Skip to main content

Predictive Assays for Tumor Response to Single and Multiple Fractions of Hyperthermia

  • Conference paper
Preclinical Hyperthermia

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 109))

Abstract

Local regional hyperthermia is currently being tested clinically in combination with radiation therapy or chemotherapy. The results of several clinical trials show that for superficial tumors, hyperthermia used in conjunction with radiotherapy improves the response rate over radiotherapy alone (Overgaard 1985).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anderson RL, Tao TW, Hahn GM (1984) Cholesterol-phospholipid ratios decrease in heat resistant variants of B 16 melanoma cells. In: Overgaard J (ed) Hyperthermic oncology, vol 1. Taylor and Francis, London, pp 123–126

    Google Scholar 

  • Anderson RL, Tao TW, Betten DA, Hahn GM (1986) Heat shock protein levels are not elevated in heat-resistant B 16 melanoma cells. Radiat. Res. 105: 240–246

    Article  PubMed  CAS  Google Scholar 

  • Calderwood SK, Stevenson MA, Hahn GM (1985) Cyclic AMP and the heat shock response in Chinese hamster ovary cells. Biochem. Biophys. Res Comm 126: 912–916

    Article  Google Scholar 

  • Edidin M, Weiss A (1972) Antigen cap formation in cultured fibroblasts: a reflection of membrane fluidity and of cell motility. Proc Natl Acad Sci USA 69: 2456–2459

    Article  PubMed  CAS  Google Scholar 

  • Fisher G, Rice GC, Hahn GM (1986) Dansyl lysine, a new probe for assaying heat-induced cell killing and thermotolerance in vitro and in vivo. Cancer Res 46: 5064–5067

    PubMed  CAS  Google Scholar 

  • Gilman AG (1970) A protein binding assay for adenosine 3’:5’-cyclic monophosphate. Proc Natl Acad Sci USA 67: 305–312

    Article  PubMed  CAS  Google Scholar 

  • Hahn GM, Shiu EC (1985) Protein synthesis, thermotolerance and step down heating. Int J Radiat Oncol Biol Phys 11: 159–164

    Article  PubMed  CAS  Google Scholar 

  • Humphries GMK, Lovejoy JP (1983) Dansyl lysine: a structure-selective fluorescent membrane stain? Biophys J 42: 307–310

    Article  PubMed  CAS  Google Scholar 

  • Landry J, Bernier D, Chretien P, Nicole LM, Tanguay RM, Marceau N (1982) Synthesis and degradation of heat shock proteins during the development and decay of thermotolerance. Cancer Res 42: 2457–2461

    PubMed  CAS  Google Scholar 

  • Li GC (1985) Elevated levels of 70000 dalton heat shock protein in transiently thermotolerant Chinese hamster fibroblasts and in their stable heat resistant variants. Int J Radiat Oncol Biol Phys 11: 165–177

    Article  PubMed  CAS  Google Scholar 

  • Li GC, Mak JY (1985) Induction of heat shock protein synthesis in murine tumors during the development of thermotolerance. Cancer Res 45: 3816–3824

    PubMed  CAS  Google Scholar 

  • Li GC, Peterson NS, Mitchell HK (1982) Induced thermal tolerance and heat shock protein synthesis in Chinese hamster ovary cells. Int J Radiat Oncol Biol Phys 8: 63–67

    PubMed  CAS  Google Scholar 

  • Lieber MM (1984) Technical problems with soft agar colony formation assays for in vitro chemotherapy sensitivity testing of human solid tumours: Mayo Clinic experience. In: Hofmann V, Berens ME, Martz G (eds) Predictive drug testing on human tumor cells. Springer, Berlin Heidelberg New York, pp 51–55 (Recent results in cancer res vol 94)

    Google Scholar 

  • Meyer JL, van Kersen I, Becker B, Hahn GM (1985) The significance of thermotolerance after 41° C hyperthermia: in vivo and in vitro tumor and normal tissue investigations. Int J Radiat Oncol Biol Phys 11: 973–981

    Article  PubMed  CAS  Google Scholar 

  • Meyer JL, van Kersen I, Hahn GM (1986) Tumor responses following multiple hyperthermia and X-ray treatments: role of thermotolerance at the cellular level. Cancer Res 46: 5691–5695

    PubMed  CAS  Google Scholar 

  • Nielsen OS, Overgaard J, Kamura T (1983) Influence of thermotolerance on the interaction between hyperthermia and radiation in a solid tumor in vivo. Br J Radiol 56: 267–273

    Article  PubMed  CAS  Google Scholar 

  • Overgaard J (1985) Rationale and problems in the design of clinical studies. In: Overgaard J (ed) Hyperthermic oncology, vol 2. Taylor and Francis, London, pp 325–328

    Google Scholar 

  • Peterson G (1979) Review of the Folin phenol protein quantitation method of Lowry, Rose-brough, Farr and Randall. Anal Biochem 100: 201–220

    Article  PubMed  CAS  Google Scholar 

  • Puck TT, Marcus PI (1956) The action of X-rays on mammalian cells. J Exp Med 10: 653–669

    Article  Google Scholar 

  • Rice GC, Fisher G, Devlin M, Humphries GMK, Mehdi SQ, Hahn GM (1985) Use of N-X-dansyl-L-lysine and flow cytomtery to identify heat-killed mammalian cells. Int J Hyperthermia 1: 185–191

    Article  PubMed  CAS  Google Scholar 

  • Sciandra JJ, Subjeck JR (1984) Heat shock proteins and protection of proliferation and translation in mammalian cells. Cancer Res 44: 5188–5194

    PubMed  CAS  Google Scholar 

  • Sekiguchi R, Rice GC, Hahn GM (1987) The use of dansyl lysine to assess heat damage of normal tissues. Cancer Res (in press)

    Google Scholar 

  • Stevenson MA, Minton KW, Hahn GM (1981) Survival and Concanavalin-A-induced capping in CHO fibroblasts after exposure to hyperthermia, ethanol and X irradiation. Radiat. Res. 86: 467–478

    Article  PubMed  CAS  Google Scholar 

  • Subjeck JR, Sciandra JJ, Johnson RJ (1982) Heat shock proteins and thermotolerance; a comparison of induction kinetics. Br J Radiol 55: 579–584

    Article  PubMed  CAS  Google Scholar 

  • Urano M, Rice LC, Montoya V (1982) Studies on fractionated hyperthermia in experimental animal systems 2. Response of murine tumors to two or more doses. Int J Radiat Oncol Biol Phys 8: 227–233

    Article  PubMed  CAS  Google Scholar 

  • Welch WJ, Feramisco JR (1985) Rapid purification of mammalian 70000-dalton stress proteins: affinity of the proteins for nucleotides. Mol Cell Biol 5: 1229–1237

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Anderson, R.L., Kapp, D.S., Woo, S.Y., Rice, G.C., Lee, KJ., Hahn, G.M. (1988). Predictive Assays for Tumor Response to Single and Multiple Fractions of Hyperthermia. In: Hinkelbein, W., Bruggmoser, G., Engelhardt, R., Wannenmacher, M. (eds) Preclinical Hyperthermia. Recent Results in Cancer Research, vol 109. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83263-5_26

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-83263-5_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83265-9

  • Online ISBN: 978-3-642-83263-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics