Skip to main content
SpringerLink
Log in

Silicone Gel and Octamethylcyclotetrasiloxane Potentiate Antibody Production to Bovine Serum Albumin in Mice

  • Conference paper
Immunology of Silicones

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 210))

Abstract

Earlier studies, in the rat, have shown that silicone gel acts as a potent adjuvant for antibody production against bovine serum albumin (BSA). The purpose of the present study is to determine whether components of the silicone breast implant (silicone oil, silicone gel, and octamethylcyclotetrasiloxane [D4]) potentiate the antibody response to BSA in mice. Groups of ten A/J mice received a single subcutaneous injection of 0.1 ml of BSA emulsified with the following: a) silicone preparations, b) incomplete Freund’s adjuvant, or c) saline alone. Antibodies to BSA were measured using an enzyme-linked immunosorbant assay. The results indicate that both D4 and the silicone gel potentiate antibody production to BSA in mice. Known adjuvants have been shown to induce autoimmune syndromes in animal models. Whether silicones can act in a similar mechanism is still unclear.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Dr. Rose has served as expert witness on behalf of defendants in several legal proceedings involving silicone breast implants. He has also served as consultant for Mentor Corporation, a manufacturer of breast implants.

    Google Scholar 

  2. Vasey FB, Havice DL, Bocsnegra TS, et al (1994) Clinical and immunologic findings in fifty consecutive women with silicone breast implants and connective tissue disease. Semin Arthritis Rheum 24 (1 Suppl l):22–28

    Article  PubMed  CAS  Google Scholar 

  3. Sahn EE, Garen PD, Silver, et al. (1990) Scleroderma following augmentation mammoplasty: report of case and review of the literature. Arch Dermatol 126:1198–1202

    Article  PubMed  CAS  Google Scholar 

  4. Shons AR, Schubert W (1992) Silicone breast implants and immune disease. Ann Plast Surg 28:491–499

    Article  PubMed  CAS  Google Scholar 

  5. Miyoshi K, Miyaoki T, Kobayashi Y, et al. (1962) Hypergammaglobulinemia by prolonged adjuvanticity in man: disorders developed after augmentation mammoplasty. Jap Med J: 2122, 9–14

    Google Scholar 

  6. Miyoshi K, Miyaoki T, Kobayashi Y (1973) Adjuvant disease in man. Clin Immunol 5:785–794

    Google Scholar 

  7. Pearson CM (1956) Development of arthritis, periarthritis, and periostitis in rats given adjuvants. Proc Soc Exp Med 91:95–100

    CAS  Google Scholar 

  8. Pearson CM, Wood FD (1981) Studies of polyarthritis and other lesions induced in rats by injection of mycobacterial adjuvant. I. General clinical and pathological characteristics and some modifying factors. Arthritis Rheum 2:440–459

    Article  Google Scholar 

  9. Nairn JO, Lanzafame, van Oss CJ (1993) The adjuvant effect of silicone gel on antibody formation in rats. Immunol Invest 22: 151

    Article  Google Scholar 

  10. Wilkerson P (1992) Report presented before the General and Plastic Surgery Device Evaluation Panel, FDA, Bethesda, MD, February 1992

    Google Scholar 

  11. Roitt IM (1994) Essential immunology. Blackwell Scientific Publications, Boston

    Google Scholar 

  12. Le Vier RR. Discussion of: Semple JL, Narini PP, Hay JB (193) Preparation techniques for silicone gel in the evaluation of its in vivo effects. Plast Reconstr Surg 92(5):979–81

    Google Scholar 

  13. Rose NR, Freidman H, Fahey JL, Eds (1986) Manual of clinical laboratory immunology, 3rd Ed. American Society for Microbiology, Washington, D.C.

    Google Scholar 

  14. Ratkay LG, Zhang L, Tonzetich J, Waterfield JD (1993) Complete Freund’s adjuvantinduces an earlier and more severe arthritis in MRL-lpr mice. Journal of Immunol 151(9):5081–7

    CAS  Google Scholar 

  15. Lopez-Guerrero JA, Lopez-Bote JP, Ortiz MA, et al (1993) Modulation of adjuvant arthritis in Lewis rats by recombinant vaccinia virus expressing the human 60-kiladalton heat shock protein. Infect Immun 61(10):4225–31

    PubMed  CAS  Google Scholar 

  16. van Eden W (1991) Heat-shock proteins as immunogenic bacterial antigens with the potential to induce and regulate autoimmune arthritis. Immunol Rev 121:5–28

    Article  PubMed  Google Scholar 

  17. Koga T, Pearson CM, Narita T, Kotani S (1973) Polyarthrities induced in the rats with cell walls from several bacteria and two streptomyces species. Proc Soc Exp Biol Med 143: 824

    PubMed  CAS  Google Scholar 

  18. Whitehouse MW, Orr KJ, Beck FWJ, Pearson CM (1974) Freund’s adjuvants: relationship of arthritogenicity and adjuvanticity in rats to vehicle composition. Immunol 27:311

    CAS  Google Scholar 

  19. Kleinau S, Erlandsson H, Klareskog L (1994) Percutaneous exposure of adjuvant oil causes arthritis in DA rats. Clin Exp Immunol 96:281–284.

    Article  PubMed  CAS  Google Scholar 

  20. Perretti M, Mudridge KG, Becherucci C, Parente L (1991) Evidence that interleukin-1 and lipoxygenase metabolites mediate the lethal effect of complete Freund’s adjuvant in adrenalectomized rats. Lymphokine Cytokine Res 10(4): 239–43

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Microbiology and Immunology, Johns Hopkins University, USA

    J. J. Nicholson III, C. G. Frondoza & N. R. Rose

  2. Department of Molecular Microbiology and Biology, Johns Hopkins University, USA

    G. E. Wong

  3. Department of Molecular Microbiology and Orthopaedic Surgery, Johns Hopkins University, USA

    C. G. Frondoza

  4. Department of Molecular Microbiology and Pathology, Johns Hopkins University, USA

    N. R. Rose

Authors
  1. J. J. Nicholson III
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. E. Wong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. G. Frondoza
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. N. R. Rose
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, Bldg. 37, Rm. 2B04, 37 Convent Drive MSC 4255, Bethesda, MD, 20892-4255, USA

    Michael Potter M.D. (Chief) (Chief)

  2. Departments of Pathology and of Molecular Microbiology and Immunology, John Hopkins University, 615 N. Wolfe Street, Rm. 4027, Baltimore, MD, 21205, USA

    Noel R. Rose M.D. Ph.D. (Professor of Pathology and Molecular Microbiology and Immunology) (Professor of Pathology and Molecular Microbiology and Immunology)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Nicholson, J.J., Wong, G.E., Frondoza, C.G., Rose, N.R. (1996). Silicone Gel and Octamethylcyclotetrasiloxane Potentiate Antibody Production to Bovine Serum Albumin in Mice. In: Potter, M., Rose, N.R. (eds) Immunology of Silicones. Current Topics in Microbiology and Immunology, vol 210. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85226-8_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-85226-8_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85228-2

  • Online ISBN: 978-3-642-85226-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation