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Neonatal Pharmacology of Pain

  • Chapter
The Pharmacology of Pain

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 130))

Abstract

It is only a little over a decade since interest arose in the development of pain processing in the mammalian nervous system, and there is now widespread recognition that more basic knowledge is required in this field. Clinical management of paediatric pain has been largely empirical, and there is considerable ignorance about the ability of the infant nervous system to react to painful stimuli and the sensitivity of the developing nervous system to analgesic therapy.

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References

  • Abbot FV, Guy ER (1995) Effects of morphine, pentobarbital and amphetamine on formalin-induced behaviours in infant rats: sedation versus specific suppression of pain. Pain 62:303–312

    Article  Google Scholar 

  • Akagi H, Konishi S, Yanagisawa M, Otsuka M (1983) Effects of capsaicin and a substance P antagonist on a slow reflex in isolated rat spinal cord. Neurochem Res 8:795–796

    Google Scholar 

  • Altman J, Bayer S A (1984) The development of the rat spinal cord. Adv Anat Embryol Cell Biol 85:1–166

    PubMed  CAS  Google Scholar 

  • Attali B, Saya D, Vogel Z (1990) Pre- and postnatal development of opiate receptor subtypes in rat spinal cord. Dev Brain Res 53:97–102

    Article  CAS  Google Scholar 

  • Audinat E, Lambolez B, Rossier J, Crepel F (1994) Activity-dependent regulation of N-methyl-D-aspartate receptor subunit expression in rat cerebellar granule cells. Eur J Neurosci 6:1792–1800

    Article  PubMed  CAS  Google Scholar 

  • Barr GA, Paredes W, Erickson KL, Zukin RS (1986) Kappa-opioid receptor mediated analgesia in the developing rat. Dev Brain Res 29:145–152

    Article  CAS  Google Scholar 

  • Ben-Ari Y, Tseeb V, Raggozzino D, Khazipov R, Gaiarsa JL (1994) Gamma-aminobutyric acid (GABA): a fast excitatory transmitter which may regulate the development of hippocampal neurones in early postnatal life. Prog Brain Res 102:261–73

    Article  PubMed  CAS  Google Scholar 

  • Bennett-Clarke CA, Hankin MH, Leslie MJ, Chiaia NL, Rhoades RW (1994) Patterning of the neocortical projections from the raphe nuclei in perinatal rats: investigation of potential organizational mechanisms. J Comp Neurol 348:277–290

    Article  PubMed  CAS  Google Scholar 

  • Bicknell HR, Beal JA (1984) Axonal and dendritic development of substantia gelatinosa neurons in the lumbosacral spinal cord of the rat. J Comp Neurol 226:508–522

    Article  PubMed  Google Scholar 

  • Blass EM, Cramer CP, Fanselow MS (1993) The development of morphine induced antinociception in neonatal rats: a comparison of forpaw, hindpaw and tail retraction from a thermal stimulus. Pharm Biochem Behav 44:643–649

    Article  CAS  Google Scholar 

  • Bleazard L, Hill RG, Morris R (1994) The correlation between the distribution of the NK1 receptor and the actions of tachykinin agonists in the dorsal horn of the rat indicates that substance P does not have a functional role on substantia gelatinosa (lamina II) neurons. J Neurosci 14:7655–7664

    PubMed  CAS  Google Scholar 

  • Brady RJ, Gorter JA, Monroe MT, Swann JW (1994) Developmental alterations in the sensitivity of hippocampal NMDA receptors to AP5. Dev Brain Res 83:190–196

    Article  CAS  Google Scholar 

  • Bregman BS (1987) Development of serotonin immunoreactivity in the rat spinal cord and its plasticity after neonatal spinal cord lesions. Dev Brain Res 34:245–263

    Article  Google Scholar 

  • Cabalka LM, Ritchie TC, Coulter JD (1990) Immunolocalization of a novel nerve terminal protein in spinal cord development. J Comp Neurol 295:83–91

    Article  PubMed  CAS  Google Scholar 

  • Carmignoto G, Vicini S (1992) Activity dependent decrease in NMDA receptor responses during development of the visual cortex. Science 258:1007–1011

    Article  PubMed  CAS  Google Scholar 

  • Casabona G, Genazzi AA, Di SM, Sortino MA, Nicoletti F (1992) Developmental changes in the modulation of cyclic AMP formation by the metabotropic glutamate receptor agonist 15,3R aminocyclopentane-1,3 dicarboxylicacid in brain slices. J Neurochem 89:1161–1163

    Article  Google Scholar 

  • Catania MV, Landwehrmeyer GB, Testa CM, Standaert DG, Penney JB Jr, Young AB (1994) Metabotropic glutamate receptors are differentially regulated during development. Neurosci 61:481–495

    Article  CAS  Google Scholar 

  • Charlton CG, Heike CJ (1986) Ontogeny of substance-P receptors in the rat spinal cord: quantitative changes in receptor number and differential expression in specific loci. Dev Brain Res 29:81–91

    Article  CAS  Google Scholar 

  • Coggeshall RE, Pover CM, Fitzgerald M (1994) Dorsal root ganglion cell death and surviving cell numbers in relation to the development of sensory innervation in the rat hindlimb. Dev Brain Res 82:193–212

    Article  CAS  Google Scholar 

  • Coggeshall RE, Jennings E, Fitzgerald M (1995) Evidence that large myelinated primary afferent fibres make synaptic contacts in lamina II of neonatal rats. Dev Brain Res 92:81–90

    Article  Google Scholar 

  • Commissiong JW (1983) The development of catecholaminergic nerves in the spinal cord of the rat. II. Regional development. Dev Brain Res 11:75–92

    Article  CAS  Google Scholar 

  • Constantinou J, Reynolds ML, Woolf CJ, Safieh-Garabedian B, Fitzgerald M (1994) Nerve growth factor levels in developing rat skin: upregulation following skin wounding. Neuroreport 5:2281–2284

    Article  PubMed  CAS  Google Scholar 

  • Dickenson AH (1994) Where and how do opioids act? In: Gebhart GF, Hammond DL, Jensen TS (eds) Progress in pain research and management, vol 2. International Association for the Study of Pain, Seattle, pp 525–552

    Google Scholar 

  • Ekholm J (1967) Postnatal changes in cutaneous reflexes and in the discharge pattern of cutaneous and articular sense organs. Acta Physiol Scand [Suppl] 297:1–130

    CAS  Google Scholar 

  • Fanselow MS, Cramer CP (1988) The ontogeny of opiate tolerance and withdrawal in infant rats. Pharmacol Biochem Behav 31:431–438

    Article  PubMed  CAS  Google Scholar 

  • Fitzgerald M (1985) The postnatal development of cutaneous afferent fibre input and receptive field organization in the rat dorsal horn. J Physiol (Lond) 364:1–18

    CAS  Google Scholar 

  • Fitzgerald M (1987) The prenatal growth of fine diameter afferents into the rat spinal cord — a transganglionic study. J Comp Neurol 261:98–104

    Article  PubMed  CAS  Google Scholar 

  • Fitzgerald M (1988) The development of activity evoked by fine diameter cutaneous fibres in the spinal cord of the newborn rat. Neurosci Lett 86:161–166

    Article  PubMed  CAS  Google Scholar 

  • Fitzgerald M (1991a) A physiological study of the prenatal development of cutaneous sensory inputs to dorsal horn cells in the rat. J Physiol (Lond) 432:473–482

    CAS  Google Scholar 

  • Fitzgerald M (1991b) The developmental neurobiology of pain. In: Bond M, Woolf CJ, Charlton M (eds) Proceedings of the 6th World Congress on Pain. Elsevier, Amsterdam, pp 253–261

    Google Scholar 

  • Fitzgerald M (1995) Pain in infancy: some unanswered questions. Pain Rev 2:77–91

    Google Scholar 

  • Fitzgerald M, Anand K (1993) The developmental neuroanatomy and neurophysiology of pain. In: Schechter NL, Berde CB, Yaster Y (eds) Pain in infants, children and adolescents. Williams and Wilkins, Baltimore, pp 11–31

    Google Scholar 

  • Fitzgerald M, Gibson SJ (1984) The postnatal physiological and neurochemical development of peripheral sensory C fibres. Neuroscience 13:933–944

    Article  PubMed  CAS  Google Scholar 

  • Fitzgerald M, Koltzenburg M (1986) The functional development of descending inhibitory pathways in the dorsolateral funiculus of the newborn rat spinal cord. Dev Brain Res 24:261–270

    Article  Google Scholar 

  • Fitzgerald M, Shaw A, Macintosh N (1987) The postnatal development of the cutaneous flexor reflex: a comparative study in premature infants and newborn rat pups. Dev Med Child Neurol 30:520–526

    Article  Google Scholar 

  • Fitzgerald M, Reynolds ML, Benowitz LI (1991) GAP-43 expression in the developing rat lumbar spinal cord. Neurosci 41:187–199

    Article  CAS  Google Scholar 

  • Fitzgerald M, Butcher T, Shortland P (1995) Developmental changes in the laminar termination of A fibre cutaneous sensory afferents in the rat spinal cord dorsal horn. J Comp Neurol 348:225–233

    Article  Google Scholar 

  • Gaiarsa JL, McLean H, Congar P, Leinekugel X, Khazipov R, Tseeb V, Ben-Ari Y (1995a) Postnatal maturation of gamma-aminobutyric acidA and B-mediated inhibition in the CA3 hippocampal region of the rat. J Neurobiol 26:339–349

    Article  CAS  Google Scholar 

  • Gaiarsa JL, Tseeb V, Ben-Ari Y (1995b) Postnatal development of pre- and postsynaptic GABAB-mediated inhibitions in the CA3 hippocampal region of the rat. J Neurophysiol 73:246–255

    CAS  Google Scholar 

  • Gao B-X, Ziskind-Conhaim L (1995) Development of glycine and GABA-gated currents in rat spinal motoneurons. J Neurophysiol 74:113–121

    PubMed  CAS  Google Scholar 

  • Giordano J, Barr GA (1987) Morphine and ketocyclazocine-induced analgesia in the developing rat: differences due to type of noxious stimulus and body topography. Dev Brain Res 32:247–253

    Article  CAS  Google Scholar 

  • Goedert M, Stoeckel K, Otten U (1981) Biological importance of the retrograde axonal transport of nerve growth factor in sensory neurons. Proc Natl Acad Sci USA 78:5895–5898

    Article  PubMed  CAS  Google Scholar 

  • Gonzales R, Coderre TJ, Sherbourne CD, Levine JD (1991) Postnatal development of neurogenic in the rat. Neurosci Lett 127:25–27

    Article  PubMed  CAS  Google Scholar 

  • Gonzalez DL, Fuchs JL, Droge MH (1993) Distribution of NMDA receptor binding in developing mouse spinal cord. Neurosci Lett 151:134–137

    Article  PubMed  CAS  Google Scholar 

  • Guy ER, Abbott FV (1992) The behavioural response to formalin pain in preweanling rats. Pain 51:81–90

    Article  PubMed  CAS  Google Scholar 

  • Hammond DL, Ruda MA (1991) Developmental alterations in nociceptive threshold, immunoreactive calcitonin-gene related peptide, substance P and fluoride resistant acid phosphatase in neonatally capsaicin treated rats. J Comp Neurol 312:436–450

    Article  PubMed  CAS  Google Scholar 

  • Hellendall RP, Schambra UB, Liu JP, Lauder JM (1993) Prenatal expression of 5-HT1C and 5-HT2 receptors in the rat central nervous system. Exp Neurol 120:186–201

    Article  PubMed  CAS  Google Scholar 

  • Hestrin S (1992) Developmental regulation of NMDA receptors-mediated synaptic at a central synapse. Nature 357:686–689

    Article  PubMed  CAS  Google Scholar 

  • Hofer M, Constantine-Paton M (1994) Regulation of N-methyl-D-aspartate (NMDA) receptor function during the rearrangement of developing neuronal connections. Prog Brain Res 102:277–285

    Article  PubMed  CAS  Google Scholar 

  • Hori Y, Kanda K (1994) Developmental alterations in NMDA receptor-mediated [Ca2+]i elevation in substantia gelatinosa neurons of neonatal rat spinal cord. Dev Brain Res 80:141–148

    Article  CAS  Google Scholar 

  • Hori Y, Watanabe S (1987) Morphine-sensitive late components of the flexion reflex in the neonatal rat. Neurosci Lett 78:91–96

    Article  PubMed  CAS  Google Scholar 

  • Hughes HE, Barr GA (1988) Analgesic effects of intrathecally applied noradrenergic compounds in the developing rat: differences due to thermal vs mechanical nociception. Dev Brain Res 41:109–120

    Article  Google Scholar 

  • Hulsebosch CE, Coggeshall RE, Chung K (1986) Numbers of rat dorsal root axons and ganglion cells during postnatal development. Dev Brain Res 26:105–113

    Article  Google Scholar 

  • Izumi Y, Zorumski CF (1994) Developmental changes in the effects of metabotropic glutamate receptor antagonists on CA1 long-term potentiation in rat hippocampal slices. Neurosci Lett 176:89–92

    Article  PubMed  CAS  Google Scholar 

  • Jacowec MW, Fox AJ, Martin CJ, Kalb RG (1995a) Quantitative and qualitative changes in AMPA receptor expression during spinal cord development. Neuroscience 67:893–907

    Article  Google Scholar 

  • Jacowec MW, Yen L, Kalb RG (1995b) In situ hybridization analysis of AMPA receptor subunit gene expression in the developing rat spinal cord. Neuroscience 67:909–920

    Article  Google Scholar 

  • Jennings E, Fitzgerald M (1996) C-fos can be induced in the neonatal rat spinal cord by both noxious and innocuous stimulation. Pain 68:301–30

    Article  PubMed  CAS  Google Scholar 

  • Kar S, Quirion R (1995) Neuropeptide receptors in developing and adult rat spinal cord: an in vitro quantitative autoradiography study of calcitonin gene-related peptide, neurokinins, μ-opioid, galanin, somatostatin, neurotensin and vasoactive intestinal polypeptide receptors. J Comp Neurol 354:253–281

    Article  PubMed  CAS  Google Scholar 

  • King AE, Lopez-Garcia JA (1993) Excitatory amino acid receptor mediated neurotransmission from cutaneous afferents in rat dorsal horn “in vitro”. J Physiol (Lond) 472:443–457

    CAS  Google Scholar 

  • Lewin GR, Ritter AM, Mendell LM (1993) Nerve growth factor-induced hyperalgesia in the neonatal and adult rat. J Neurosci 13:2136–2148

    PubMed  CAS  Google Scholar 

  • Lucas JJ, Hen R (1995) New players in the 5-HT receptor field: genes and knockouts. Trends Pharmocol Sci 16:217–252

    Article  Google Scholar 

  • Ma W, Behar T, Chang L, Barker JL (1994) Transient increase in expression of GAD65 and GAD67 mRNAs during postnatal development of rat spinal cord. J Comp Neurol 346:151–160

    Article  PubMed  CAS  Google Scholar 

  • Marti E, Gibson SJ, Polak JM, Facer P, Springall DR, Van Aswegen G, Aitchison M, Koltzenburg M (1987) Ontogeny of peptide and amine-containing neurones in motor, sensory, and autonomic regions of rat and human spinal cord, dorsal root ganglia, and rat skin. J Comp Neurol 266:332–359

    Article  PubMed  CAS  Google Scholar 

  • McLaughlin CR, Litchman AH, Fanselow MS, Cramer CP (1990) Tonic nociception in neonatal rats. Pharmacol Biochem Behav 36:859–862

    Article  PubMed  CAS  Google Scholar 

  • Mendelson B (1994) Chronic embryonic MK-801 exposure disrupts the somatotopic organization of cutaneous nerve projections in the chick spinal cord Dev Brain Res 82:152–166

    Article  CAS  Google Scholar 

  • Morrisett RA, Mott DD, Lewis DV, Wilson WA, Swartzwelder HS (1990) Reduced sensitivity of the N-methyl-D-aspartate component of synaptic transmission to magnesium in hippocampal slices from immature rats. Dev Brain Res 56:257–262

    Article  CAS  Google Scholar 

  • Murphey LJ, Olsen GD (1995) Developmental change of mu receptors in neonatal guinea pig brain stem. Dev Brain Res 85:146–148

    Article  CAS  Google Scholar 

  • Nagy I, Miller BA, Woolf CJ (1994) NK1 and NK2 receptors contribute to C-fibre evoked slow potentials in the rat spinal cord. Neuroreport 5:2105–2108

    Article  PubMed  CAS  Google Scholar 

  • Nicoletti F, Iadotola MJ, Wroblewski JT, Costa E (1986) Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with α 1-adrenoreceptors. Proc Natl Acad Sci USA 83:1931–1935

    Article  PubMed  CAS  Google Scholar 

  • Oka T, Liu X-F, Kajita T, Ohgiya N, Ghoda K, Taniguchi T, Arai Y, Matsumiya T (1992) Effects of subcutaneous administration of enkephalins on tail-flick response and righting reflex of developing rats. Dev Brain Res 69:271–276

    Article  CAS  Google Scholar 

  • Pignatelli D, Ribeiro-da-Silva A, Coimbra A (1989) Postnatal maturation of primary afferent terminations in the substantia gelatinosa of the rat spinal cord. An electron microscope study. Brain Res 491:33–44

    Article  PubMed  CAS  Google Scholar 

  • Pranzatelli MR (1993) Regional differences in the ontogeny of 5-hydroxytryptamine-1C binding sites in rat brain and spinal cord. Neurosci Lett 149:9–11

    Article  PubMed  CAS  Google Scholar 

  • Pranzatelli MR, Galvan I (1994) Ontogeny of [125I]iodocyanopindolol-labelled 5-hydroxytryptamine1B-binding sites in the rat CNS. Neurosci Lett 167:166–170

    Article  PubMed  CAS  Google Scholar 

  • Rajaofetra N, Poulat P, Marlier L, Geffard M, Privat A (1992) Pre- and postnatal development of noradrenergic projections to the rat spinal cord: an immunocytochemical study. Dev Brain Res 67:237–246

    Article  CAS  Google Scholar 

  • Reichling DB, Kyrozis A, Wang J, McDermott AB (1994) Mechanisms of GABA and glycine depolarization-induced calcium transients in rat dorsal horn neurons. J Physiol (Lond) 476:411–421

    CAS  Google Scholar 

  • Reynolds ML, Fitzgerald M (1992) Neonatal sciatic nerve section results in TMP but not SP or CGRP depletion from the terminal field in the dorsal horn of the rat: the role of collateral sprouting. Neuroscience 51:191–202

    Article  PubMed  CAS  Google Scholar 

  • Rhoades RW, Bennett-Clarke CA, Shi MY, Mooney RD (1994) Effects of 5-HT on thalamocortical synaptic transmission in the developing rat. J Neurophysiol 72:2438–2450

    PubMed  CAS  Google Scholar 

  • Riva MA, Tascedda F, Molteni R, Racagni G (1994) Regulation of NMDA receptor subunit mRNA expression in the rat brain during postnatal development. Mol Brain Res 25:209–216

    Article  PubMed  CAS  Google Scholar 

  • Schaffner AE, Behar T, Nadi S, Barker JL (1993) Quantitative analysis of transient GABA expression in embryonic and early postnatal rat spinal neurons. Dev Brain Res 72:265–276

    Article  CAS  Google Scholar 

  • Senba E, Hiosaka S, Hara Y, Inagaki S, Sakanaka M, Takatsuki K, Kawai Y, Tohyama M (1982) Ontogeny of the peptidergic system in the rat spinal cord. Immunohistochemical analysis. J Comp Neurol 208:54–66

    Article  PubMed  CAS  Google Scholar 

  • Shortland P, Molander C, Fitzgerald M, Woolf CJ (1990) Neonatal capsaicin treatment induces invasion of the substantia gelatinosa by the arborizations of hair follicle afferents in the rat dorsal horn. J Comp Neurol 296:23–31

    Article  PubMed  CAS  Google Scholar 

  • Sivilotti LG, Gerber G, Rawat B, Woolf CJ (1995) Morphine selectively depresses the slowest, NMDA-dependent component of C-fibre evoked synaptic activity in the rat spinal cord “in vitro”. Eur J Neurosci 7:12–18

    Article  PubMed  CAS  Google Scholar 

  • Somogyi R, Wen X, Ma W, Barker JL (1995) Developmental kinetics of GAD family mRNAs parallel neurogenesis in the rat spinal cord. J Neurosci 15:2575–2591

    PubMed  CAS  Google Scholar 

  • Soyguder Z, Schmidt HHHW, Morris R (1994) Postnatal development of nitric oxide synthase type I expression in the lumbar spinal cord of the rat: a comparison of c-fos in response to peripheral application of mustard oil. Neurosci Lett 180:188–192

    Article  PubMed  CAS  Google Scholar 

  • Strata F, Cherubini E (1994) Transient expression of a novel type of GABA response in rat CA3 hippocampal neurones during development. J Physiol (Lond) 480:493–503

    CAS  Google Scholar 

  • Suzue T, Jessell T (1980) Opiate analgesics and endorphins inhibit rat dorsal root potential in vitro. Neurosci Lett 16:161–166

    Article  PubMed  CAS  Google Scholar 

  • Thompson SWN, King AE, Woolf CJ (1990) Activity dependent changes in rat ventral horn neurons “in vitro”, summation of prolonged afferent evoked postsynaptic depolarizations produce a D-2-amino-5-phosphonovaleric acid sensitive wind-up. Eur J Neurosci 2:638–649

    Article  PubMed  CAS  Google Scholar 

  • Thompson SWN, Gerber G, Sivilotti LG, Woolf CJ (1992) Long duration ventral root potentials in the neonatal rat spinal cord “in vitro”, the effects of ionotropic and metabotropic excitatory amino acid receptor antagonists. Brain Res 595:87–97

    Article  PubMed  CAS  Google Scholar 

  • Tribollet E, Goumaz M, Raggenbass M, Dubois-Dauphin M, Dreifuss JJ (1991) Early appearance and transient expression of vasopressin receptors in the brain of rat fetus and infant. An autoradiographical and electrophysiological study. Dev Brain Res 58:13–24

    Article  CAS  Google Scholar 

  • Van Praag H, Frenk H (1991) The development of stimulation-produced analgesia (SPA) in the rat. Dev Brain Res 64:71–76

    Article  Google Scholar 

  • Van Praag H, Frenk H (1992) The effects of systemic morphine on behaviour and EEG in newborn rats. Dev Brain Res 67:19–26

    Article  Google Scholar 

  • Wang J, Reichling DB, Kyrozis A, MacDermott AB (1994) Developmental loss of GABA- and glycine-induced depolarization and Ca2+ transients in embryonic rat dorsal horn neurons in culture. Eur J Neurosci 6:1275–1280

    Article  PubMed  CAS  Google Scholar 

  • Wang SD, Goldberger ME, Murray M (1991) Normal development and the effects of early rhizotomy on spinal systems in the rat. Dev Brain Res 64:57–69

    Article  CAS  Google Scholar 

  • Watanabe M, Mishina M Inoue Y (1994) Distinct spatiotemporal distributions of the N-methyl-D-aspartate receptor channel subunit mRNAs in the mouse cervical cord. J Comp Neurol 345:314–319

    Article  PubMed  CAS  Google Scholar 

  • Williams S, Evan G, Hunt SP (1990) Changing patterns of c-fos induction in spinal neurons following thermal cutaneous stimulation in the rat. Neuroscience 49: 3673–3681

    Google Scholar 

  • Woolf CJ, King AE (1987) Physiology and morphology of multireceptive neurons with C afferent fiber inputs in the deep dorsal horn of the rat lumbar spinal cord. J Neurophysiol 58:460–479

    PubMed  CAS  Google Scholar 

  • Young MR, Fleetwood-Walker SM, Mitchell R, Munroe FE (1994) Evidence for a role of metabotropic glutamate receptors in sustained nociceptive inputs to rat dorsal horn neurons. Neuropharmacology 33:141–144

    Article  PubMed  CAS  Google Scholar 

  • Zhang AZ, Pasternak GW (1981) Ontogeny of opioid pharmacology and receptors: high and low affinity site differences. Eur J Pharmacol 73:29–40

    Article  PubMed  CAS  Google Scholar 

  • Zhong J, Carrozza DP, Williams K, Pritchett DB, Molinoff PB (1995) Expression of mRNAs encoding subunits of the NMDA receptor in developing rat brain. J Neurochem 64:531–539

    Article  PubMed  CAS  Google Scholar 

  • Ziskind-Conhaim L, Seebach BS, Gao BX (1993) Changes in serotonin-induced potentials during spinal cord development. J Neurophysiol 69:1338–1349

    PubMed  CAS  Google Scholar 

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  1. M. Fitzgerald
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Editors and Affiliations

  1. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK

    A. Dickenson

  2. Physiopharmacologie du Système Nerveux et Laboratioire de Physiopharmacologie de la Douluer (EPHE), INSERM, U.161, 2, rue d’Alésia, F-75014, Paris, France

    J.-M. Besson

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Fitzgerald, M. (1997). Neonatal Pharmacology of Pain. In: Dickenson, A., Besson, JM. (eds) The Pharmacology of Pain. Handbook of Experimental Pharmacology, vol 130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60777-6_16

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  • DOI: https://doi.org/10.1007/978-3-642-60777-6_16

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