Abstract
A 3-dimensional mesofluidic biological monitoring module has been successfully designed and fabricated using a low-temperature co-fired ceramic (LTCC) technology. This mesofluidic device consists of a network of micro-channels, a spherical mixing cavity and measuring ports. A selection of appropriate commercially available ceramic tapes has been chosen with regard to their biocompatibility performance. Specific processing procedures required for the realization of such a complex structure are demonstrated. Three dimensional numerical flow simulations have been conducted to characterize the concentration profiles of liquids at a specific measuring port and verified by experiment.
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Anderson, J.R., Chiu, D.T., Jackman, J., Cherniavskaya, O., McDonald, J.C., Wu, H., Whitesides, S.H., Whitesides, G.M.: Fabrication of topologically complex three-dimensional microfluidic systems in PDMS by rapid prototyping. Anal. Chem. 72, 3158–3164 (2000)
Kathuria, Y.P.: An overview of 3D structuring in microdomain. J. Indian Inst. Sci. 81, 659–664 (2001)
Yu, H., Balogun, O., Li, B., Murray, T.W., Zhang, X.: Fabrication of three dimensional microstructures based on single-layered SU-8 for lab- on-chip applications. Sensors Actuat. A Phys. 127, 228–234 (2006)
Knitter, R., Bauer, W., Göhring, D.: Microfabrication of ceramics by rapid prototyping process chains. J. Mechan. Eng. Sci. 217, 41–51 (2003)
Golonka, L.J., Zawada, T., Radojewski, J., Roguszczak, H., Stefanow, M.: LTCC Microfluidic System. Int. J. Appl. Ceram. Technol. 3, 150–156 (2006)
Kügler, P., Gaubitzer, E., Müller, S.: Parameter identification for chemical reaction systems using the adjoint technique and sparsity enforcing stabilization - a case study for the Chloride Iodide reaction. J. Phys. Chem. A 113, 2775–2785 (2009)
Gire, V., Wynfford-Thomas, D.W.: Reinitiation of DNA Synthesis and Cell Division in Senescent Human Fibroblasts by Microinjection of Anti-p53 Antibodies. Mol. Cell. Biol. 18, 1611–1621 (1998)
Zamai, L., Canonico, B., Luchetti, F., Ferri, P., Melloni, E., Guidotti, L., Cappellini, A., Cutroneo, G., Vitale, M., Papa, S.: Supravial Exposure to Propidium Iodide Indentifies Apoptosies on Adherent Cells. Cytometry 44, 57–64 (2001)
Smetana, W., Balluch, B., Stangl, G., Lüftl, S., Seidler, S.: Processing procedures for the realization of fine structured channel arrays and bridging elements by LTCC-technology. Microelect. Rel. (in print)
Birol, H., Maeder, T., Jacq, C., Straessler, S., Ryser, P.: Fabrication of Low-Temperature Co-fired Ceramics micro-fluidic devices using sacrificial carbon layers. Int. J. Appl. Ceram. Technol. 2, 364–373 (2005)
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Smetana, W. et al. (2010). A Ceramic Microfluidic Device for Monitoring Complex Biochemical Reactive Systems. In: Fred, A., Filipe, J., Gamboa, H. (eds) Biomedical Engineering Systems and Technologies. BIOSTEC 2009. Communications in Computer and Information Science, vol 52. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11721-3_8
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DOI: https://doi.org/10.1007/978-3-642-11721-3_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-11720-6
Online ISBN: 978-3-642-11721-3
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