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Neurobiology of Simian and Feline Immunodeficiency Virus Infections

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HIV and Dementia

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 202))

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Abstract

The simian and feline immunodeficiency lentivirus infections of captive macaques and domestic cats (SIV and FIV, respectively) are excellent models for HIV infection of humans (Gardner and Luciw 1989). Among the animal lentiviruses, SIV is the most closely related to HIV and both SIV and FIV models manifest a disease pattern and viral encephalopathy with many similarities to that observed in HIV infection of humans (Lackner et al. 1991a; Johnson et al. 1988). As in HIV infection of humans, infection of the CNS with SIV and FIV occurs in virtually all infected individuals, many of whom develop clinical and pathologic evidence of the associated lentivirus encephalopathy.

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Authors and Affiliations

  1. Department of Pathology, School of Medicine, University of California, Davis, CA, 95616, USA

    M. B. Gardner

  2. Department of Internal Medicine, University of California, Davis, CA, 95616, USA

    S. Dandekar

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  1. M. B. Gardner
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  2. S. Dandekar
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Editor information

Editors and Affiliations

  1. Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Michael B. A. Oldstone

  2. Molecular and Cellular Neuroscience Research Branch, Division of Neuroscience and Behavioral Science, National Institutes of Health, National Institute of Mental Health, 5600 Fishers Lane, Rm 11C-06, 20857, Rockville, MD, USA

    Ljubiša Vitković (Chief, Neuroimmunology/Neurovirology Program) (Chief, Neuroimmunology/Neurovirology Program)

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© 1995 Springer-Verlag Berlin Heidelberg

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Gardner, M.B., Dandekar, S. (1995). Neurobiology of Simian and Feline Immunodeficiency Virus Infections. In: Oldstone, M.B.A., Vitković, L. (eds) HIV and Dementia. Current Topics in Microbiology and Immunology, vol 202. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79657-9_10

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  • DOI: https://doi.org/10.1007/978-3-642-79657-9_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79659-3

  • Online ISBN: 978-3-642-79657-9

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