed to uncover the mechanisms underlying the contribution of CGRP and AM in nociception and pathological pain conditions. Developing more selective small molecule antagonists of CGRP and AM receptors should thus be considered as promising therapeutic avenue to effectively treat various pain conditions.

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Abbreviations

AM:

adrenomedullin

AMPA:

alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate

CB1:

cannabinoid 1

CFA:

complete Freund’s adjuvant

CGRP:

calcitonin gene-related peptide

CLR:

calcitonin-like receptor

CREB:

cAMP response element binding protein

DRG:

dorsal root ganglion

GDNF:

glia-derived neurotrophic factor

GSK3ß:

glycogen synthase kinase 3ß

IB4:

isolectin 4

IL-6:

interleukin-6

IL-1β:

interleukin-1β

LPS:

lipopolysccharide

MAPK:

mitogen-activated protein kinase

NGF:

nerve growth factor

NMDA:

N-methyl-D-aspartate

NO:

nitric oxide

PGE2:

prostaglandin E2

PI3K:

phosphatidylinositol 3-kinase

PKA:

protein kinase A

PKC:

protein kinase C

RAMPs:

receptor activity modifying proteins

RCP:

receptor component protein

SP:

substance P

TRPV1:

transient receptor potential vanilloid receptor 1

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Acknowledgements

This study was supported by grants from Canadian Institutes of Health Research to Remi Quirion.

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Authors and Affiliations

  1. Douglas Mental Health University Institute, McGill University, Montreal, Quebec, H4H 1R3, Canada

    Jean-Guy Chabot, Ara Schorscher-Petcu, Yinguo Hong & Zhiyong Wang

  2. Department of Psychiatry, McGill University, Montreal, Quebec, H4H 1R3, Canada

    Weiya Ma & Remi Quirion

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  1. Weiya Ma
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  2. Jean-Guy Chabot
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  3. Ara Schorscher-Petcu
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  4. Yinguo Hong
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  5. Zhiyong Wang
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  6. Remi Quirion
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Corresponding author

Correspondence to Remi Quirion .

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Editors and Affiliations

  1. School of Biological Sciences, University of Auckland, Symonds St. 9, Auckland , 1142, New Zealand

    Deborah L. Hay

  2. University of Auckland, Symonds Street 3A, Auckland, 1142, New Zealand

    Ian M. Dickerson

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Ma, W., Chabot, JG., Schorscher-Petcu, A., Hong, Y., Wang, Z., Quirion, R. (2010). CGRP and Adrenomedullin as Pain-Related Peptides. In: Hay, D., Dickerson, I. (eds) The calcitonin gene-related peptide family. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2909-6_10

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