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Generation and Characterization of Candidate Vaccine Viruses for Prepandemic Influenza Vaccines

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Book cover Vaccines for Pandemic Influenza

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 333))

Abstract

Vaccination will be a critical public health intervention to mitigate the next influenza pandemic. Its effectiveness will depend on preparedness at multiple levels, from the laboratory bench to the population. Here we describe a global approach to ensure that appropriate candidate vaccine viruses are produced, evaluated, and made available to vaccine manufacturers in a timely fashion. This is an integrated activity involving global virologic and epidemiologic surveillance, genetic and antigenic characterization of influenza viruses, pandemic risk assessments, selection of appropriate virus strains for vaccines, production of reassortant viruses by reverse genetics, and finally, analysis of their safety and growth characteristics prior to distribution. These procedures must comply with national and international regulations governing vaccine and environmental safety.

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Acknowledgments

Derivation of prepandemic candidate vaccine viruses was supported in part by grants from the National Vaccine Program Office, Department of Health and Human Services. We thank all the members of the WHO Global Influenza Surveillance Network for continued support. We thank Elizabeth Mumford and Wenqing Zhang in the WHO Global Influenza Program for helpful discussions. We thank Todd Davis for phylogenetic analyses and James Stevens for very valuable suggestions. We thank our colleagues in the Influenza Division; in particular, the many contributions of the Virus Surveillance and Diagnosis Branch and the Molecular Virology and Vaccines Branch are greatly appreciated.

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  1. Influenza Division, National Center for Immunization and Respiratory Diseases, Coordinating Centers for Infectious Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road—Mail Stop G-16, Atlanta, GA, 30333, USA

    Eduardo O’Neill & Ruben O. Donis

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  1. Eduardo O’Neill
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  2. Ruben O. Donis
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Correspondence to Ruben O. Donis .

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  1. School of Medicine, Emory University, Atlanta, 30322, U.S.A.

    Richard W. Compans

  2. School of Medicine, Emory University, Clifton Road 1510, Atlanta, 30322, U.S.A.

    Walter A. Orenstein

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O’Neill, E., Donis, R.O. (2009). Generation and Characterization of Candidate Vaccine Viruses for Prepandemic Influenza Vaccines. In: Compans, R., Orenstein, W. (eds) Vaccines for Pandemic Influenza. Current Topics in Microbiology and Immunology, vol 333. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-92165-3_4

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