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Human Apolipoprotein A-I and A-II Metabolism

  • Conference paper
Drugs Affecting Lipid Metabolism

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

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Abstract

Recognition of the inverse correlation between high density lipoprotein cholesterol levels and the development of premature cardiovascular disease have focused a great deal of interest on HDL (Miller and Miller 1975; Rhoads et al. 1976; Castelli et al. 1977). HDL has been proposed to function in the process of “reverse cholesterol transport” by facilitating the removal of cholesterol from peripheral cells and transporting it back to the liver where it may be removed from the body (Glomset 1968). In order to gain insight into factors which modulate the plasma levels of HDL, we have systematically analyzed the metabolism of apoA-I and apoA-II, the two major apolipoproteins in HDL. This report will summarize our current studies on apoA-I and apoA-II metabolism.

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Author information

Authors and Affiliations

  1. Metabolism Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, 20892, USA

    L. A. Zech

Authors
  1. H. B. Brewer Jr.
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  2. R. E. Gregg
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  3. S. W. Law
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  4. J. M. Hoeg
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  5. L. A. Zech
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Editor information

Editors and Affiliations

  1. School of Pharmacy, University of Milan, Via Balzaretti 9, 20133, Milan, Italy

    Rodolfo Paoletti (Dean) (Dean)

  2. The Wistar Institute, 3601 Spruce Street, Philadelphia, PA, 19104, USA

    David Kritchevsky (Associate Director) (Associate Director)

  3. 238 Chatham Way, West Chester, PA, 19380, USA

    William L. Holmes

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© 1987 Springer-Verlag Berlin Heidelberg

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Brewer, H.B., Gregg, R.E., Law, S.W., Hoeg, J.M., Zech, L.A. (1987). Human Apolipoprotein A-I and A-II Metabolism. In: Paoletti, R., Kritchevsky, D., Holmes, W.L. (eds) Drugs Affecting Lipid Metabolism. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-71702-4_44

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  • DOI: https://doi.org/10.1007/978-3-642-71702-4_44

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-71704-8

  • Online ISBN: 978-3-642-71702-4

  • eBook Packages: Springer Book Archive

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