Abstract
Although originally proposed as functional tuners capable of influencing signaling thresholds of immune cells, emerging evidence indicates a more central and hierarchical role of glycans and glycan-binding proteins as stimulators or inhibitors of innate and adaptive immunity. An increasing number of studies reveal the relevance of glycan-containing information in host-pathogen recognition and the control of immune cell homeostasis, inflammation, and tumor immunity. In this chapter, we summarize general concepts of glycoimmunology and illustrate selected examples of the contribution of glycans and glycan-binding proteins (C-type lectins, siglecs, and galectins) to innate and adaptive immune responses in physiologic and pathologic settings.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Angata T, Fujinawa R, Kurimoto A et al (2012) Integrated approach toward the discovery of glyco-biomarkers of inflammation-related diseases. Ann N Y Acad Sci 125:159–169
Baum LG, Crocker PR (2009) Glycoimmunology: ignore at your peril! Immunol Rev 230:5–8
Chen HY, Weng IC, Hong MH, Liu FT (2014) Galectins as bacterial sensors in the host innate response. Curr Opin Microbiol 17C:75–81
Clark MC, Baum LG (2012) T cells modulate glycans on CD43 and CD45 during development and activation, signal regulation, and survival. Ann N Y Acad Sci 1253:58–67
Croci DO, Cerliani JP, Dalotto-Moreno T et al (2014) Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors. Cell 156:744–758
Cummings RD, Pierce JM (2014) The challenge and promise of glycomics. Chem Biol 21:1–15
Dennis JW, Lau KS, Demetriou M et al (2009) Adaptive regulation at the cell surface by N-glycosylation. Traffic 10:1569–1578
Geijtenbeek TB, Gringhuis SI (2009) Signaling through C-type lectin receptors: shaping immune responses. Nat Rev Immunol 9:465–479
Hart GW (2013) Nutrient regulation of immunity: O-GlcNAcylation regulates stimulus-specific NF-κB-dependent transcription. Sci Signal 6:pe26
Johnson JL, Jones MB, Ryan SO et al (2013) The regulatory power of glycans and their binding partners in immunity. Trends Immunol 34:290–298
Marth JD, Grewal PK (2008) Mammalian glycosylation in immunity. Nat Rev Immunol 8:874–887
Mendez-Huergo S, Maller SM, Farez MF et al (2014) Integration of lectin–glycan recognition systems and immune cell networks in CNS inflammation. Cytokine Growth Factor Rev. pii: S1359-6101(14)00020-3. doi: 10.1016/j.cytogfr.2014.02.003
Paulson JC, Macauley MS, Kawasaki N (2012) Siglecs as sensors of self in innate and adaptive immune responses. Ann N Y Acad Sci 1253:37–48
Pillai S, Netravali IA, Cariappa A et al (2012) Siglecs and immune regulation. Annu Rev Immunol 30:357–392
Rabinovich GA, Croci DO (2012) Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer. Immunity 36:322–335
Sancho D, Reis e Sousa C (2012) Signaling by myeloid C-type lectin receptors in immunity and homeostasis. Annu Rev Immunol 30:491–529
Sato S, St-Pierre C, Bhaumik P et al (2009) Galectins in innate immunity: dual functions of host soluble beta-galactoside-binding lectins as damage-associated molecular patterns and as receptors for pathogen-associated molecular patterns. Immunol Rev 230:172–187
Shan M, Gentile M, Yeiser JR et al (2013) Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342:447–453
van Kooyk Y, Rabinovich GA (2008) Protein-glycan interactions in the control of innate and adaptive immune responses. Nat Immunol 9:593–601
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer Japan
About this entry
Cite this entry
Blidner, A.G., Ilarregui, J.M., Rabinovich, G.A. (2015). Immunoglycobiology: Overview. In: Taniguchi, N., Endo, T., Hart, G., Seeberger, P., Wong, CH. (eds) Glycoscience: Biology and Medicine. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54841-6_132
Download citation
DOI: https://doi.org/10.1007/978-4-431-54841-6_132
Received:
Accepted:
Published:
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-54840-9
Online ISBN: 978-4-431-54841-6
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences