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Aquaporins pp 309–325Cite as

Aquaglyceroporins and Metalloid Transport: Implications in Human Diseases

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 190))

Aquaglyceroporin (AQP) channels facilitate the diffusion of a wide range of neutral solutes, including water, glycerol, and other small uncharged solutes. More recently, AQPs have been shown to allow the passage of trivalent arsenic and antimony compounds. Arsenic and antimony are metalloid elements. At physiological pH, the trivalent metalloids behave as molecular mimics of glycerol, and are conducted through AQP channels. Arsenicals and antimonials are extremely toxic to cells. Despite their toxicity, both metalloids are used as chemotherapeutic agents for the treatment of cancer and protozoan parasitic diseases. The metalloid home-ostasis property of AQPs can be a mixed blessing. In some cases, AQPs form part of the detoxification pathway, and extrude metalloids from cells. In other instances, AQPs allow the transport of metalloids into cells, thereby conferring sensitivity. Understanding the factors that modulate AQP expression will aid in a better understanding of metalloid toxicity and also provide newer approaches to metalloid based chemotherapy.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, Detroit, MI, 48201, USA

    Hiranmoy Bhattacharjee

  2. Rosen Department of Biochemistry and Molecular Biology, Wayne State University, School of Medicine, Detroit, MI, 48201, USA

    Barry P. Rosen

  3. Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, 4351 Scott Hall, 540 East Canfield Avenue, Detroit, MI, 48201, USA

    Rita Mukhopadhyay

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  1. Hiranmoy Bhattacharjee
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  2. Barry P. Rosen
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  3. Rita Mukhopadhyay
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Correspondence to Rita Mukhopadhyay .

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  1. Pharmazeutisches Inst., Universität Kiel, Gutenbergstr. 76, Kiel, 24118, Germany

    Eric Beitz

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Bhattacharjee, H., Rosen, B.P., Mukhopadhyay, R. (2009). Aquaglyceroporins and Metalloid Transport: Implications in Human Diseases. In: Beitz, E. (eds) Aquaporins. Handbook of Experimental Pharmacology, vol 190. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-79885-9_16

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