Abstract
The biclustering techniques have the purpose of finding subsets of genes that show similar activity patterns under a subset of conditions. In this paper we characterize a specific type of pattern, that we have called α–pattern, and present an approach that consists in a new biclustering algorithm specifically designed to find α–patterns, in which the gene expression values evolve across the experimental conditions showing a similar behavior inside a band that ranges from 0 up to a pre–defined threshold called α. The α value guarantees the co–expression among genes. We have tested our method on the Yeast dataset and compared the results to the biclustering algorithms of Cheng & Church (2000) and Aguilar & Divina (2005). Results show that the algorithm finds interesting biclusters, grouping genes with similar behaviors and maintaining a very low mean squared residue.
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Rodríguez-Baena, D.S., Diaz-Diaz, N., Aguilar-Ruiz, J.S., Nepomuceno-Chamorro, I. (2007). Discovering α–Patterns from Gene Expression Data. In: Yin, H., Tino, P., Corchado, E., Byrne, W., Yao, X. (eds) Intelligent Data Engineering and Automated Learning - IDEAL 2007. IDEAL 2007. Lecture Notes in Computer Science, vol 4881. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-77226-2_83
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DOI: https://doi.org/10.1007/978-3-540-77226-2_83
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-77225-5
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