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Mechanisms for Posttranscriptional Regulation by Iron-Responsive Elements and Iron Regulatory Proteins

  • Chapter
Cytoplasmic fate of messenger RNA

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 18))

Abstract

Iron deficiency is a wide-spread nutritional problem amongst the world’s population. Often the symptoms like pallor, fatigue, and anemia yield to treatment with iron, but irreversible harmful effects of iron deficiency in the development of children have also been observed. On the other extreme, primary or secondary iron overload can lead to hemochromatosis or hemosiderosis, which are characterized by iron deposits and multiorgan pathology including liver cirrhosis, cardiac dysfunction, and arthritis.

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  1. Gene Expression Programme, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117, Heidelberg, Germany

    M. Muckenthaler & M. W. Hentze

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  1. M. Muckenthaler
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  1. Institut de Génétique Moléculaire, C.N.R.S., 1919 route de Mende, B.P. 5051, 34033, Montpellier Cedex 01, France

    Philippe Jeanteur

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Muckenthaler, M., Hentze, M.W. (1997). Mechanisms for Posttranscriptional Regulation by Iron-Responsive Elements and Iron Regulatory Proteins. In: Jeanteur, P. (eds) Cytoplasmic fate of messenger RNA. Progress in Molecular and Subcellular Biology, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60471-3_5

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