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Melatonin and Melatonergic Drugs in Clinical Practice pp 367–378Cite as

Jet Lag: Use of Melatonin and Melatonergic Drugs

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Abstract

Jet lag comprises a constellation of symptoms that occurs as a result of disruptions of entrainment associated with time zone transitions. The jet lag symptoms include daytime fatigue, impaired alertness, insomnia, loss of appetite, poor psychomotor coordination, reduced cognitive skills, and depressed mood. The severity of jet lag symptoms depends on the number of time zones crossed as well as the direction of travel. Eastbound travel tends to cause difficulties in falling asleep, whereas westbound travel interferes with sleep maintenance. Clinical studies also indicate that jet lag can exacerbate existing affective disorders. It has been suggested that dysregulation of melatonin secretion and occurrence of circadian rhythm disturbances may be the common links which underlie jet lag and affective disorders. Melatonin has proven to be highly effective for treating the range of symptoms that accompany transmeridian air travel largely because of its regulatory effects on the circadian system. The therapeutic values of melatonin and its agonists such as ramelteon in reducing the jet lag symptoms and use of the melatonergic antidepressant, agomelatine, for jet lag-associated depressive disorders are discussed in this chapter.

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Authors and Affiliations

  1. Sri Sathya Sai Medical Educational and Research Foundation, An International Medical Sciences Research Study Center, Prasanthi Nilayam, 40-Kovai Thirunagar Extn, Goldwins, Coimbatore, TN, 641014, India

    Venkataramanujam Srinivasan MSc, PhD, MAMS

  2. National Health Service, Department of Mental Health, Psychiatric Service of Diagnosis and Treatment, Hospital “G. Mazzini” ASL 4, Teramo, Italy

    Venkataramanujam Srinivasan MSc, PhD, MAMS

  3. Department of Neuroscience and Imaging, University “G.D’ Annunzio”, Chieti, 66013, Italy

    Venkataramanujam Srinivasan MSc, PhD, MAMS

  4. Department of Civil Aviation Medical Board, Civil Aviation Authority of Singapore, Singapore Changi Airport, 1, 918141, Singapore, Singapore

    Jarnail Singh MBBS, Dip Av Med, MSc(OM), FAMS

  5. Department of Obstetrics and Gynecology, Hadassah Hebrew-University Medical Center, Ein-Kerem, Jerusalem, 91120, Israel

    Amnon Brzezinski MD

  6. Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, 16150, Malaysia

    Rahimah Zakaria MBBS, MSc, PhD (Physiology)

  7. Department of Psychiatry and Behavioral Science, Mercer University School of Medicine, 655 First Street, Macon, GA, 31201, USA

    Samuel D. Shillcutt PharmD, PhD

  8. Department of Psychiatry, Faculty of Medicine, University of Toronto, Centre for Addiction and Mental Health, 250, College Street, Toronto, ON, MST 1R8, Canada

    Gregory M. Brown BA, MD, PhD, FRCPC, FRSC

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  1. Venkataramanujam Srinivasan MSc, PhD, MAMS
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Correspondence to Venkataramanujam Srinivasan MSc, PhD, MAMS .

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Editors and Affiliations

  1. Sri Sathya Sai Medical Educational and Research Foundation, An International Medical Sciences Research Center, Coimbatore, Tamil Nadu, India

    V. Srinivasan

  2. Department of Obstetrics and Gynecology, Hadassah Hebrew-University Medical Center, Jerusalem, Israel

    Amnon Brzezinski

  3. Department of Physiology, Gulhane Military Medical Academy, Ankara, Turkey

    Sukru Oter

  4. Department of Psychiatry Behavioral Sciences, Mercer University School of Medicine, Macon, Georgia, USA

    Samuel D. Shillcutt

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Srinivasan, V., Singh, J., Brzezinski, A., Zakaria, R., Shillcutt, S.D., Brown, G.M. (2014). Jet Lag: Use of Melatonin and Melatonergic Drugs. In: Srinivasan, V., Brzezinski, A., Oter, S., Shillcutt, S. (eds) Melatonin and Melatonergic Drugs in Clinical Practice. Springer, New Delhi. https://doi.org/10.1007/978-81-322-0825-9_26

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