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Molecular Machines Involved in Peroxisome Biogenesis and Maintenance pp 325–345Cite as

Protein Transport In and Out of Plant Peroxisomes

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Abstract

Plant peroxisomes house conserved functions such as β-oxidation and hydrogen peroxide decomposition along with specialized tasks including hormone metabolism and photorespiration. Phenotypes stemming from defects in these pathways have been exploited to isolate and characterize peroxisome-defective mutants in the reference plant Arabidopsis thaliana. Because peroxisome function is essential for plant viability, partial loss-of-function alleles have been frequently recovered from forward genetic screens. Analysis of these mutants has revealed the broad outlines of matrix protein import in plants and that these processes may be more similar between plants and mammals than between plants and yeast. Here we review matrix protein import into plant peroxisomes and the emerging understanding of how these matrix proteins may be degraded when they are damaged or no longer needed.

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References

  • Adham AR, Zolman BK, Millius A, Bartel B (2005) Mutations in Arabidopsis acyl-CoA oxidase genes reveal distinct and overlapping roles in β-oxidation. Plant J 41:859–874

    Article  CAS  PubMed  Google Scholar 

  • Agne B, Meindl NM, Niederhoff K, Einwächter H, Rehling P, Sickmann A, Meyer HE, Girzalsky W, Kunau W-H (2003) Pex8p: an intraperoxisomal organizer of the peroxisomal import machinery. Mol Cell 11:635–646

    Article  CAS  PubMed  Google Scholar 

  • Albertini M, Rehling P, Erdmann R, Girzalsky W, Kiel JAKW, Veenhuis M, Kunau WH (1997) Pex14p, a peroxisomal membrane protein binding both receptors of the two PTS-dependent import pathways. Cell 89:83–92

    Article  CAS  PubMed  Google Scholar 

  • Alonso JM, Stepanova AN, Leisse TJ, Kim CJ, Chen H, Shinn P, Stevenson DK, Zimmerman J, Barajas P, Cheuk R, Gadrinab C, Heller C, Jeske A, Koesema E, Meyers CC, Parker H, Prednis L, Ansari Y, Choy N, Deen H, Geralt M, Hazari N, Hom E, Karnes M, Mulholland C, Ndubaku R, Schmidt I, Guzman P, Aguilar-Henonin L, Schmid M, Weigel D, Carter DE, Marchand T, Risseeuw E, Brogden D, Zeko A, Crosby WL, Berry CC, Ecker JR (2003) Genome-wide insertional mutagenesis of Arabidopsis thaliana. Science 301:653–657

    Article  PubMed  Google Scholar 

  • Boisson-Dernier A, Frietsch S, Kim T-H, Dizon MB, Schroeder JI (2008) The peroxin loss-of-function mutation abstinence by mutual consent disrupts recognition between male and female gametophytes. Curr Biol 18:63–68

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Braverman N, Dodt G, Gould SJ, Valle D (1998) An isoform of Pex5p, the human PTS1 receptor, is required for the import of PTS2 proteins into peroxisomes. Hum Mol Genet 7:1195–1205

    Article  CAS  PubMed  Google Scholar 

  • Burkhart SE, Lingard MJ, Bartel B (2013) Genetic dissection of peroxisome-associated matrix protein degradation in Arabidopsis thaliana. Genetics 193:125–141

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Cui S, Fukao Y, Mano S, Yamada K, Hayashi M, Nishimura M (2013) Proteomic analysis reveals that the Rab GTPase RabE1c is involved in the degradation of the peroxisomal protein receptor PEX7 (peroxin 7). J Biol Chem 288:6014–6023

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Dodt G, Warren D, Becker E, Rehling P, Gould SJ (2001) Domain mapping of human PEX5 reveals functional and structural similarities to Saccharomyces cerevisiae Pex18p and Pex21p. J Biol Chem 276:41769–41781

    Article  CAS  PubMed  Google Scholar 

  • Eastmond PJ (2006) SUGAR-DEPENDENT1 encodes a patatin domain triacylglycerol lipase that initiates storage oil breakdown in germinating Arabidopsis seeds. Plant Cell 18:665–675

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Eastmond PJ (2007) MONODEHYROASCORBATE REDUCTASE4 is required for seed storage oil hydrolysis and postgerminative growth in Arabidopsis. Plant Cell 19:1376–1387

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Eubel H, Meyer EH, Taylor NL, Bussell JD, O’Toole N, Heazlewood JL, Castleden I, Small ID, Smith SM, Millar AH (2008) Novel proteins, putative membrane transporters, and an integrated metabolic network are revealed by quantitative proteomic analysis of Arabidopsis cell culture peroxisomes. Plant Physiol 148:1809–1829

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Fan J, Quan S, Orth T, Awai C, Chory J, Hu J (2005) The Arabidopsis PEX12 gene is required for peroxisome biogenesis and is essential for development. Plant Physiol 139:231–239

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Farmer LM, Rinaldi MA, Young PG, Danan CH, Burkhart SE, Bartel B (2013) Disrupting autophagy restores peroxisome function to an Arabidopsis lon2 mutant and reveals a role for the LON2 protease in peroxisomal matrix protein degradation. Plant Cell 25:4085–4100

    Article  CAS  PubMed  Google Scholar 

  • Faust JE, Verma A, Peng C, McNew JA (2012) An inventory of peroxisomal proteins and pathways in Drosophila melanogaster. Traffic 13:1378–1392

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Fujiki Y, Nashiro C, Miyata N, Tamura S, Okumoto K (2012) New insights into dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p in shuttling of PTS1-receptor Pex5p during peroxisome biogenesis. Biochim Biophys Acta 1823:145–149

    Article  CAS  PubMed  Google Scholar 

  • Gatto GJ Jr, Geisbrecht BV, Gould SJ, Berg JM (2000) Peroxisomal targeting signal-1 recognition by the TPR domains of human PEX5. Nat Struct Biol 7:1091–1095

    Article  CAS  PubMed  Google Scholar 

  • Gietl C, Faber KN, van der Klei IJ, Veenhuis M (1994) Mutational analysis of the N-terminal topogenic signal of watermelon glyoxysomal malate dehydrogenase using the heterologous host Hansenula polymorpha. Proc Natl Acad Sci USA 91:3151–3155

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Goto S, Mano S, Nakamori C, Nishimura M (2011) Arabidopsis ABERRANT PEROXISOME MORPHOLOGY9 is a peroxin that recruits the PEX1-PEX6 complex to peroxisomes. Plant Cell 23:1573–1587

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Gould SJ, Keller GA, Subramani S (1988) Identification of peroxisomal targeting signals located at the carboxy terminus of four peroxisomal proteins. J Cell Biol 107:897–905

    Article  CAS  PubMed  Google Scholar 

  • Graham IA, Eastmond PJ (2002) Pathways of straight and branched chain fatty acid catabolism in higher plants. Prog Lipid Res 41:156–181

    Article  CAS  PubMed  Google Scholar 

  • Grimm I, Saffian D, Platta HW, Erdmann R (2012) The AAA-type ATPases Pex1p and Pex6p and their role in peroxisomal matrix protein import in Saccharomyces cerevisiae. Biochim Biophys Acta 1823:150–158

    Article  CAS  PubMed  Google Scholar 

  • Gurvitz A, Langer S, Piskacek M, Hamilton B, Ruis H, Hartig A (2000) Predicting the function and subcellular location of Caenorhabditis elegans proteins similar to Saccharomyces cerevisiae β-oxidation enzymes. Yeast 17:188–200

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hampton RY, Sommer T (2012) Finding the will and the way of ERAD substrate retrotranslocation. Curr Opin Cell Biol 24:460–466

    Article  CAS  PubMed  Google Scholar 

  • Hayashi M, Toriyama K, Kondo M, Nishimura M (1998) 2,4-dichlorophenoxybutyric acid-resistant mutants of Arabidopsis have defects in glyoxysomal fatty acid β-oxidation. Plant Cell 10:183–195

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hayashi M, Nito K, Toriyama-Kato K, Kondo M, Yamaya T, Nishimura M (2000a) AtPex14p maintains peroxisomal functions by determining protein targeting to three kinds of plant peroxisomes. EMBO J 19:5701–5710

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hayashi M, Toriyama K, Kondo K, Kato A, Mano S, De Bellis L, Hayashi-Ishimaru Y, Yamaguchi K, Hayashi H, Nishimura M (2000b) Functional transformation of plant peroxisomes. Cell Biochem Biophys 32:295–304

    Article  CAS  PubMed  Google Scholar 

  • Hayashi H, Nito K, Takei-Hoshi R, Yagi M, Kondo M, Suenaga A, Yamaya T, Nishimura M (2002) Ped3p is a peroxisomal ATP-binding cassette transporter that might supply substrates for fatty acid β-oxidation. Plant Cell Physiol 43:1–11

    Article  CAS  PubMed  Google Scholar 

  • Hayashi M, Yagi M, Nito K, Kamada T, Nishimura M (2005) Differential contribution of two peroxisomal protein receptors to the maintenance of peroxisomal functions in Arabidopsis. J Biol Chem 280:14829–14835

    Article  CAS  PubMed  Google Scholar 

  • Heiland I, Erdmann R (2005) Biogenesis of peroxisomes. Topogenesis of the peroxisomal membrane and matrix proteins. FEBS J 272:2362–2372

    Article  CAS  PubMed  Google Scholar 

  • Helm M, Lück C, Prestele J, Hierl G, Huesgen PF, Frohlich T, Arnold GJ, Adamska I, Görg A, Lottspeich F, Gietl C (2007) Dual specificities of the glyoxysomal/peroxisomal processing protease DEG15 in higher plants. Proc Natl Acad Sci USA 104:11501–11506

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Hijikata M, Ishii N, Kagamiyama H, Osumi T, Hashimoto T (1987) Structural analysis of cDNA for rat peroxisomal 3-ketoacyl-CoA thiolase. J Biol Chem 262:8151–8158

    CAS  PubMed  Google Scholar 

  • Hu J, Aguirre M, Peto C, Alonso J, Ecker J, Chory J (2002) A role for peroxisomes in photomorphogenesis and development of Arabidopsis. Science 297:405–409

    Article  CAS  PubMed  Google Scholar 

  • Hu J, Baker A, Bartel B, Linka N, Mullen RT, Reumann S, Zolman BK (2012) Plant peroxisomes: biogenesis and function. Plant Cell 24:2279–2303

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Johnson TL, Olsen LJ (2003) Import of the peroxisomal targeting signal type 2 protein 3-ketoacyl-Coenzyme A thiolase into glyoxysomes. Plant Physiol 133:1991–1999

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Kaur N, Zhao Q, Xie Q, Hu J (2013) Arabidopsis RING peroxins are E3 ubiquitin ligases that interact with two homologous ubiquitin receptor proteins. J Integr Plant Biol 55:108–120

    Article  CAS  PubMed  Google Scholar 

  • Khan BR, Zolman BK (2010) pex5 mutants that differentially disrupt PTS1 and PTS2 peroxisomal matrix protein import in Arabidopsis. Plant Physiol 154:1602–1615

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Kim J, Lee H, Lee HN, Kim SH, Shin KD, Chung T (2013) Autophagy-related proteins are required for degradation of peroxisomes in Arabidopsis hypocotyls during seedling growth. Plant Cell 25:4956–4966

    Article  CAS  PubMed  Google Scholar 

  • Krysan PJ, Young JC, Sussman MR (1999) T-DNA as an insertional mutagen in Arabidopsis. Plant Cell 11:2283–2290

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Lee JR, Jang HH, Park JH, Jung JH, Lee SS, Park SK, Chi YH, Moon JC, Lee YM, Kim SY, Kim JY, Yun DJ, Cho MJ, Lee KO, Lee SY (2006) Cloning of two splice variants of the rice PTS1 receptor, OsPex5pL and OsPex5pS, and their functional characterization using pex5-deficient yeast and Arabidopsis. Plant J 47:457–466

    Article  CAS  PubMed  Google Scholar 

  • Li F, Vierstra RD (2012) Autophagy: a multifaceted intracellular system for bulk and selective recycling. Trends Plant Sci 17:526–537

    Article  CAS  PubMed  Google Scholar 

  • Lin Y, Sun L, Nguyen LV, Rachubinski RA, Goodman HM (1999) The Pex16p homolog SSE1 and storage organelle formation in Arabidopsis seeds. Science 284:328–330

    Article  CAS  PubMed  Google Scholar 

  • Lin Y, Ulanov AV, Lozovaya V, Widholm J, Zhang G, Guo J, Goodman HM (2006) Genetic and transgenic perturbations of carbon reserve production in Arabidopsis seeds reveal metabolic interactions of biochemical pathways. Planta 225:153–164

    Article  CAS  PubMed  Google Scholar 

  • Lingard MJ, Bartel B (2009) Arabidopsis LON2 is necessary for peroxisomal function and sustained matrix protein import. Plant Physiol 151:1354–1365

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Lingard MJ, Monroe-Augustus M, Bartel B (2009) Peroxisome-associated matrix protein degradation in Arabidopsis. Proc Natl Acad Sci USA 106:4561–4566

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Lisenbee CS, Lingard MJ, Trelease RN (2005) Arabidopsis peroxisomes possess functionally redundant membrane and matrix isoforms of monodehydroascorbate reductase. Plant J 43:900–914

    Article  CAS  PubMed  Google Scholar 

  • Mano S, Nakamori C, Kondo M, Hayashi M, Nishimura M (2004) An Arabidopsis dynamin-related protein, DRP3A, controls both peroxisomal and mitochondrial division. Plant J 38:487–498

    Article  CAS  PubMed  Google Scholar 

  • Mano S, Nakamori C, Nito K, Kondo M, Nishimura M (2006) The Arabidopsis pex12 and pex13 mutants are defective in both PTS1- and PTS2-dependent protein transport to peroxisomes. Plant J 47:604–618

    Article  CAS  PubMed  Google Scholar 

  • Mano S, Nakamori C, Fukao Y, Araki M, Matsuda A, Kondo M, Nishimura M (2011) A defect of peroxisomal membrane protein 38 causes enlargement of peroxisomes. Plant Cell Physiol 52:2157–2172

    Article  CAS  PubMed  Google Scholar 

  • Matsumura T, Otera H, Fujiki Y (2000) Disruption of the interaction of the longer isoform of Pex5p, Pex5pL, with Pex7p abolishes peroxisome targeting signal type 2 protein import in mammals. Study with a novel PEX5-impaired Chinese hamster ovary cell mutant. J Biol Chem 275:21715–21721

    Article  CAS  PubMed  Google Scholar 

  • Meinecke M, Cizmowski C, Schliebs W, Kruger V, Beck S, Wagner R, Erdmann R (2010) The peroxisomal importomer constitutes a large and highly dynamic pore. Nat Cell Biol 3:273–277

    Google Scholar 

  • Mhamdi A, Noctor G, Baker A (2012) Plant catalases: peroxisomal redox guardians. Arch Biochem Biophys 525:181–194

    Article  CAS  PubMed  Google Scholar 

  • Monroe-Augustus M (2004) Genetic approaches to elucidating the mechanisms of indole-3-acetic acid and indole-3-butyric acid function in Arabidopsis thaliana. Ph.D. Rice University, Houston

    Google Scholar 

  • Monroe-Augustus M, Ramón NM, Ratzel SE, Lingard MJ, Christensen SE, Murali C, Bartel B (2011) Matrix proteins are inefficiently imported into Arabidopsis peroxisomes lacking the receptor-docking peroxin PEX14. Plant Mol Biol 77:1–15

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Motley AM, Hettema EH, Ketting R, Plasterk R, Tabak HF (2000) Caenorhabditis elegans has a single pathway to target matrix proteins to peroxisomes. EMBO Rep 1:40–46

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Nito K, Hayashi M, Nishimura M (2002) Direct interaction and determination of binding domains among peroxisomal import factors in Arabidopsis thaliana. Plant Cell Physiol 43:355–366

    Article  CAS  PubMed  Google Scholar 

  • Nito K, Kamigaki A, Kondo M, Hayashi M, Nishimura M (2007) Functional classification of Arabidopsis peroxisome biogenesis factors proposed from analyses of knockdown mutants. Plant Cell Physiol 48:763–774

    Article  CAS  PubMed  Google Scholar 

  • Ostersetzer O, Kato Y, Adam Z, Sakamoto W (2007) Multiple intracellular locations of Lon protease in Arabidopsis: evidence for the localization of AtLon4 to chloroplasts. Plant Cell Physiol 48:881–885

    Article  CAS  PubMed  Google Scholar 

  • Otera H, Okumoto K, Tateishi K, Ikoma Y, Matsuda E, Nishimura M, Tsukamoto T, Osumi T, Ohashi K, Higuchi O, Fujiki Y (1998) Peroxisome targeting signal type 1 (PTS1) receptor is involved in import of both PTS1 and PTS2: Studies with PEX5-defective CHO cell mutants. Mol Cell Biol 18:388–399

    CAS  PubMed Central  PubMed  Google Scholar 

  • Otera H, Harano T, Honsho M, Ghaedi K, Mukai S, Tanaka A, Kawai A, Shimizu N, Fujiki Y (2000) The mammalian peroxin Pex5pL, the longer isoform of the mobile peroxisome targeting signal (PTS) Type 1 transporter, translocates the Pex7p-PTS2 protein complex into peroxisomes via its initial docking site, Pex14p. J Biol Chem 275:21703–21714

    Article  CAS  PubMed  Google Scholar 

  • Platta HW, El Magraoui F, Schlee D, Grunau S, Girzalsky W, Erdmann R (2007) Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling. J Cell Biol 177:197–204

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Platta HW, Magraoui FE, Baumer BE, Schlee D, Girzalsky W, Erdmann R (2009) Pex2 and Pex12 function as protein-ubiquitin ligases in peroxisomal protein import. Mol Cell Biol 29:5505–5516

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Prestele J, Hierl G, Scherling C, Hetkamp S, Schwechheimer C, Isono E, Weckwerth W, Wanner G, Gietl C (2010) Different functions of the C3HC4 zinc RING finger peroxins PEX10, PEX2, and PEX12 in peroxisome formation and matrix protein import. Proc Natl Acad Sci USA 107:14915–14920

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Purdue PE, Yang X, Lazarow PB (1998) Pex18p and Pex21p, a novel pair of related peroxins essential for peroxisomal targeting by the PTS2 pathway. J Cell Biol 143:1859–1869

    Article  CAS  PubMed  Google Scholar 

  • Ramón NM, Bartel B (2010) Interdependence of the peroxisome-targeting receptors in Arabidopsis thaliana: PEX7 facilitates PEX5 accumulation and import of PTS1 cargo into peroxisomes. Mol Biol Cell 21:1263–1271

    Article  PubMed Central  PubMed  Google Scholar 

  • Ratzel SE, Lingard MJ, Woodward AW, Bartel B (2011) Reducing PEX13 expression ameliorates physiological defects of late-acting peroxin mutants. Traffic 12:121–134

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Reumann S, Babujee L, Ma C, Wienkoop S, Siemsen T, Antonicelli GE, Rasche N, Luder F, Weckwerth W, Jahn O (2007) Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Plant Cell 19:3170–3193

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Schliebs W, Girzalsky W, Erdmann R (2010) Peroxisomal protein import and ERAD: variations on a common theme. Nat Rev Mol Cell Biol 11:885–890

    Article  CAS  PubMed  Google Scholar 

  • Schluter A, Fourcade S, Ripp R, Mandel JL, Poch O, Pujol A (2006) The evolutionary origin of peroxisomes: an ER-peroxisome connection. Mol Biol Evol 23:838–845

    Article  CAS  PubMed  Google Scholar 

  • Schumann U, Wanner G, Veenhuis M, Schmid M, Gietl C (2003) AthPEX10, a nuclear gene essential for peroxisome and storage organelle formation during Arabidopsis embryogenesis. Proc Natl Acad Sci USA 100:9626–9631

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Schumann U, Prestele J, O’Geen H, Brueggeman R, Wanner G, Gietl C (2007) Requirement of the C3HC4 zinc RING finger of the Arabidopsis PEX10 for photorespiration and leaf peroxisome contact with chloroplasts. Proc Natl Acad Sci USA 104:1069–1074

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Schumann H, Huesgen PF, Gietl C, Adamska I (2008) The DEG15 serine protease cleaves peroxisomal targeting signal 2-containing proteins in Arabidopsis. Plant J 148:1847–1856

    Google Scholar 

  • Sharp PA (1999) RNAi and double-stranded RNA. Genes Dev 13:139–141

    Article  CAS  PubMed  Google Scholar 

  • Shibata M, Oikawa K, Yoshimoto K, Kondo M, Mano S, Yamada K, Hayashi M, Sakamoto W, Ohsumi Y, Nishimura M (2013) Highly oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis. Plant Cell 25(12):4967–4983

    Article  CAS  PubMed  Google Scholar 

  • Shimizu N, Itoh R, Hirono Y, Otera H, Ghaedi K, Tateishi K, Tamura S, Okumoto K, Harano T, Mukai S, Fujiki Y (1999) The peroxin Pex14p. cDNA cloning by functional complementation on a Chinese hamster ovary cell mutant, characterization, and functional analysis. J Biol Chem 274:12593–12604

    Article  CAS  PubMed  Google Scholar 

  • Singh T, Hayashi M, Mano S, Arai Y, Goto S, Nishimura M (2009) Molecular components required for the targeting of PEX7 to peroxisomes in Arabidopsis thaliana. Plant J 60:488–498

    Article  CAS  PubMed  Google Scholar 

  • Sparkes IA, Brandizzi F, Slocombe SP, El-Shami M, Hawes C, Baker A (2003) An Arabidopsis pex10 null mutant is embryo lethal, implicating peroxisomes in an essential role during plant embryogenesis. Plant Physiol 133:1809–1819

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Strader LC, Bartel B (2011) Transport and metabolism of the endogenous auxin precursor indole-3-butyric acid. Mol Plant 4:477–486

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Strader L, Culler Hendrickson A, Cohen J, Bartel B (2010) Conversion of endogenous indole-3-butyric acid to indole-3-acetic acid drives cell expansion in Arabidopsis seedlings. Plant Physiol 153:1577–1586

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Strader LC, Wheeler DL, Christensen SE, Berens JC, Cohen JD, Rampey RA, Bartel B (2011) Multiple facets of Arabidopsis seedling development require indole-3-butyric acid-derived auxin. Plant Cell 23:984–999

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Swinkels BW, Gould SJ, Bodnar AG, Rachubinski RA, Subramani S (1991) A novel, cleavable peroxisomal targeting signal at the amino-terminus of the rat 3-ketoacyl-CoA thiolase. EMBO J 10:3255–3262

    CAS  PubMed Central  PubMed  Google Scholar 

  • Thoms S, Erdmann R (2006) Peroxisomal matrix protein receptor ubiquitination and recycling. Biochim Biophys Acta 1763:1620–1628

    Article  CAS  PubMed  Google Scholar 

  • Till A, Lakhani R, Burnett SF, Subramani S (2012) Pexophagy: the selective degradation of peroxisomes. Int J Cell Biol 2012:512721

    Article  PubMed Central  PubMed  Google Scholar 

  • Toro AA, Araya CA, Cordova GJ, Arredondo CA, Cardenas HG, Moreno RE, Venegas A, Koenig CS, Cancino J, Gonzalez A, Santos MJ (2009) Pex3p-dependent peroxisomal biogenesis initiates in the endoplasmic reticulum of human fibroblasts. J Cell Biochem 107:1083–1096

    Article  CAS  PubMed  Google Scholar 

  • Wain RL, Wightman F (1954) The growth-regulating activity of certain ω-substituted alkyl carboxylic acids in relation to their β-oxidation within the plant. Proc R Soc London Ser B 142:525–536

    Article  CAS  Google Scholar 

  • Woodward AW, Bartel B (2005a) The Arabidopsis peroxisomal targeting signal type 2 receptor PEX7 is necessary for peroxisome function and dependent on PEX5. Mol Biol Cell 16:573–583

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Woodward AW, Bartel B (2005b) Auxin: regulation, action, and interaction. Ann Bot 95:707–735

    Article  CAS  PubMed  Google Scholar 

  • Woodward AW, Fleming WA, Ratzel SE, Burkhart SE, Bjornson M, Bartel B (2014) A viable Arabidopsis pex13 missense allele confers severe peroxisomal defects and decreases PEX5 association with peroxisomes. Plant Mol Biol (in revision)

    Google Scholar 

  • Zolman BK, Bartel B (2004) An Arabidopsis indole-3-butyric acid-response mutant defective in PEROXIN6, an apparent ATPase implicated in peroxisomal function. Proc Natl Acad Sci USA 101:1786–1791

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Zolman BK, Yoder A, Bartel B (2000) Genetic analysis of indole-3-butyric acid responses in Arabidopsis thaliana reveals four mutant classes. Genetics 156:1323–1337

    CAS  PubMed Central  PubMed  Google Scholar 

  • Zolman BK, Silva ID, Bartel B (2001) The Arabidopsis pxa1 mutant is defective in an ATP-binding cassette transporter-like protein required for peroxisomal fatty acid b-oxidation. Plant Physiol 127:1266–1278

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Zolman BK, Monroe-Augustus M, Silva ID, Bartel B (2005) Identification and functional characterization of Arabidopsis PEROXIN4 and the interacting protein PEROXIN22. Plant Cell 17:3422–3435

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Zolman BK, Nyberg M, Bartel B (2007) IBR3, a novel peroxisomal acyl-CoA dehydrogenase-like protein required for indole-3-butyric acid response. Plant Mol Biol 64:59–72

    Article  CAS  PubMed  Google Scholar 

  • Zolman BK, Martinez N, Millius A, Adham AR, Bartel B (2008) Identification and characterization of Arabidopsis indole-3-butyric acid response mutants defective in novel peroxisomal enzymes. Genetics 180:237–251

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Acknowledgments

We apologize to those whose work we were unable to discuss due to space limitations. We thank Kim Gonzalez, Yun-Ting Kao, Mauro Rinaldi, Andrew Woodward, and Pierce Young for critical comments on the manuscript. Confocal microscopy was performed on equipment obtained through a Shared Instrumentation Grant from the National Institutes of Health (S10RR026399). The authors’ research is supported by the National Institutes of Health (R01-GM079177), the National Science Foundation (MCB-0745122 and MCB-1244182), and the Robert A. Welch Foundation (C-1309).

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  1. Department of Biochemistry and Cell Biology, Rice University, 6100 Main Street, Houston, TX, 77005, USA

    Bonnie Bartel, Sarah E. Burkhart & Wendell A. Fleming

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  1. Bonnie Bartel
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  2. Sarah E. Burkhart
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  3. Wendell A. Fleming
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Correspondence to Bonnie Bartel .

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  1. Mauerbach, Austria

    Cecile Brocard

  2. Max F. Perutz Laboratories University of Vienna, Vienna, Austria

    Andreas Hartig

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Bartel, B., Burkhart, S.E., Fleming, W.A. (2014). Protein Transport In and Out of Plant Peroxisomes. In: Brocard, C., Hartig, A. (eds) Molecular Machines Involved in Peroxisome Biogenesis and Maintenance. Springer, Vienna. https://doi.org/10.1007/978-3-7091-1788-0_14

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