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Molecular pathways involved in cell death after chemically induced DNA damage

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Molecular, Clinical and Environmental Toxicology

Part of the book series: Experientia Supplementum ((EXS,volume 99))

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Abstract

DNA damage is at the center of the genesis, progression and treatment of cancer. We review here the molecular mechanisms of the DNA damage inducing small molecules most commonly used in cancer therapy. Cell cycle control and DNA repair mechanisms are known to be activated after DNA damage. Here, we revise recent discoveries related to the cell cycle control and DNA repair processes and how these findings are being utilized for the more efficient, powerful and selective therapies for cancer treatment.

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Authors and Affiliations

  1. Instituto de Física, Universidad Autónoma de San Luis Potosí, Mexico

    Roberto Sánchez-Olea & Mónica R. Calera

  2. Department of Biochemistry, Tufts University School of Medicine, Boston, MA, USA

    Alexei Degterev

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  1. Roberto Sánchez-Olea
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  2. Mónica R. Calera
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  3. Alexei Degterev
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  1. Federal Institute for Risk Assessment, Thielallee 88-92, 14195, Berlin, Germany

    Andreas Luch

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Sánchez-Olea, R., Calera, M.R., Degterev, A. (2009). Molecular pathways involved in cell death after chemically induced DNA damage. In: Luch, A. (eds) Molecular, Clinical and Environmental Toxicology. Experientia Supplementum, vol 99. Birkhäuser Basel. https://doi.org/10.1007/978-3-7643-8336-7_8

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