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Mouse-Human Hybridomas. The Conversion of Non-Secreting Human B Cells into Ig Secretors

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Lymphocyte Hybridomas

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Abstract

When antibody secreting hybridomas are isolated from immune spleen cell suspensions, which normal cells are the target for hybridization?

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References

  1. Levy, R., and Dilley, J.: Rescue of iimiunoglobulin secretion from human neoplastic lymphoid cells by somatic cell hybridization. Proc. Nat. Acad. Sci. In press (1978)

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  2. Kohler, G. and Milstein, C.: Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495–497 (1975)

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  3. Kohler, G., Howe, S.C. and Milstein, C.: Fusion between imnunoglobulin-secreting and non-secreting myeloma cell lines. Eur. J. Immunol. 6, 231–236 (1977)

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  4. Smith, M., Hirschhorn, K. Schuster, J. and Gold, P.: The study of human immunoglobulins in hybrid cells: tentative assignment of the genes responsible for human heavy chain iitmunoglobulin production to chromosome 2. Third International Workshop on Human Gene Mapping. Baltimore Conf. 1975. Birth defects origial article. Series XII, ed. D. Bergsma (1976)

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  5. Smith, M. and Hirschhorn, K.: Production of human immunoglobulin in heavy and light chains in man-mouse somatic cell hybrids. Fed. Proc. 36, abs #4906, 1196 (1977)

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  6. Weissman, I.L., Warnke, R., Butcher, E.C., Rouse, R. and Levy, R.: The lymphoid system. Its normal architecture and the potential for understanding the system through study of lymphoproliferative diseases. Human Path. 9, 25–45 (1978)

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Authors
  1. R. Levy
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  2. J. Dilley
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  3. K. Sikora
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  4. R. Kucherlapati
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Editor information

Editors and Affiliations

  1. Basel Institute for Immunology, 487 Grenzacherstraße, CH-4005, Basle, Switzerland

    F. Melchers

  2. Division of Cancer Biology and Diagnosis, Laboratory of Cell Biology, National Cancer Institute, Bethesda, MD, 20014, USA

    M. Potter

  3. Dept. of Pathology, University of New Mexico, School of Medicine, Albuquerque, N.M., 87131, USA

    N. L. Warner

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© 1979 Springer-Verlag Berlin Heidelberg

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Levy, R., Dilley, J., Sikora, K., Kucherlapati, R. (1979). Mouse-Human Hybridomas. The Conversion of Non-Secreting Human B Cells into Ig Secretors. In: Melchers, F., Potter, M., Warner, N.L. (eds) Lymphocyte Hybridomas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67448-8_27

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  • DOI: https://doi.org/10.1007/978-3-642-67448-8_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09670-2

  • Online ISBN: 978-3-642-67448-8

  • eBook Packages: Springer Book Archive

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