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The Role of KIR in Disease

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Natural Killer Cells

Abstract

Following the cloning of the killer cell immunoglobulin-like (KIR) genes in 1995 (Colonna M, Samaridis J. Science 268(5209):405–408, 1995) their population diversity has become increasingly apparent. This has spawned a plethora of disease association studies. As the KIR genes need to be considered in combination with their MHC class I ligands, this has added complexity to the analysis of these studies. KIR, and KIR:MHC class I gene combinations have been associated with viral infections, autoimmunity, transplantation and pregnancy-associated disorders. Simple rules, with which to interpret these datasets, are often difficult to find and, as our understanding of the interaction between KIR and MHC class I increases, the analysis of these datasets will become even more complex. This review attempts to summarize our current knowledge whilst indicating areas of potential further complexity.

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Acknowledgments

I would like to acknowledge the assistance of Dr Lucia Possami in the construction of the figure and valuable comments on the manuscript.

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  1. Department of Hepatology, Division of Medicine, Imperial College, 10th floor QEQM Building, St Mary’s Hospital Campus, South Wharf Road, London W2 1PG, London, UK

    Salim I Khakoo

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Correspondence to Salim I Khakoo .

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  1. Lab. Immuno-Allergologie, Centre de Recherche Public, Val Fleuri 84, Luxembourg, 1526, Luxembourg

    Jacques Zimmer

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Khakoo, S.I. (2010). The Role of KIR in Disease. In: Zimmer, J. (eds) Natural Killer Cells. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02309-5_15

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