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Pathogenesis of Experimental Tuberculosis in Animal Models

  • Chapter
Tuberculosis

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 215))

Abstract

Pathogenesis, in the context of an infectious disease, can be defined as the temporal interplay between the microbe and its host which ultimately results in clinical illness. An understanding of pathogenesis requires knowledge of the precise aggressive and/or evasive strategies employed by the microbe and the elucidation of the beneficial and detrimental responses which the host develops upon infection. The kinetics of the host-microbe interaction are at least as important as the isolated activities of either protagonist, since the effectiveness of the strategies and counterstrategies is likely to depend upon the context and environment in which the confrontation occurs. For this reason, the pathogenesis of a disease like tuberculosis will only be revealed by studies of the course of infection in a suitable host.

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Authors and Affiliations

  1. Department of Medical Microbiology and Immunology, Texas A&M University Health Science Center, College Station, TX, 77843, USA

    D. N. McMurray

  2. Mycobacteriology Laboratory, Food and Drug Administration, Bethesda, MD, 20892, USA

    F. M. Collins

  3. Department of Environmental Health Sciences, School of Hygiene and Public Health, The Johns Hopkins University, Baltimore, MD, 21205, USA

    A. M. Dannenberg Jr.

  4. Department of Medical Microbiology and Immunology, University of Wisconsin, Madison, WI, 53706, USA

    D. W. Smith

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  1. D. N. McMurray
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  2. F. M. Collins
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  3. A. M. Dannenberg Jr.
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  4. D. W. Smith
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Editors and Affiliations

  1. Department of Health and Human Services, Immunology and Molecular Pathogenesis Section, Division of AIDS, STD and TB Laboratory Research, Centers for Disease Control and Prevention, 30333, Atlanta, GA, USA

    Thomas M. Shinnick Ph.D. (Chief) (Chief)

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McMurray, D.N., Collins, F.M., Dannenberg, A.M., Smith, D.W. (1996). Pathogenesis of Experimental Tuberculosis in Animal Models. In: Shinnick, T.M. (eds) Tuberculosis. Current Topics in Microbiology and Immunology, vol 215. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80166-2_7

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