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DNA Vaccination/Genetic Vaccination pp 107–143Cite as

Nucleic Acid-Based Vaccines as an Approach to Immunization Against Human Immunodeficiency Virus Type-1

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 226))

Abstract

The spread of HIV-1 has resulted in significant morbidity and mortality worldwide. Traditional therapeutic approaches have included chemotherapy directed at several different viral components either alone or in combination. Studies evaluating combinations of two or three different anti-retroviral agents have recently generated optimism regarding the ability to control viral replication in vivo. It is too early to tell whether this approach is capable of controlling established infection without additional measures including immunotherapy. In any event, the majority of the worldwide at-risk population will not have easy access to these expensive therapeutic regimens. If achievable, protective vaccination represents the best solution to the worldwide problem of infection with HIV-1 and any strategy designed to control the epidemic is likely to rely heavily on mass immunization campaigns (Musgrove 1993). Unfortunately, the effort to design effective vaccines for HIV-1 has encountered a number of significant obstacles. In a 1993 poll by the journal Science (Cohen 1993) 150 top AIDS researchers agreed that the most significant obstacle has been the lack of consistent correlates of protection from natural or experimental infection. It is therefore not surprising that a wide variety of therapeutic modalities have been proposed in pursuit of effective therapy for HIV-1 (Table 1).

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Authors and Affiliations

  1. Department of Pediatrics, Allegheny University of the Health Sciences, Philadelphia, PA, 19104, USA

    M. L. Bagarazzi, J. D. Boyer, V. Ayyavoo & D. B. Weiner

  2. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    M. L. Bagarazzi, J. D. Boyer, V. Ayyavoo & D. B. Weiner

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  1. M. L. Bagarazzi
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  2. J. D. Boyer
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  3. V. Ayyavoo
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  4. D. B. Weiner
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Editors and Affiliations

  1. Department of Microbiology and Immunology Center for Neurobiology, Thomas Jefferson University, Rm. M-85, Jefferson Alumni Hall 1020 Locust Street, Philadelphia, PA, 19197-6799, USA

    Hilary Koprowski M.D. (Professor) (Professor)

  2. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine Hospital of the University of Pennsylvania, 500 Stellar-Chance Bldg. 422 Curie Boulevard, Philadelphia, PA, 19104-6100, USA

    David B. Weiner Ph.D. (Associate Professor) (Associate Professor)

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© 1998 Springer-Verlag Berlin Heidelberg

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Bagarazzi, M.L., Boyer, J.D., Ayyavoo, V., Weiner, D.B. (1998). Nucleic Acid-Based Vaccines as an Approach to Immunization Against Human Immunodeficiency Virus Type-1. In: Koprowski, H., Weiner, D.B. (eds) DNA Vaccination/Genetic Vaccination. Current Topics in Microbiology and Immunology, vol 226. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80475-5_8

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  • DOI: https://doi.org/10.1007/978-3-642-80475-5_8

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