Abstract
A considerable amount of recent work in a number of laboratories has led to significant increases in our understanding of the recognition of antigens by T cells. T cells utilize an antigen receptor that is structurally similar to the antigen receptor present on B cells. Despite this apparent similarity, the B cell repertoire enables recognition of a virtually limitless array of foreign antigenic structures, while T cells recognize antigens only when presented in the context of class I or II molecules of the Major Histocompatibility Complex (MHC). One issue which has not been satisfactorily resolved is why and how T cell recognition is focused on MHC antigens. One possibility is that the structures that make up the T cell recognition apparatus are inherently biased toward recognition of MHC molecules. Alternatively, it is possible that TCR molecules that are expressed early during T cell ontogeny in the thymus engender a repertoire similar to that of B cells, but that these receptors are focussed through positive selection mediated by self-MHC antigens. A second issue that also remains unresolved is to what extent the alloantigenic determinants recognized by T cells on foreign class I and class II MHC molecules are dependent upon the presentation of processed host cell proteins.
1This work was supported by National Institutes of Health Grants AI20963, AI21393, AI24815, and American Cancer Society Grant ACS-IM-457. E.Lacy is the recipient of an American Heart Association Established Investigatorship.
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Engelhard, V.H. et al. (1990). Cytotoxic T Cell Responses Against Human Class I Molecules in Normal and HLA-A2.1 Transgenic Mice. In: Egorov, I.K., David, C.S. (eds) Transgenic Mice and Mutants in MHC Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75442-5_25
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