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Structural Studies on Adenoviruses

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Adenoviruses: Model and Vectors in Virus-Host Interactions

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 272))

Abstract

The adenovirus genome encodes more than 40 proteins, of which 11 combine with the viral DNA to form an icosahedral capsid of ~ 150 MDa molecular weight and ~ 900 Å in diameter. This chapter reviews the information that structural biology techniques have provided about the adenovirus proteins and capsid. The structures of two capsid proteins (hexon and fiber) and two non-structural polypeptides (DNA-binding protein and protease) have been solved by X-ray crystallography. Fiber and its knob have been the focus of the latest structural studies, due to their role in host recognition and conseqnently in virus targeting for human gene therapy.The current model for hte large capsid comes from a combination of electron microscopy and crystallogrphy. The resultand imgaes have revealed a surprising similarity between adenovirus and a bacterial virus, Which suggests their common evolutionary origin.

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  1. The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA

    C. San Martín & R. M. Burnett

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  1. Institut für Klinische und Molekulare Virologie, Universität Erlangen-Nürnberg, 91054, Erlangen, Germany

    Walter Doerfler

  2. Institut für Genetik, Universität zu Köln, Weyertal 121, 50931, Köln, Germany

    Petra Böhm

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Martín, C.S., Burnett, R.M. (2003). Structural Studies on Adenoviruses. In: Doerfler, W., Böhm, P. (eds) Adenoviruses: Model and Vectors in Virus-Host Interactions. Current Topics in Microbiology and Immunology, vol 272. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05597-7_3

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