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Flavones from the Root of Scutellaria baicalensis Georgi – Drugs of the Future in Neurodegeneration and Neuroprotection?

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Systems Biology of Free Radicals and Antioxidants

Abstract

Flavonoids are natural, plant-derived compounds which exert diverse biological activities and also valuable neuroprotective actions within the brain and currently are intensively studied as agents able to modulate neuronal function and to prevent age-related neurodegeneration. Among them, flavones isolated from Scutellaria baicalensis root exhibit strong neuroprotective effects on the brain and are not toxic in the broad range of tested doses. Their neuroprotective potential has been shown in both oxidative stress-induced and amyloid-β- and α-synuclein-induced neuronal death models. Baicalein, the main flavone present in Scutellaria baicalensis root, strongly inhibited aggregation of neuronal amyloidogenic proteins in vitro and induces dissolution of amyloid deposits. It exerts strong antioxidative and anti-inflammatory activities and also exhibits anticonvulsive, anxiolytic, and mild sedative actions. Importantly, baicalein and also another flavone, oroxylin A, markedly enhanced cognitive and amnestic functions in animal models of aging brains and neurodegeneration. In the preliminary study, wogonin, another flavone from Scutellaria baicalensis root, has been shown to stimulate brain tissue regeneration, inducing differentiation of neuronal precursor cells. This chapter provides the main examples of neuroprotective activities of the flavones and reveals their potential in prevention and therapy of neurodegenerative diseases.

Main part of this chapter was originally published in Gasiorowski et al., 2011. Published with kind permission of © Bentham Science Publishers 2011. All Rights reserved.

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Abbreviations

AD:

Alzheimer's disease

COX:

Cyclooxygenase

IL:

Interleukin

iNOS:

Inducible nitric oxide synthase

GABA:

Gamma-aminobutyric acid

NFKB:

Nuclear factor-kappaB

NO:

Nitric oxide

PD:

Parkinson’s disease

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Acknowledgments

This study was partially supported by the “GALLY” International Biomedical Research Consulting LLC., San Antonio, Texas, USA. We are very grateful to Ms. Galina Alieva for her editorial works.

Conflict of interest

Authors declared no conflict of the interest.

Disclosure

Part of information included in this chapter has been previously published (Gasiorowski K, Lamer-Zarawska E, Leszek J, Parvathaneni K, Yendluri BB, Błach-Olszewska Z, Aliev G (2011) Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? CNS Neurol Disord Drug Targets 10(2):184–191). Reprinted with permission of CNS Neurol Disord Drug Targets 2011;10(2):184–91 (Gasiorowski K, Lamer-Zarawska E, Leszek J, Parvathaneni K, Yendluri BB, Błach-Olszewska Z, Aliev G (2011) Flavones from root of Scutellaria baicalensis Georgi: drugs of the future in neurodegeneration? CNS Neurol Disord Drug Targets. 10(2):184–191).

The purpose of this chapter is to outline areas of research potentially implication of the flavones from the root of Scutellaria baicalensis Georgi as new and emerging strategies for the development of the new drugs against neurodegeneration which is chronic and, largely, incurable disease.

Author information

Authors and Affiliations

  1. GALLY International Biomedical Research Consulting LLC, 7733 Louis Pasteur Drive, #328, San Antonio, TX, 78229, USA

    Gjumrakch Aliev

  2. School of Health Science and Healthcare Administration, University of Atlanta, Atlanta, GA, 30097, USA

    Gjumrakch Aliev

  3. Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russian Federation

    Yury G. Kaminsky & Elena A. Kosenko

  4. Stress Relief and Memory Training Center, 3101 Ocean Pkwy #1a Brooklyn, New York, 11235, USA

    Valentin Bragin

  5. Institute of Physiologically Active Compounds. Russian Academy of Sciences, 1st Severniy Proezd, Chernogolovka, Moscow Region, 142432, Russian Federation

    Sergey G. Klochkov & Sergey O. Bachurin

  6. Medical Center of the Administration of the President of the Republic of Kazakhstan, Street Orunbor 2, “House of Ministry” 18, Astana, 010000, Kazakhstan

    Valery V. Benberin

Authors
  1. Gjumrakch Aliev
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  2. Yury G. Kaminsky
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  3. Valentin Bragin
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  4. Elena A. Kosenko
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  5. Sergey G. Klochkov
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  6. Sergey O. Bachurin
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  7. Valery V. Benberin
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Corresponding author

Correspondence to Gjumrakch Aliev .

Editor information

Editors and Affiliations

  1. Department of Pharmacology and Therapeutics, University of British Colombia, Vancouver, British Columbia, Canada

    Ismail Laher

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© 2011 Bentham Science Publishers

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Aliev, G. et al. (2011). Flavones from the Root of Scutellaria baicalensis Georgi – Drugs of the Future in Neurodegeneration and Neuroprotection?. In: Laher, I. (eds) Systems Biology of Free Radicals and Antioxidants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-30018-9_207

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