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Inhibitory Neurotransmitters and Nociception: Role of GABA and Glycine

  • Chapter
The Pharmacology of Pain

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 130))

Abstract

As the two most important inhibitory amino acid neurotransmitters in the central nervous system, γ-aminobutyric acid (GABA) and glycine play important roles in the processing of nociceptive information. At present three receptors for GABA receptors are recognized — GABAA, GABAB, and GABAC — and two for glycine — GlyA and GlyB. This chapter reviews briefly the pharmacology, anatomy, and molecular biology of these two neurotransmitters and their receptors and then examine their roles in acute and persistent nociception.

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Authors
  1. D. L. Hammond
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Editors and Affiliations

  1. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK

    A. Dickenson

  2. Physiopharmacologie du Système Nerveux et Laboratioire de Physiopharmacologie de la Douluer (EPHE), INSERM, U.161, 2, rue d’Alésia, F-75014, Paris, France

    J.-M. Besson

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© 1997 Springer-Verlag Berlin Heidelberg

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Hammond, D.L. (1997). Inhibitory Neurotransmitters and Nociception: Role of GABA and Glycine. In: Dickenson, A., Besson, JM. (eds) The Pharmacology of Pain. Handbook of Experimental Pharmacology, vol 130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60777-6_14

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  • DOI: https://doi.org/10.1007/978-3-642-60777-6_14

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  • Print ISBN: 978-3-642-64550-1

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