Abstract
Center-surround antagonistic receptive field in the retina is generated by negative feedback from horizontal cells (HCs) via a proton feedback mechanism [1]. In this study, the contribution of protons on the color opponent signal formation is analyzed. Increasing the buffer capacity of the external medium by 10 mM HEPES depolarized the dark membrane potential of HCs, and substantially increased hyperpolarizing responses to light stimulation. In contrast, feedback mediated depolarizing responses of H2 and H3 HCs were suppressed by HEPES. Moreover, depolarizing response onset of H2 and H3 HCs was significantly delayed compared to the hyperpolarizing responses. These indicate that proton plays an important role on the color opponent signal formation of HCs, and that the feedback from H1 to H2 HCS is delayed by 10 – 20 ms. A similar delay might be applicable to other feedback pathways as well.
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References
Hirasawa, H., Kaneko, A.: pH Changes in the Invaginating Synaptic Cleft Mediate Feedback from Horizontal Cells to Cone Photoreceptors by Modulating Ca2 + 2+ Channels. J. Gen. Physiol. 122, 657–671 (2003)
Kaneko, A., Yamada, M.: S-Potentials in the Dark-Adapted Retina of the Carp. J. Physiol. 227, 261–273 (1972)
Tsukamoto, Y., Yamada, M., Kaneko, A.: Morphological and Physiological Studies of Rod-Driven Horizontal Cells with Special Reference to the Question of whether They Have Axons and Axon Terminals. J. Comp. Neurol. 255, 305–316 (1987)
Stell, W.K., Lightfoot, D.O., Wheeler, T.G., Leeper, H.F.: Goldfish Retina: Functional Polarization of Cone Horizontal Cell Dendrites and Synapses. Science 190, 989–990 (1975)
Perlman, I., Normann, R.A.: The Effects of GABA and Related Drugs on Horizontal Cells in the Isolated Turtle Eetina. Vis. Neurosci. 5, 469–477 (1990)
Barnes, S., Bui, Q.: Modulation of Calcium-Activated Chloride Current via pH-Induced Changes of Calcium Channel Properties in Cone Photoreceptors. J. Neurosci. 11, 4015–4023 (1991)
Tombaugh, G.C., Somjen, G.G.: Effects of Extracellular pH on Voltage-Gated Na + +, K + + and Ca2 + 2+ Currents in Isolated rat CA1 Neurons. J. Physiol. 493, 719–732 (1996)
Cadetti, L., Thoreson, W.B.: Feedback Effects of Horizontal Cell Membrane Potential on Cone Calcium Currents Studied with Simultaneous Recordings. J. Neurophysiol. 95, 1992–1995 (2006)
Vessey, J.P., Stratis, A.K., Daniels, B.A., Da Silva, N., Jonz, M.G., Lalonde, M.R., Baldridge, W.H., Barnes, S.: Proton-Mediated Feedback Inhibition of Presynaptic Calcium Channels at the Cone Photoreceptor Synapse. J. Neurosci. 25, 4108–4117 (2005)
Jouhou, H., Yamamoto, K., Homma, A., Hara, M., Kaneko, A., Yamada, M.: Depolarization of Isolated Horizontal Cells of Fish Acidifies their Immediate Surrounding by Activating V-ATPase. J. Physiol. 585, 401–412 (2007)
Yamamoto, K., Jouhou, H., Iwasaki, M., Kaneko, A., Yamada, M.: Strongly pH-Buffered Ringer’s Solution Expands the Receptive Field Size of Horizontal Cells in the Carp Retina. Zoolog. Sci. 25, 419–427 (2008)
Harosi, F.I.: Spectral Relations of Cone Pigments in Goldfish. J. Gen. Physiol. 68, 65–80 (1976)
Yang, X.L., Tauchi, M., Kaneko, A.: Convergence of Signals from Red-Sensitive and Green-Sensitive Cones onto L-Type External Horizontal Cells of the Goldfish Retina. Vision Res. 23, 371–380 (1983)
Yasui, S., Yamada, M.: H1 Horizontal Cells of Carp Retina have Different Postsynaptic Mechanisms to Mediate Short- versus Long-Wavelength Visual Signals. Exp. Brain Res. 74, 156–162 (1989)
Hare, W.A., Owen, W.G.: Effects of Bicarbonate versus HEPES Buffering on Measured Properties of Neurons in the Salamander Retina. Vis. Neurosci. 15, 263–271 (1998)
DeVries, S.H.: Exocytosed Protons Feedback to Suppress the Ca2 + Current in Mammalian Cone Photoreceptors. Neuron. 32, 1107–1117 (2001)
Hosoi, N., Arai, I., Tachibana, M.: Group III Metabotropic Glutamate Receptors and Exocytosed Protons Inhibit L-Type Calcium Currents in Cones but not in Rods. J. Neurosci. 25, 1062–1072 (2005)
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Kamiji, N.L., Yamada, M., Yamamoto, K., Hirasawa, H., Kurokawa, M., Usui, S. (2011). Analysis of the Proton Mediated Feedback Signals in the Outer Plexiform Layer of Goldfish Retina. In: Lu, BL., Zhang, L., Kwok, J. (eds) Neural Information Processing. ICONIP 2011. Lecture Notes in Computer Science, vol 7064. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-24965-5_77
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DOI: https://doi.org/10.1007/978-3-642-24965-5_77
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