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European Conference on Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics

EvoBIO 2009: Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics pp 80–91Cite as

Conquering the Needle-in-a-Haystack: How Correlated Input Variables Beneficially Alter the Fitness Landscape for Neural Networks

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Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 5483))

Abstract

Evolutionary algorithms such as genetic programming and grammatical evolution have been used for simultaneously optimizing network architecture, variable selection, and weights for artificial neural networks. Using an evolutionary algorithm to perform variable selection while searching for non-linear interactions is akin to searching for a needle in a haystack. There is, however, a considerable amount of correlation among variables in biological datasets, such as in microarray or genetic studies. Using the XOR problem, we show that correlation between non-functional and functional variables alters the variable selection fitness landscape by broadening the fitness peak over a wider range of potential input variables. Furthermore, when sub-optimal weights are used, local optima in the variable selection fitness landscape appear centered on each of the two functional variables. These attributes of the fitness landscape may supply building blocks for evolutionary search procedures, and may provide a rationale for conducting a local search for variable selection.

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Author information

Authors and Affiliations

  1. Center for Human Genetics Research, Department of Molecular Physiology & Biophysics, Vanderbilt University, Nashville, TN, USA

    Stephen D. Turner, Marylyn D. Ritchie & William S. Bush

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  1. Stephen D. Turner
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  2. Marylyn D. Ritchie
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  3. William S. Bush
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Editor information

Editors and Affiliations

  1. Italian National Research Council (CNR), Institute for High-Performance Computing and Networking (ICAR), Via P. Bucci 41C, 87036, Rende (CS), Italy

    Clara Pizzuti

  2. Center for Human Genetics Research Department of Molecular Physiology & Biophysics, Vanderbilt University, 519 Light Hall, TN 37232, Nashville, USA

    Marylyn D. Ritchie

  3. Department of Animal Production Epidemiology and Ecology, University of Torino, Via Leonardo da Vinci 44, 10095, Grugliasco, Italy

    Mario Giacobini

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© 2009 Springer-Verlag Berlin Heidelberg

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Turner, S.D., Ritchie, M.D., Bush, W.S. (2009). Conquering the Needle-in-a-Haystack: How Correlated Input Variables Beneficially Alter the Fitness Landscape for Neural Networks. In: Pizzuti, C., Ritchie, M.D., Giacobini, M. (eds) Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics. EvoBIO 2009. Lecture Notes in Computer Science, vol 5483. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-01184-9_8

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  • DOI: https://doi.org/10.1007/978-3-642-01184-9_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-01183-2

  • Online ISBN: 978-3-642-01184-9

  • eBook Packages: Computer ScienceComputer Science (R0)

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