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Organometallic Radiopharmaceuticals

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Medicinal Organometallic Chemistry

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 32))

Abstract

Although molecular imaging agents have to be synthesized ultimately from aqueous solutions, organometallic complexes are becoming more and more important as flexible yet kinetically stable building blocks for radiopharmaceutical drug discovery. The diversity of ligands, targets, and targeting molecules related to these complexes is an essential base for finding novel, noninvasive imaging agents to diagnose and eventually treat widespread diseases such as cancer. This review article covers the most important findings toward these objectives accomplished during the past 3–4 years. The two major available organometallic building blocks will be discussed in the beginning together with constraints for market introduction as imposed by science and industry. Since targeting radiopharmaceuticals are a major focus of current research in molecular imaging, attempts toward so-called technetium essential radiopharmaceuticals will be briefly touched in the beginning followed by the main discussion about the labeling of targeting molecules such as folic acid, nucleosides, vitamins, carbohydrates, and fatty acids. At the end, some new strategies for drug discovery will be introduced together with results from organometallic chemistry in water. The majority of the new results have been achieved with the [99mTc(OH2)3(CO)3]+ complex which will, though not exclusively, be a focus of this review.

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References

  1. Jaouen G (2001) Chem Br 37:36–38

    Google Scholar 

  2. Dyson PJ, Sava G (2006) Dalton Trans 1929–1933

    Google Scholar 

  3. Yan YK, Melchart M, Habtemariam A, Sadler PJ (2005) Chem Commun 4764–4776

    Google Scholar 

  4. Schatzschneider U, Metzler-Nolte N (2006) Angew Chem Int Ed 45:1504–1507

    CAS  Google Scholar 

  5. van Staveren DR, Bothe E, Weyhermuller T, Metzler-Nolte N (2002) Eur J Inorg Chem 6:1518–1529

    Google Scholar 

  6. Gloaguen F, Lawrence JD, Rauchfuss TB, Benard M, Rohmer MM (2002) Inorg Chem 41:6573–6582

    CAS  Google Scholar 

  7. Kayal A, Rauchfuss TB (2003) Inorg Chem 42:5046–5048

    CAS  Google Scholar 

  8. Metzler-Nolte N (2006) In: Jaouen G (ed) Bioorganometallics. Wiley-VCH, Weinheim, pp 125–179

    Google Scholar 

  9. Melchart M, Sadler PJ (2006) In: Jaouen G (ed) Bioorganometallics. Wiley-VCH, Weinheim, pp 39–64

    Google Scholar 

  10. Serli B, Zangrando E, Gianferrara T, Scolaro C, Dyson PJ, Bergamo A, Alessio E (2005) Eur J Inorg Chem 17:3423–3434

    Google Scholar 

  11. Aird RE, Cummings J, Ritchie AA, Muir M, Morris RE, Chen H, Sadler PJ, Jodrell DI (2002) Br J Cancer 86:1652–1657

    CAS  Google Scholar 

  12. Alberto R (2007) J Organomet Chem 692:1179–1186

    CAS  Google Scholar 

  13. Wester DW, Coveney JR, Nosco DL, Robbins MS, Dean RT (1991) J Med Chem 34:3284–3290

    CAS  Google Scholar 

  14. Abrams MJ, Davison A, Jones AG, Costello CE, Pang H (1983) Inorg Chem 22:2798–2800

    CAS  Google Scholar 

  15. Alberto R, Schibli R, Egli A, Schubiger AP, Abram U, Kaden TA (1998) J Am Chem Soc 120:7987–7988

    CAS  Google Scholar 

  16. Schibli R, Marti N, Maurer P, Spingler B, Lehaire ML, Gramlich V, Barnes CL (2005) Inorg Chem 44:683–690

    CAS  Google Scholar 

  17. Pietzsch HJ, Tisato F, Refosco F, Leibnitz P, Drews A, Seifert S, Spies H (2001) Inorg Chem 40:59–64

    CAS  Google Scholar 

  18. Pietzsch HJ, Gupta A, Syhre R, Leibnitz P, Spies H (2001) Bioconjug Chem 12:538–544

    CAS  Google Scholar 

  19. Metzler-Nolte (2010) Biomedical applications of organometal-peptide conjugates. In: Topics in organometallic chemistry. Springer, Heidelberg

    Google Scholar 

  20. Rattat D, Schubiger PA, Berke HG, Schmalle H, Alberto R (2001) Cancer Biother Radiopharm 16:339–343

    CAS  Google Scholar 

  21. Rattat D, Verbruggen A, Schmalle H, Berke H, Alberto R (2004) Tetrahedron Lett 45:4089–4092

    CAS  Google Scholar 

  22. Marti N, Spingler B, Breher F, Schibli R (2005) Inorg Chem 44:6082–6091

    CAS  Google Scholar 

  23. Seifert S, Kunstler JU, Schiller E, Pietzsch HJ, Pawelke B, Bergmann R, Spies H (2004) Bioconjug Chem 15:856–863

    CAS  Google Scholar 

  24. Walther M, Jung CM, Bergmann R, Pietzsch J, Rode K, Fahmy K, Mirtschink P, Stehr S, Heintz A, Wunderlich G, Kraus W, Pietzsch HJ, Kropp J, Deussen A, Spies H (2007) Bioconjug Chem 18:216–230

    CAS  Google Scholar 

  25. Mirtschink P, Stehr SN, Pietzsch HJ, Bergmann R, Pietzsch J, Wunderlich G, Heintz AC, Kropp J, Spies H, Kraus W, Deussen A, Walther M (2008) Bioconjug Chem 19:97–108

    CAS  Google Scholar 

  26. Kunstler JU, Veerendra B, Figueroa SD, Sieckman GL, Rold TL, Hoffman TJ, Smith CJ, Pietzsch HJ (2007) Bioconjug Chem 18:1651–1661

    CAS  Google Scholar 

  27. Liu S (2007) Dalton Trans 1183–1193

    Google Scholar 

  28. Jain D (1999) Semin Nucl Med 29:221–236

    CAS  Google Scholar 

  29. Santos I, Paulo A, Correia JDG (2005) Contrast agents III: radiopharmaceuticals – from diagnostics to therapeutics. Top Curr Chem 252:45–84

    CAS  Google Scholar 

  30. Maria L, Cunha S, Videira M, Gano L, Paulo A, Santos IC, Santos I (2007) Dalton Trans 3010–3019

    Google Scholar 

  31. Maria L, Fernandes C, Garcia R, Gano L, Paulo A, Santos IC, Santos I (2009) Dalton Trans 603–606

    Google Scholar 

  32. Hao GY, Zang JY, Zhu L, Guo YZ, Liu BL (2004) J Labelled Comp Radiopharm 47:513–521

    CAS  Google Scholar 

  33. He Z, Hsieh W-Y, Kim Y-S, Liu S (2006) Nucl Med Biol 33:1045–1053

    CAS  Google Scholar 

  34. He HY, Lipowska M, Christoforou AM, Marzilli LG, Taylor AT (2007) Nucl Med Biol 34:709–716

    CAS  Google Scholar 

  35. He H, Lipowska M, Xu X, Taylor AT, Marzilli LG (2007) Inorg Chem 46:3385–3394

    CAS  Google Scholar 

  36. Kung M-P, Stevenson DA, Plössl K, Meegalla SK, Beckwith A, Essman WD, Mu M, Lucki I, Kung HF (1997) Eur J Nucl Med 24:372–380

    CAS  Google Scholar 

  37. Kung HF, Kung MP, Wey SP, Lin KJ, Yen TC (2007) Nucl Med Biol 34:787–789

    CAS  Google Scholar 

  38. Lipowska M, Marzilli LG, Taylor AT (2009) J Nucl Med 50:454–460

    CAS  Google Scholar 

  39. Alberto R (2009) Eur J Inorg Chem 21–31

    Google Scholar 

  40. Lipowska M, He HY, Malveaux E, Xu XL, Marzilli LG, Taylor A (2006) J Nucl Med 47:1032–1040

    CAS  Google Scholar 

  41. Wang WW, Hor TSA, Yan YK (2006) Inorg Chim Acta 359:3754–3762

    CAS  Google Scholar 

  42. Allali MC, Cousinié S, Gressier M, Tessier C, Beauchamp AL, Coulais Y, Dartiguenave M, Benoist E (2006) Inorg Chim Acta 359:2128–2134

    CAS  Google Scholar 

  43. Bolzati C, Boschi A, Uccelli L, Tisato F, Refosco F, Cagnolini A, Duatti A, Prakash S, Bandoli G, Vittadini A (2002) J Am Chem Soc 124:11468–11479

    CAS  Google Scholar 

  44. Bolzati C, Boschi A, Duatti A, Prakash S, Uccelli L (2000) J Am Chem Soc 122:4510–4511

    CAS  Google Scholar 

  45. Bolzati C, Refosco F, Cagnolini A, Tisato F, Boschi A, Duatti A, Uccelli L, Dolmella A, Marotta E, Tubaro M (2004) Eur J Inorg Chem 1902–1913

    Google Scholar 

  46. Boschi A, Uccelli L, Duatti A, Bolzati C, Refosco F, Tisato F, Romagnoli R, Baraldi PG, Varani K, Borea PA (2003) Bioconjug Chem 14:1279–1288

    CAS  Google Scholar 

  47. Knapp FF, Kropp J (1995) Eur J Nucl Med 22:361–381

    CAS  Google Scholar 

  48. Schiller E, Seifert S, Tisato F, Refosco F, Kraus W, Spies H, Pietzsch HJ (2005) Bioconjug Chem 16:634–643

    CAS  Google Scholar 

  49. Wald J, Alberto R, Ortner K, Candreia L (2001) Angew Chem Int Ed 40:3062–3066

    CAS  Google Scholar 

  50. Bernard J, Ortner K, Spingler B, Pietzsch HJ, Alberto R (2003) Inorg Chem 42:1014–1022

    CAS  Google Scholar 

  51. Wenzel M (1992) J Labelled Comp Radiopharm 31:641–650

    CAS  Google Scholar 

  52. Uehara T, Uemura T, Hirabayashi S, Adachi S, Odaka K, Akizawa H, Magata Y, Irie T, Arano Y (2007) J Med Chem 50:543–549

    CAS  Google Scholar 

  53. Lee BC, Kim DH, Lee I, Choe YS, Chi DY, Lee K-H, Choi Y, Kim B-T (2008) J Med Chem 51:3630–3634

    CAS  Google Scholar 

  54. Lee BC, Choe YS, Chi DY, Paik JY, Lee KH, Choi Y, Kim BT (2004) Bioconjug Chem 15:121–127

    CAS  Google Scholar 

  55. Trump DP, Mathias CJ, Yang ZF, Low PSW, Marmion M, Green MA (2002) Nucl Med Biol 29:569–573

    CAS  Google Scholar 

  56. Muller C, Dumas C, Hoffmann U, Schubiger PA, Schibli R (2004) J Organomet Chem 689:4712–4721

    Google Scholar 

  57. Muller C, Hohn A, Schubiger PA, Schibli R (2006) Eur J Nucl Med Mol Imaging 33:1007–1016

    Google Scholar 

  58. Muller C, Bruhlmeier M, Schubiger PA, Schibli R (2006) J Nucl Med 47:2057–2064

    CAS  Google Scholar 

  59. Viola-Villegas N, Rabideau AE, Cesnavicious J, Zubieta J, Doyle RP (2008) ChemMedChem 3:1387–1394

    CAS  Google Scholar 

  60. Adam MJ, Wilbur DS (2005) Chem Soc Rev 34:153–163

    CAS  Google Scholar 

  61. Bowen ML, Orvig C (2008) Chem Commun 5077–5091

    Google Scholar 

  62. Zhang M, Zhang ZH, Blessington D, Li H, Busch TM, Madrak V, Miles J, Chance B, Glickson JD, Zheng G (2003) Bioconjug Chem 14:709–714

    CAS  Google Scholar 

  63. Speizer L, Haugland R, Kutchai H (1985) Biochim Biophys Acta 815:75–84

    CAS  Google Scholar 

  64. Petrig J, Schibli R, Dumas C, Alberto R, Schubiger PA (2001) Chem Eur J 7:1868–1873

    CAS  Google Scholar 

  65. Dumas C, Petrig J, Frei L, Spingler B, Schibli R (2005) Bioconjug Chem 16:421–428

    CAS  Google Scholar 

  66. Schibli R, Dumas C, Petrig J, Spadola L, Scapozza L, Garcia-Garayoa E, Schubiger PA (2005) Bioconjug Chem 16:105–112

    CAS  Google Scholar 

  67. Halmos T, Santarromana M, Antonakis K, Scherman D (1996) Eur J Pharmacol 318:477–484

    CAS  Google Scholar 

  68. Bayly SR, Fisher CL, Storr T, Adam MJ, Orvig C (2004) Bioconjug Chem 15:923–926

    CAS  Google Scholar 

  69. Storr T, Fisher CL, Mikata Y, Yano S, Adam MJ, Orvig C (2005) Dalton Trans 654–655

    Google Scholar 

  70. Storr T, Obata M, Fisher CL, Bayly SR, Green DE, Brudzinska I, Mikata Y, Patrick BO, Adam MJ, Yano S, Orvig C (2005) Chem Eur J 11:195–203

    Google Scholar 

  71. Storr T, Sugai Y, Barta CA, Mikata Y, Adam MJ, Yano S, Orvig C (2005) Inorg Chem 44:2698–2705

    CAS  Google Scholar 

  72. Ferreira CL, Bayly SR, Green DE, Storr T, Barta CA, Steele J, Adam MJ, Orvig C (2006) Bioconjug Chem 17:1321–1329

    CAS  Google Scholar 

  73. Sogbein OO, Green AEC, Schaffer P, Chankalal R, Lee E, Healy BD, Morel P, Valliant JF (2005) Inorg Chem 44:9574–9584

    CAS  Google Scholar 

  74. Green AEC, Harrington LE, Valliant JF (2008) Can J Chem 86:1063–1069

    CAS  Google Scholar 

  75. Masi S, Top S, Boubekeur L, Jaouen G, Mundwiler S, Spingler B, Alberto R (2004) Eur J Inorg Chem 10:2013–2017

    Google Scholar 

  76. Ferreira CL, Ewart CB, Bayly SR, Patrick BO, Steele J, Adam MJ, Orvig C (2006) Inorg Chem 45:6979–6987

    CAS  Google Scholar 

  77. Hinrichs M, Hofbauer FR, Klufers P (2006) Chem Eur J 12:4675–4683

    CAS  Google Scholar 

  78. Gottschaldt M, Koth D, Muller D, Klette I, Rau S, Gorls H, Schafer B, Baum RP, Yano S (2007) Chem Eur J 13:10273–10280

    CAS  Google Scholar 

  79. Schibli R, Netter M, Scapozza L, Birringer M, Schelling P, Dumas C, Schoch J, Schubiger PA (2003) J Organomet Chem 668:67–74

    CAS  Google Scholar 

  80. Desbouis D, Schubiger PA, Schibli R (2007) J Organomet Chem 692:1340–1347

    CAS  Google Scholar 

  81. Stichelberger M, Desbouis D, Spiwok V, Scapozza L, Schubiger PA, Schibli R (2007) J Organomet Chem 692:1255–1264

    CAS  Google Scholar 

  82. Wei LH, Babich J, Eckelman WC, Zubieta J (2005) Inorg Chem 44:2198–2209

    CAS  Google Scholar 

  83. Desbouis D, Struthers H, Spiwok V, Kuster T, Schibli R (2008) J Med Chem 51:6689–6698

    CAS  Google Scholar 

  84. Yanagida O, Kanai Y, Chairoungdua A, Kim DK, Segawa H, Nii T, Cha SH, Matsuo H, Fukushima J, Fukasawa Y, Tani Y, Taketani Y, Uchino H, Kim JY, Inatomi J, Okayasu I, Miyamoto K, Takeda E, Goya T, Endou H (2001) Biochim Biophys Acta 1514:291–302

    CAS  Google Scholar 

  85. Kanai Y, Segawa H, Miyamoto K, Uchino H, Takeda E, Endou H (1998) J Biol Chem 273:23629–23632

    CAS  Google Scholar 

  86. Shikano N, Kanai Y, Kawai K, Ishikawa N, Endou H (2003) Nucl Med Biol 30:31–37

    CAS  Google Scholar 

  87. Liu Y, Pak J-K, Schmutz P, Bauwens M, Mertens J, Knight H, Alberto R (2006) J Am Chem Soc 128:15996–15997

    CAS  Google Scholar 

  88. Okuda K (1999) J Gastroenterol Hepatol 14:301–308

    CAS  Google Scholar 

  89. Collins DA, Hogenkamp HPC, Gebhard MW (1999) Mayo Clin Proc 74:687–691

    CAS  Google Scholar 

  90. Collins DA, Hogenkamp HPC, O’Connor MK, Naylor S, Benson LM, Hardyman TJ, Thorson LM (2000) Mayo Clin Proc 75:568–580

    CAS  Google Scholar 

  91. Kunze S (2004) Novel 99mTc labelled derivatives of vitamin B12 for cancer diagnosis: a colourful chemistry, Thesis, University of Zürich

    Google Scholar 

  92. Mundwiler S, Waibel R, Spingler B, Kunze S, Alberto R (2005) Nucl Med Biol 32:473–484

    CAS  Google Scholar 

  93. van Staveren DR, Mundwiler S, Hoffmanns U, Pak JK, Spingler B, Metzler-Nolte N, Alberto R (2004) Org Biomol Chem 2:2593–2603

    Google Scholar 

  94. van Staveren DR, Waibel R, Mundwiler S, Schubiger PA, Alberto R (2004) J Organomet Chem 689:4803–4810

    Google Scholar 

  95. Spingler B, Mundwiler S, Ruiz-Sanchez P, van Staveren DR, Alberto R (2007) Eur J Inorg Chem 18:2641–2647

    Google Scholar 

  96. Waibel R, Treichler H, Schaefer NG, van Staveren DR, Mundwiler S, Kunze S, Kuenzi M, Alberto R, Nuesch J, Knuth A, Moch H, Schibli R, Schubiger PA (2008) Cancer Res 68:2904–2911

    CAS  Google Scholar 

  97. Kunze S, Zobi F, Kurz P, Spingler B, Alberto R (2004) Angew Chem Int Ed 43:5025–5029

    CAS  Google Scholar 

  98. Ruiz-Sanchez P, Mundwiler S, Spingler B, Buan NR, Escalante-Semerena JC, Alberto R (2008) J Biol Inorg Chem 13:335–347

    CAS  Google Scholar 

  99. Blower P (2006) Dalton Trans 1705–1711

    Google Scholar 

  100. Santra S, Yang H, Dutta D, Stanley JT, Holloway PH, Tan WH, Moudgil BM, Mericle RA (2004) Chem Commun 2810–2811

    Google Scholar 

  101. Haefliger P, Agorastos N, Spingler B, Georgiev O, Viola G, Alberto R (2005) Chembiochem 6:414–421

    CAS  Google Scholar 

  102. Mundwiler S, Kuendig M, Ortner K, Alberto R (2004) Dalton Trans 1320–1328

    Google Scholar 

  103. Agorastos N, Borsig L, Renard A, Antoni P, Viola G, Spingler B, Kurz P, Alberto R (2007) Chem Eur J 13:3842–3852

    CAS  Google Scholar 

  104. Vitor RF, Correia I, Videira M, Marques F, Paulo A, Pessoa JC, Viola G, Martins GG, Santos I (2008) Chembiochem 9:131–142

    CAS  Google Scholar 

  105. Sanche L (2005) Eur Phys J D 35:367–390

    CAS  Google Scholar 

  106. Watanabe N, Sawai H, Ogihara-Umeda I, Tanada S, Kim EE, Yonekura Y, Sasaki Y (2006) J Nucl Med 47:1670–1677

    CAS  Google Scholar 

  107. Behr TM, Behe M, Lohr M, Sgouros G, Angerstein C, Wehrmann E, Nebendahl K, Becker W (2000) Eur J Nucl Med 27:753–765

    CAS  Google Scholar 

  108. Bartholoma M, Valliant J, Maresca KP, Babich J, Zubieta J (2009) Chem Commun 493–512

    Google Scholar 

  109. Stephenson KA, Zubieta J, Banerjee SR, Levadala MK, Taggart L, Ryan L, McFarlane N, Boreham DR, Maresca KP, Babich JW, Valliant JF (2004) Bioconjug Chem 15:128–136

    CAS  Google Scholar 

  110. Stephenson KA, Banerjee SR, Besanger T, Sogbein OO, Levadala MK, McFarlane N, Lemon JA, Boreham DR, Maresca KP, Brennan JD, Babich JW, Zubieta J, Valliant JF (2004) J Am Chem Soc 126:8598–8599

    CAS  Google Scholar 

  111. Wei LH, Babich JW, Ouellette W, Zubieta J (2006) Inorg Chem 45:3057–3066

    CAS  Google Scholar 

  112. Schaffer PJAG, Lemon JA, Reid LC, Pacey LKK, Farncombe TH, Boreham DR, Zubieta J, Babich JW, Doering LC, Valliant JF (2008) Nucl Med Biol 35:159–169

    CAS  Google Scholar 

  113. James S, Maresca KP, Allis DG, Valliant JF, Eckelman W, Babich JW, Zubieta J (2006) Bioconjug Chem 17:579–589

    CAS  Google Scholar 

  114. James S, Maresca KP, Babich JW, Valliant JF, Doering L, Zubieta J (2006) Bioconjug Chem 17:590–596

    CAS  Google Scholar 

  115. Alberto R (2006) In: Jaouen G (ed) Bioorganometallics. Wiley-VCH, Weinheim, pp 97–124

    Google Scholar 

  116. Alberto R (2005) Contrast agents III: radiopharmaceuticals – from diagnostics to therapeutics. Top Curr Chem 252:1–44

    CAS  Google Scholar 

  117. Alberto R, Abram U (2005) In: Vertes A, Nagy S, Klencsar Z (eds) Nuclear chemistry, vol 4, Radiochemistry and radiopharmaceutical chemistry in life science. Kluwer, Dordrecht, pp 211–256

    Google Scholar 

  118. Top S, Vessieres A, Pigeon P, Rager MN, Huche M, Salomon E, Cabestaing C, Vaissermann J, Jaouen G (2004) Chembiochem 5:1104–1113

    CAS  Google Scholar 

  119. Top S, Vessieres A, Cabestaing C, Laios I, Leclercq G, Provot C, Jaouen G (2001) J Organomet Chem 637–639:500–506

    Google Scholar 

  120. Jaouen G, Top S, Vessières A, Pigeon P, Leclercq G, Laios I (2001) Chem Commun 383–384

    Google Scholar 

  121. Wenzel M, Klinge C (1994) J Labelled Comp Radiopharm XXXIV 981–987

    Google Scholar 

  122. Cesati IRR, Katzenellenbogen JA (2001) J Am Chem Soc 17:4093–4094

    Google Scholar 

  123. Cesati RR, Tamagnan G, Baldwin RM, Zoghbi SS, Innis RB, Katzenellenbogen JA (1999) J Labelled Comp Radiopharm 42:S150–S152

    Google Scholar 

  124. Liu Y, Spingler B, Schmultz P, Alberto R (2008) J Am Chem Soc 130:1554–1555

    CAS  Google Scholar 

  125. N’Dongo HWP, Liu Y, Can D, Schmutz P, Spingler B, Alberto R (2009) J Organomet Chem 694:981–987

    Google Scholar 

  126. Valliant JF, Sogbein OO, Morel P, Schaffer P, Guenther KJ, Bain AD (2002) Inorg Chem 41:2731–2737

    CAS  Google Scholar 

  127. Sogbein OO, Merdy P, Morel P, Valliant JF (2004) Inorg Chem 43:3032–3034

    CAS  Google Scholar 

  128. Sogbein OO, Green AEC, Valliant JF (2005) Inorg Chem 44:9585–9591

    CAS  Google Scholar 

  129. Green AEC, Causey PW, Louie AS, Armstrong AF, Harrington LE, Valliant JF (2006) Inorg Chem 45:5727–5729

    CAS  Google Scholar 

  130. Causey PW, Besanger TR, Schaffer P, Valliant JF (2008) J Med Chem 51:2833–2844

    CAS  Google Scholar 

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  1. Institute of Inorganic Chemistry, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland

    Roger Alberto

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  1. Roger Alberto
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Correspondence to Roger Alberto .

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  1. Chimie de Paris (ENSCP), Ecole Nationale Superieure de, rue Pierre et Marie Curie 11, Paris CX 05, 75231, France

    Gérard Jaouen

  2. LS für Anorganische Chemie I -, Bioanorganische Chemie, Universität Bochum, Universitätsstr. 150, Bochum, 44801, Germany

    Nils Metzler-Nolte

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Alberto, R. (2010). Organometallic Radiopharmaceuticals. In: Jaouen, G., Metzler-Nolte, N. (eds) Medicinal Organometallic Chemistry. Topics in Organometallic Chemistry, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13185-1_9

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