Abstract
Estrogens play a central role in mammalian physiology by regulating the differentiation, growth, and maintenance of a wide variety of tissues. For more than thirty years, it was generally assumed that estrogens exerted their myriad effects by binding to and activating a single estrogen receptor (ER), the estrogen receptor α (ERα; Green et al. 1986; Greene et al. 1986). This assumption was proven incorrect with the cloning and identification of a second estrogen receptor subtype, estrogen receptor β(ERβ; Kuiper et al. 1996; Mosselman et al. 1996; Tremblay et al. 1997).
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Greene, G.L., Shiau, A.K., Nettles, K.W. (2004). A Structural Explanation for ERα/ERβ SERM Discrimination. In: Korach, K.S., Hillisch, A., Fritzemeier, K.H. (eds) New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy. Ernst Schering Research Foundation Workshop, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05386-7_3
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DOI: https://doi.org/10.1007/978-3-662-05386-7_3
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