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Immunogenetics of Reproduction:An Overview

  • Chapter
Reproductive Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 222))

Abstract

The survival of allografts in mammals is influenced by genes of the major histocompatibility complex(MHC); in humans incompatibility with respect to HLA genes is associated with rapid rejection of foreign tissues(VAN ROOD and CLAAS 1990; RATNER et al. 1991). A notable exception is pregnancy, during which allogeneic(fetal) tissues escape rejection. The immunologically privileged nature of the fetal allograft was first noted by MEDAWAR in 1953, and maternal tolerance of an allogeneic fetus is a paradox that remains a central theme in reproductive immunological research today.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, MC2050, University of Chicago, 5841 Maryland Avenue, Chicago, IL, 60637, USA

    C. Ober

  2. Department of Obstetrics and Gynecology, University of Bonn, Sigmund Freud Str. 25, 53105, Bonn-Venusberg, Germany

    K. van der Ven

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  1. C. Ober
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  2. K. van der Ven
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Editors and Affiliations

  1. Department of Immunology, Microbiology, Pathology and Infectious Diseases Karolinska Institute Division of Pathology, F42 Huddinge University Hospital, Huddinge, S-141 86, Sweden

    Lars B. Olding M.D., Ph.D.

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© 1997 Springer-Verlag Berlin Heidelberg

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Ober, C., van der Ven, K. (1997). Immunogenetics of Reproduction:An Overview. In: Olding, L.B. (eds) Reproductive Immunology. Current Topics in Microbiology and Immunology, vol 222. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60614-4_1

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  • DOI: https://doi.org/10.1007/978-3-642-60614-4_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64475-7

  • Online ISBN: 978-3-642-60614-4

  • eBook Packages: Springer Book Archive

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