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Genetic Regulation of Nicotine-Related Behaviors and Brain Nicotinic Receptors

  • Chapter
Neuronal Nicotinic Receptors

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 144))

Abstract

Nicotinic cholinergic receptor (nAChR) subunit mRNAs are found throughout the brain which suggests that nAChRs may have a widespread influence on brain function and explains why the administration of nicotine to humans or laboratory animals results in a multiplicity of behavioral effects. A minimum of seven different nAChR α subunits and three different nAChR β subunits are expressed in the mammalian brain which could lead to extensive diversity in the types of receptors that are actually produced. Enormous progress has been made in the last few years in identifying the receptor types that are expressed in the mammalian brain, but minimal progress has been made in identifying which behaviors (normal, abnormal, and drug-induced) are modulated by specified receptor subtypes. Our goals are to summarize and critically comment on data showing that genetic strategies have been useful in providing answers to questions related to the function and regulation of brain nAChRs.

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  1. J. A. Stitzel
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  2. S. S. Leonard
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  1. Università degli Studi di Milano Dipartimento di Farmacologia, Chemoterapia e Tossicologia Medica “Emilio Trabucchi”, Via Vanvitelli, 32, 20129, Milano, Italy

    Francesco Clementi , Diego Fornasari  & Cecilia Gotti ,  & 

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© 2000 Springer-Verlag Berlin Heidelberg

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Stitzel, J.A., Leonard, S.S., Collins, A.C. (2000). Genetic Regulation of Nicotine-Related Behaviors and Brain Nicotinic Receptors. In: Clementi, F., Fornasari, D., Gotti, C. (eds) Neuronal Nicotinic Receptors. Handbook of Experimental Pharmacology, vol 144. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57079-7_22

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  • DOI: https://doi.org/10.1007/978-3-642-57079-7_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63027-9

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