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Terminal Myeloid Gene Expression and Differentiation Requires the Transcription Factor PU.1

  • Conference paper
Book cover Molecular Aspects of Myeloid Stem Cell Development

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 211))

Abstract

Hematopoiesis is a multi-stage developmental process which yields at least eight distinct lineages including monocytes, granulocytes, lymphocytes, megakaryocytes, and erythrocytes. During myelopoiesis, pluripotent hematopoietic stem cells become committed as myeloid precursor cells which differentiate into morphologically and functionally distinct end-stage macrophages and neutrophils. Multipotent progenitors differentiate into macrophages through successive intermediates involving monoblasts, promonocytes, monocytes, and then macrophages. Granulocytic development involves the differentiation of progenitors into myeloblasts, promyelocytes, myelocytes, and then neutrophils. Hematopoiesis in the developing mouse embryo is initiated in the yolk sac on the seventh day of gestation. Primitive macrophages first appear in yolk sac blood islands on day 9, bypassing the differentiation pathway of the monocytic series, to become fetal macrophages in various tissues [13, 22].

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Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, University of Chicago, Chicago, IL, 60637, USA

    M. C. Simon, M. Olson, E. Scott, A. Hack & H. Singh

  2. Department of Medicine, University of Chicago, Chicago, IL, 60637, USA

    M. C. Simon

  3. Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, IL, 60637, USA

    M. C. Simon & H. Singh

  4. Department of Committee on Immunology, University of Chicago, Chicago, IL, 60637, USA

    M. C. Simon, G. Su & H. Singh

Authors
  1. M. C. Simon
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  2. M. Olson
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  3. E. Scott
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  4. A. Hack
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  5. G. Su
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  6. H. Singh
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bldg. 37, Rm. 1 B16, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA

    Linda Wolff Ph.D. (Senior Investigator) (Senior Investigator)

  2. Department of Pathology, Yale University School of Medicine, P.O. Box 208023, New Haven, CT, 06520-8023, USA

    Archibald S. Perkins M.D., Ph.D. (Assistant Professor) (Assistant Professor)

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© 1996 Springer-Verlag Berlin Heidelberg

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Simon, M.C., Olson, M., Scott, E., Hack, A., Su, G., Singh, H. (1996). Terminal Myeloid Gene Expression and Differentiation Requires the Transcription Factor PU.1. In: Wolff, L., Perkins, A.S. (eds) Molecular Aspects of Myeloid Stem Cell Development. Current Topics in Microbiology and Immunology, vol 211. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85232-9_11

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  • DOI: https://doi.org/10.1007/978-3-642-85232-9_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85234-3

  • Online ISBN: 978-3-642-85232-9

  • eBook Packages: Springer Book Archive

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