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Human Pathogenic Papillomaviruses pp 199–215Cite as

In Vitro Systems for the Study and Propagation of Human Papillomaviruses

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 186))

Abstract

Papillomaviruses were first shown to be pathogenic agents by Shope and Hurst (1933) who identified them as the causative agent of infectious papillomatosis of cottontail rabbits. Later, Rous and Beard (1935) observed that benign papillomas of rabbits induced by this virus could progress to carcinomas. Attempts to develop systems for the propagation of papillomaviruses in vitro were unsuccessful and resulted in a dormancy of papillomavirus research until the 1970s. The late 1970s brought the beginning of molecular biology technology and the cloning of papillomavirus genomes. This allowed for the isolation of sufficient quantities of material to begin a systematic study of papillomaviruses. In the 1980s a correlation between papillomaviruses and human neoplastic lesions of the anogenital area led to a significant increase in interest in the study of these viruses.

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Authors and Affiliations

  1. Howard Hughes Medical Institute and Department of Molecular Genetics and Cell Biology, The University of Chicago, 920 E 58th Street, Chicago, IL, 60637, USA

    C. Meyers & L. A. Laimins

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  1. C. Meyers
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  2. L. A. Laimins
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  1. Deutsches Krebsforschungszentrum, Vorsitzender des Stiftungsrates, Im Neuenheimer Feld 280, D-69120, Heidelberg, Germany

    Harald zur Hausen

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Meyers, C., Laimins, L.A. (1994). In Vitro Systems for the Study and Propagation of Human Papillomaviruses. In: zur Hausen, H. (eds) Human Pathogenic Papillomaviruses. Current Topics in Microbiology and Immunology, vol 186. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78487-3_11

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  • DOI: https://doi.org/10.1007/978-3-642-78487-3_11

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