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Abstract

An important behavioral pattern that can be witnessed in many systems is periodic re-occurrence. For example, most living organisms that we know are governed by a 24 hours rhythm that determines whether they are awake or not. On a larger scale, also whole population numbers of organisms fluctuate in a cyclic manner as in predator-prey relationships. When treating such systems in a deterministic way, i.e., assuming that stochastic effects are negligible, the analysis is a well-studied topic. But if those effects play an important role, recent publications suggest that at least a part of the system should be modeled stochastically. However, in that case, one quickly realizes that characterizing and defining oscillatory behavior is not a straightforward task, which can be solved once and for all. Moreover, efficiently checking whether a given system oscillates or not and if so determining the amplitude of the fluctuations and the time in-between is intricate. This paper shall give an overview of the existing literature on different modeling formalisms for oscillatory systems, definitions of oscillatory behavior, and the respective analysis methods.

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References

  1. de Alfaro, L., Roy, P.: Magnifying-lens abstraction for Markov decision processes. In: Damm, W., Hermanns, H. (eds.) CAV 2007. LNCS, vol. 4590, pp. 325–338. Springer, Heidelberg (2007)

    Chapter  Google Scholar 

  2. Alfonsi, A., Cancès, E., Turinici, G., Di Ventura, B., Huisinga, W.: Exact simulation of hybrid stochastic and deterministic models for biochemical systems. Research Report RR-5435, INRIA (2004)

    Google Scholar 

  3. Alfonsi, A., Cancès, E., Turinici, G., Ventura, B.D., Huisinga, W.: Adaptive simulation of hybrid stochastic and deterministic models for biochemical systems. ESAIM: Proc., 14:1–14:13 (2005)

    Google Scholar 

  4. Alur, R., Dill, D.L.: A theory of timed automata. Theoretical Computer Science 126(2), 183–235 (1994)

    Article  MathSciNet  MATH  Google Scholar 

  5. Aris, R.: Prolegomena to the rational analysis of systems of chemical reactions. Archive for Rational Mechanics and Analysis 19, 81–99 (1965)

    Article  MathSciNet  Google Scholar 

  6. Arkin, A., Ross, J., McAdams, H.H.: Stochastic kinetic analysis of developmental pathway bifurcation in phage lambda-infected escherichia coli cells. Genetics 149(4), 1633–1648 (1998)

    Google Scholar 

  7. Arns, M., Buchholz, P., Panchenko, A.: On the numerical analysis of inhomogeneous continuous-time Markov chains. INFORMS Journal on Computing 22(3), 416–432 (2009)

    Article  MathSciNet  MATH  Google Scholar 

  8. Baier, C., Haverkort, B., Hermanns, H., Katoen, J.-P.: Model-checking algorithms for continuous-time Markov chains. IEEE Transactions on Software Engineering 29(6), 524–541 (2003)

    Article  MATH  Google Scholar 

  9. Baier, C., Katoen, J.-P.: Principles of Model Checking. The MIT Press (2008)

    Google Scholar 

  10. Ball, K., Kurtz, T.G., Popovic, L., Rempala, G.: Asymptotic analysis of multiscale approximations to reaction networks. The Annals of Applied Probability 16(4), 1925–1961 (2006)

    Article  MathSciNet  MATH  Google Scholar 

  11. Ballarini, P., Guerriero, M.L.: Query-based verification of qualitative trends and oscillations in biochemical systems. Theoretical Computer Science 411(20), 2019–2036 (2010)

    Article  MathSciNet  MATH  Google Scholar 

  12. Ballarini, P., Mardare, R., Mura, I.: Analysing biochemical oscillation through probabilistic model checking. ENTCS 229(1), 3–19 (2009)

    MathSciNet  MATH  Google Scholar 

  13. Barkai, N., Leibler, S.: Biological rhythms: Circadian clocks limited by noise. Nature 403, 267–268 (2000)

    Google Scholar 

  14. Bartocci, E., Corradini, F., Merelli, E., Tesei, L.: Model checking biological oscillators. ENTCS 229(1), 41–58 (2009)

    MathSciNet  MATH  Google Scholar 

  15. Burrage, K., Hegland, M., Macnamara, S., Sidje, R.: A Krylov-based finite state projection algorithm for solving the chemical master equation arising in the discrete modeling of biological systems. In: Langville, A.N., Stewart, W.J. (eds.) Markov Anniversary Meeting 2006: An International Conference to Celebrate the 150th Anniversary of the Birth of A. A. Markov, pp. 21–38. Boston Books, Charleston (2006)

    Google Scholar 

  16. Burrage, K., Tian, T.: Poisson Runge-Kutta methods for chemical reaction systems. In: Lu, Y., Sun, W., Tang, T. (eds.) Advances in Scientific Computing and Applications, pp. 82–96. Science Press, Beijing (2004)

    Google Scholar 

  17. Burrage, K., Tian, T., Burrage, P.: A multi-scaled approach for simulating chemical reaction systems. Progress in Biophysics and Molecular Biology 85(2-3), 217–234 (2004)

    Article  Google Scholar 

  18. Cao, Y., Gillespie, D.T., Petzold, L.R.: The slow-scale stochastic simulation algorithm. The Journal of Chemical Physics 122(1), 014116 (2005)

    Google Scholar 

  19. Cardelli, L.: Artificial biochemistry. Technical report, Microsoft Research (2006)

    Google Scholar 

  20. Cardelli, L.: Artificial biochemistry. In: Algorithmic Bioproceses. LNCS. Springer (2008)

    Google Scholar 

  21. Casagrande, A., Mysore, V., Piazza, C., Mishra, B.: Independent dynamics hybrid automata in systems biology. In: Proceedings of the First International Conference on Algebraic Biology, pp. 61–73. Universal Academy Press, Tokyo (2005)

    Google Scholar 

  22. Chabrier-Rivier, N., Chiaverini, M., Danos, V., Fages, F., Schächter, V.: Modeling and querying biomolecular interaction networks. Theoretical Computer Science 325, 25–44 (2003)

    Article  MathSciNet  MATH  Google Scholar 

  23. Chellaboina, V., Bhat, S., Haddad, W., Bernstein, D.: Modeling and analysis of mass-action kinetics. IEEE Control Systems Magazine 29(4), 60–78 (2009)

    Article  MathSciNet  Google Scholar 

  24. Clarke, E.M., Emerson, E.A.: Design and synthesis of synchronization skeletons using branching-time temporal logic. In: Logic of Programs, pp. 52–71. Springer, London (1982)

    Chapter  Google Scholar 

  25. Cloth, L., Katoen, J.-P., Khattri, M., Pulungan, R.: Model-checking Markov reward models with impulse rewards. In: DSN, Yokohama (2005)

    Google Scholar 

  26. Crudu, A., Debussche, A., Radulescu, O.: Hybrid stochastic simplifications for multiscale gene networks. BMC Systems Biology 3(1), 89 (2009)

    Article  Google Scholar 

  27. D’Argenio, P.R., Jeannet, B., Jensen, H.E., Larsen, K.G.: Reachability analysis of probabilistic systems by successive refinements. In: de Luca, L., Gilmore, S. (eds.) PAPM-PROBMIV 2001. LNCS, vol. 2165, pp. 39–56. Springer, Heidelberg (2001)

    Google Scholar 

  28. Dayar, T., Mikeev, L., Wolf, V.: On the numerical analysis of stochastic Lotka-Volterra models. In: IMCSIT, pp. 289–296 (2010)

    Google Scholar 

  29. de Jong, H.: Modeling and simulation of genetic regulatory systems: A literature review. Journal of Computational Biology 9(1), 67–103 (2002)

    Article  Google Scholar 

  30. Didier, F., Henzinger, T.A., Mateescu, M., Wolf, V.: Fast adaptive uniformization of the chemical master equation. In: Proc., HIBI 2009, pp. 118–127. IEEE Computer Society, Washington, DC (2009)

    Google Scholar 

  31. Elowitz, M.B.: Stochastic gene expression in a single cell. Science 297(5584), 1183–1186 (2002)

    Article  Google Scholar 

  32. Elowitz, M.B., Leibler, S.: A synthetic oscillatory network of transcriptional regulators. Nature 403(6767), 335–338 (2000)

    Article  Google Scholar 

  33. Ferrell, J.E., Tsai, T.Y.-C., Yang, Q.: Modeling the cell cycle: Why do certain circuits oscillate? Cell 144(6), 874–885 (2011)

    Article  Google Scholar 

  34. Gardner, T.S., Cantor, C.R., Collins, J.J.: Construction of a genetic toggle switch in Escherichia coli. Nature 403(6767), 339–342 (2000)

    Article  Google Scholar 

  35. Gibson, M.A., Bruck, J.: Efficient exact stochastic simulation of chemical systems with many species and many channels. The Journal of Physical Chemistry A 104(9), 1876–1889 (2000)

    Article  Google Scholar 

  36. Gillespie, D.T.: A general method for numerically simulating the stochastic time evolution of coupled chemical reactions. Journal of Computational Physics 22(4), 403–434 (1976)

    Article  MathSciNet  Google Scholar 

  37. Gillespie, D.T.: Exact stochastic simulation of coupled chemical reactions. The Journal of Physical Chemistry 81(25), 2340–2361 (1977)

    Article  Google Scholar 

  38. Gillespie, D.T.: A rigorous derivation of the chemical master equation. Physica A 188, 404–425 (1992)

    Article  Google Scholar 

  39. Gillespie, D.T.: Approximate accelerated stochastic simulation of chemically reacting systems. The Journal of Chemical Physics 115(4), 1716 (2001)

    Article  Google Scholar 

  40. Glass, L., Beuter, A., Larocque, D.: Time delays, oscillations, and chaos in physiological control systems. Mathematical Biosciences 90(1-2), 111–125 (1988)

    Article  MathSciNet  MATH  Google Scholar 

  41. Goldbeter, A.: A model for circadian oscillations in the drosophila period protein (PER). Proceedings of the Royal Society B: Biological Sciences 261(1362), 319–324 (1995)

    Article  Google Scholar 

  42. Goldbeter, A.: Computational approaches to cellular rhythms. Nature 420(6912), 238–245 (2002)

    Article  Google Scholar 

  43. Gonze, D., Halloy, J., Goldbeter, A.: Deterministic versus stochastic models for circadian rhythms. Journal of Biological Physics 28(4), 637–653 (2002)

    Article  Google Scholar 

  44. Grassmann, W.: Finding transient solutions in Markovian event systems through randomization. In: The First International Conference on the Numerical Solution of Markov Chains, pp. 375–385 (1990)

    Google Scholar 

  45. Griffith, M., Courtney, T., Peccoud, J., Sanders, W.H.: Dynamic partitioning for hybrid simulation of the bistable HIV-1 transactivation network. Bioinformatics 22(22), 2782–2789 (2006)

    Article  Google Scholar 

  46. Gross, D., Miller, D.R.: The randomization technique as a modeling tool and solution procedure for transient Markov processes. Operations Research 32(2), 343–361 (1984)

    Article  MathSciNet  MATH  Google Scholar 

  47. Guerriero, M.L., Heath, J.K.: Computational modeling of biological pathways by executable biology. Methods in Enzymology 487, 217–251 (2011)

    Article  Google Scholar 

  48. Henzinger, T.A., Mateescu, M., Wolf, V.: Sliding window abstraction for infinite Markov chains. In: Bouajjani, A., Maler, O. (eds.) CAV 2009. LNCS, vol. 5643, pp. 337–352. Springer, Heidelberg (2009)

    Chapter  Google Scholar 

  49. Henzinger, T.A., Mikeev, L., Mateescu, M., Wolf, V.: Hybrid numerical solution of the chemical master equation. In: Proc., CMSB 2010, pp. 55–65. ACM, New York (2010)

    Google Scholar 

  50. Higgins, J.: The theory of oscillating reactions. Industrial and Engineering Chemistry 59, 18–62 (1967)

    Article  Google Scholar 

  51. Horn, F., Jackson, R.: General mass action kinetics. ARMA 47, 81–116 (1972)

    Article  MathSciNet  Google Scholar 

  52. Horton, G., Kulkarni, V.G., Nicol, D.M., Trivedi, K.S.: Fluid stochastic Petri nets: Theory, applications, and solution techniques. European Journal of Operational Research 105(1), 184–201 (1998)

    Article  MATH  Google Scholar 

  53. Lohmueller, J., et al.: Progress toward construction and modelling of a tri-stable toggle switch in e. coli. IET Synthetic Biology 1(1.2), 25–28 (2007)

    Article  Google Scholar 

  54. Jahnke, T., Huisinga, W.: Solving the chemical master equation for monomolecular reaction systems analytically. Journal of Mathematical Biology 54(1), 1–26 (2006)

    Article  MathSciNet  MATH  Google Scholar 

  55. Jensen, A.: Markoff chains as an aid in the study of Markoff processes. Scandinavian Actuarial Journal 1953(suppl. 1), 87–91 (1953)

    Google Scholar 

  56. Kampen, N.V.: Stochastic processes in physics and chemistry. North Holland (2007)

    Google Scholar 

  57. Katoen, J.-P., Klink, D., Leucker, M., Wolf, V.: Three-valued abstraction for continuous-time Markov chains. In: Damm, W., Hermanns, H. (eds.) CAV 2007. LNCS, vol. 4590, pp. 311–324. Springer, Heidelberg (2007)

    Chapter  Google Scholar 

  58. Kolmogoroff, A.: Über die analytischen Methoden in der Wahrscheinlichkeitsrechnung. Mathematische Annalen 104, 415–458 (1931)

    Article  MathSciNet  MATH  Google Scholar 

  59. Kowalewski, S., Engell, S., Stursberg, O.: On the generation of timed discrete approximations for continuous systems. MCMDS 6(1), 51–70 (2000)

    Article  MATH  Google Scholar 

  60. Krishna, S.: Minimal model of spiky oscillations in NF-κb signaling. PNAS 103(29), 10840–10845 (2006)

    Article  Google Scholar 

  61. Kummer, U., Krajnc, B., Pahle, J., Green, A.K., Dixon, C.J., Marhl, M.: Transition from stochastic to deterministic behavior in calcium oscillations. Biophysical Journal 89(3), 1603–1611 (2005)

    Article  Google Scholar 

  62. Kurtz, T.G.: The Relationship between Stochastic and Deterministic Models for Chemical Reactions. The Journal of Chemical Physics 57(7), 2976–2978 (1972)

    Article  Google Scholar 

  63. Kwiatkowska, M., Norman, G., Pacheco, A.: Model checking expected time and expected reward formulae with random time bounds. In: Proc. 2nd Euro-Japanese Workshop on Stochastic Risk Modelling for Finance, Insurance, Production and Reliability (2002)

    Google Scholar 

  64. Kwiatkowska, M., Norman, G., Parker, D.: Game-based abstraction for Markov decision processes. In: Proc. QEST, pp. 157–166. IEEE CS Press (2006)

    Google Scholar 

  65. Kwiatkowska, M., Norman, G., Parker, D.: PRISM 4.0: Verification of probabilistic real-time systems. In: Gopalakrishnan, G., Qadeer, S. (eds.) CAV 2011. LNCS, vol. 6806, pp. 585–591. Springer, Heidelberg (2011)

    Chapter  Google Scholar 

  66. Lapin, M., Mikeev, L., Wolf, V.: SHAVE – Stochastic hybrid analysis of Markov population models. In: Proc. HSCC. ACM, New York (2011)

    Google Scholar 

  67. Leloup, J.C.: Toward a detailed computational model for the mammalian circadian clock. PNAS 100(12), 7051–7056 (2003)

    Article  Google Scholar 

  68. Leloup, J.C., Gonze, D., Goldbeter, A.: Limit cycle models for circadian rhythms based on transcriptional regulation in drosophila and neurospora. Journal of Biological Rhythms 14(6), 433–448 (1999)

    Article  Google Scholar 

  69. Lewis, J.: Autoinhibition with transcriptional delay: A simple mechanism for the zebrafish somitogenesis oscillator. Current Biology 13(16), 1398–1408 (2003)

    Article  Google Scholar 

  70. Lotka, A.: Elements of mathematical biology. Dover Publications (1956); Reprinted from Lotka, A.J. Elements of physical biology (1924)

    Google Scholar 

  71. Maler, O., Batt, G.: Approximating continuous systems by timed automata. In: Fisher, J. (ed.) FMSB 2008. LNCS (LNBI), vol. 5054, pp. 77–89. Springer, Heidelberg (2008)

    Chapter  Google Scholar 

  72. Martiel, J.-L., Goldbeter, A.: A model based on receptor desensitization for cyclic AMP signaling in dictyostelium cells. Biophysical Journal 52(5), 807–828 (1987)

    Article  MATH  Google Scholar 

  73. MATLAB. Version 7.11.0.584 (R2010b). The MathWorks Inc., Natick, Massachusetts (2010)

    Google Scholar 

  74. McAdams, H.H., Arkin, A.: Stochastic mechanisms in gene expression. Proceedings of the National Academy of Sciences of the United States of America 94(3), 814–819 (1997)

    Article  Google Scholar 

  75. Menz, S., Latorre, J.C., Schtte, C., Huisinga, W.: Hybrid stochastic–deterministic solution of the chemical master equation. MMS 10(4), 1232–1262 (2012)

    Article  MathSciNet  MATH  Google Scholar 

  76. Meyer, K.M., Wiegand, K., Ward, D., Moustakas, A.: SATCHMO: A spatial simulation model of growth, competition, and mortality in cycling savanna patches. Ecological Modelling 209(24), 377–391 (2007)

    Article  Google Scholar 

  77. Mikeev, L., Neuhäußer, M.R., Spieler, D., Wolf, V.: On-the-fly verification and optimization of DTA-properties for large Markov chains. FMSD, 1–25 (2012)

    Google Scholar 

  78. Mincheva, M.: Oscillations in non-mass action kinetics models of biochemical reaction networks arising from pairs of subnetworks. Journal of Mathematical Chemistry 50(5), 1111–1125 (2011)

    Article  MathSciNet  MATH  Google Scholar 

  79. van Moorsel, A.P.A., Wolter, K.: Numerical solution of non-homogeneous Markov processes through uniformization. In: Proceedings of the 12th European Simulation Multiconference on Simulation - Past, Present and Future, pp. 710–717. SCS Europe (1998)

    Google Scholar 

  80. Munsky, B., Khammash, M.: The finite state projection algorithm for the solution of the chemical master equation. The Journal of Chemical Physics 124(4), 044104 (2006)

    Google Scholar 

  81. Murray, J.D.: Mathematical Biology. Springer, New York (1993)

    Book  MATH  Google Scholar 

  82. Nakano, S., Yamaguchi, S.: Two modeling methods for signaling pathways with multiple signals using uppaal. Proc. BioPPN, 87–101 (2011)

    Google Scholar 

  83. Parker, D.: PRISM Tutorial - Circadian Clock, http://www.prismmodelchecker.org/tutorial/circadian.php

  84. Piazza, C., Antoniotti, M., Mysore, V., Policriti, A., Winkler, F., Mishra, B.: Algorithmic algebraic model checking I: Challenges from systems biology. In: Etessami, K., Rajamani, S.K. (eds.) CAV 2005. LNCS, vol. 3576, pp. 5–19. Springer, Heidelberg (2005)

    Chapter  Google Scholar 

  85. Pnueli, A.: The temporal logic of programs. In: Proc., SFCS, pp. 46–57. IEEE Computer Society, Washington, DC (1977)

    Google Scholar 

  86. Rao, C.V., Arkin, A.P.: Stochastic chemical kinetics and the quasi-steady-state assumption: Application to the Gillespie algorithm. The Journal of Chemical Physics 118(11), 4999 (2003)

    Article  Google Scholar 

  87. Reppert, S.M., Weaver, D.R.: Coordination of circadian timing in mammals. Nature 418(6901), 935–941 (2002)

    Article  Google Scholar 

  88. Salis, H., Kaznessis, Y.: Accurate hybrid stochastic simulation of a system of coupled chemical or biochemical reactions. The Journal of Chemical Physics 122(5), 54103 (2005)

    Article  Google Scholar 

  89. Sanft, K., Gillespie, D., Petzold, L.: Legitimacy of the stochastic Michaelis Menten approximation. IET Systems Biology 5(1), 58 (2011)

    Article  Google Scholar 

  90. Schivo, S., et al.: Modelling biological pathway dynamics with timed automata. In: BIBE, pp. 447–453. IEEE (2012)

    Google Scholar 

  91. Schuster, S., Marhl, M., Höfer, T.: Modelling of simple and complex calcium oscillations. European Journal of Biochemistry 269(5), 1333–1355 (2002)

    Article  Google Scholar 

  92. Singh, A., Hespanha, J.P.: Stochastic hybrid systems for studying biochemical processes. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences 368(1930), 4995–5011 (2010)

    Article  MathSciNet  MATH  Google Scholar 

  93. Smolen, P., Hardin, P.E., Lo, B.S., Baxter, D.A., Byrne, J.H.: Simulation of drosophila circadian oscillations, mutations, and light responses by a model with VRI, PDP-1, and CLK. Biophysical Journal 86(5), 2786–2802 (2004)

    Article  Google Scholar 

  94. Somogyi, R., Stucki, J.W.: Hormone-induced calcium oscillations in liver cells can be explained by a simple one pool model. Journal of Biological Chemistry 266(17), 11068–11077 (1991)

    Google Scholar 

  95. Spieler, D.: Model checking of oscillatory and noisy periodic behavior in Markovian population models. Technical report, Saarland University (2009), Master thesis available at http://mosi.cs.uni-saarland.de/?page_id=93

  96. Steinfeld, J., Francisco, J., Hase, W.: Chemical kinetics and dynamics. Prentice Hall (1989)

    Google Scholar 

  97. Stiver, J.A., Antsaklis, P.J.: State space partitioning for hybrid control systems. In: American Control Conference, pp. 2303–2304. IEEE (1993)

    Google Scholar 

  98. Tang, Y., Othmer, H.G.: Excitation, oscillations and wave propagation in a G-protein-based model of signal transduction in dictyostelium discoideum. Philosophical Transactions of the Royal Society B: Biological Sciences 349(1328), 179–195 (1995)

    Article  Google Scholar 

  99. Tyson, J.J.: Biological switches and clocks. Journal of the Royal Society Interface 5, S1–S8 (2008)

    Google Scholar 

  100. van Dijk, N.M.: Uniformization for nonhomogeneous Markov chains. Operations Research Letters 12(5), 283–291 (1992)

    Article  MathSciNet  MATH  Google Scholar 

  101. Vilar, J., Kueh, H.-Y., Barkai, N., Leibler, S.: Mechanisms of noise-resistance in genetic oscillators. PNAS 99(9), 5988–5992 (2002)

    Article  Google Scholar 

  102. Volterra, V.: Fluctuations in the abundance of a species considered mathematically. Nature 118, 558–560 (1926)

    Article  MATH  Google Scholar 

  103. Wagner, H., Möller, M., Prank, K.: COAST: controllable approximative stochastic reaction algorithm. The Journal of Chemical Physics 125(17), 174104 (2006)

    Article  Google Scholar 

  104. Wolkenhauer, O., Ullah, M., Kolch, W., Cho, K.-H.: Modeling and simulation of intracellular dynamics: Choosing an appropriate framework. IEEE Transactions on Nanobioscience 3(3), 200–207 (2004)

    Article  Google Scholar 

  105. Zeilinger, M.N., Farr, E.M., Taylor, S.R., Kay, S.A., Doyle, F.J.: A novel computational model of the circadian clock in arabidopsis that incorporates PRR7 and PRR9. Molecular Systems Biology 2 (2006)

    Google Scholar 

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Andreychenko, A., Krüger, T., Spieler, D. (2014). Analyzing Oscillatory Behavior with Formal Methods. In: Remke, A., Stoelinga, M. (eds) Stochastic Model Checking. Rigorous Dependability Analysis Using Model Checking Techniques for Stochastic Systems. ROCKS 2012. Lecture Notes in Computer Science, vol 8453. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45489-3_1

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