Summary
Measurements of axonal diameters in regenerating facial nerves of rats indicated a loss of axonal volume of approximately 60% in 14 days. These measurements were made in the intramedullary genu of the facial nerve thus indicating that transection of the distal portion of the nerve produces marked changes throughout the length of the injured axons.
Experimental studies on the transport of radioactive proteins in hypoglossal nerves of guinea pigs showed a significant increase of the radioactive material transported into the regenerating nerves, assumed to be mainly the fast component.
The slowly moving component of axonal flow appeared to be affected as well. Preliminary data suggest a redistribution rather than a change in the rate of transport in regenerating axons.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Droz, B., Leblond, C. P.: Axonal migration of proteins in the central nervous system and peripheral nerves as shown by autoradiography. J. comp. Neurol. 121, 325–345 (1963).
Grafstein, B.: Role of axonal transport in nerve regeneration. Acta Neuropath. (Berl.) Suppl. V, 144–152 (1971).
— Murray, M.: Transport of protein in gold fish optic nerve during regeneration. Exp. Neurol. 25, 494–508 (1969).
Karlsson, J. O., Sjöstrand, J.: Transport of labelled proteins in the optic nerve and tract of the rabbit. Brain Res. 11, 431–439 (1968).
Kreutzberg, G. W.: Autoradiographic study on incorporation of leucine-H3 in peripheral nerves during regeneration. Experientia (Basel) 23, 33 (1967).
— Schubert, P.: Volume changes in the axon during regeneration. Acta neuropath. (Berl.) 17, 220–226 (1971).
Lasek, R. J.: Axoplasmic transport in cat dorsal root ganglion cells as studied with 3H-leucine. Brain Res. 7, 360–377 (1968).
Lubińska, L.: Axoplamic streaming in regenerating and in normal nerve fibers. Progr. Brain Res. 13, 1–66 (1964).
McEwen, B. S., Grafstein, B.: Fast and slow components in axonal transport of protein. J. Cell Biol. 38, 494–509 (1968).
Miani, N.: Analysis of the somato-axonal movement of phospholipids in the vagus and hypoglossal nerves. J. Neurochem. 10, 859–874 (1963).
Ochs, S., Johnson, J., Ng, M. H.: Protein incorporation and axoplasmic flow in motoneuron fibres following intracord injection of labelled leucine. J. Neurochem. 14, 317–331 (1967).
Taylor, A. C., Weiss, P.: Demonstration of axonal flow by the movement of tritium-labelled protein in mature optic nerve fibers. Proc. nat. Acad. Sci. (Wash.) 54, 1521–1527 (1965).
Weiss, P., Hiscoe, H. B.: Experiments on the mechanism of nerve growth. J. exp. Zool. 107, 315–395 (1948).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1971 Springer-Verlag
About this paper
Cite this paper
Kreutzberg, G.W., Schubert, P. (1971). Changes in Axonal Flow during Regeneration of Mammalian Motor Nerves. In: Friede, R.L., Seitelberger, F. (eds) Symposium on Pathology of Axons and Axonal Flow. Acta Neuropathologica / Supplementum, vol 5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-47449-1_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-47449-1_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-05433-7
Online ISBN: 978-3-642-47449-1
eBook Packages: Springer Book Archive